Features of some vasoactive hormones and vascular factors in women with metabolic syndrome and their influence on the development of obstetric complications
Objective. To investigate the characteristics of effector hormones of peripheral endocrine glands (adrenaline, noradrenaline, cortisol, angiotensin II, and endothelin-1) in women with metabolic syndrome and their influence on the development of obstetric pathology.Palieva N.V., Botasheva T.L., Linde V.A., Avrutskaya V.V., Zheleznyakova E.V.
Subjects and methods. The prospective case-control study used an enzyme immunoassay technique to determine the serum levels of adrenaline, noradrenaline, cortisol, angiotensin II, and endothelin-1 in 150 patients with metabolic syndrome and in 143 women with normal metabolism over time during pregnancy (1–3 trimesters). For data analysis, the investigators used descriptive statistics procedures that were employed to estimate the median values and interquartile ranges (25%, 75%). The significance level was set to be equal to 0.05.
Results and discussion. Just in the first trimester, the patients with preeclampsia in the presence of metabolic syndrome showed a more pronounced increase in the level of endothelin-1 (p = 0.0327), adrenaline (p = 0.0211), and cortisol (p = 0.0018) than the women with fetal growth retardation, which indicates an increased likelihood for vasoconstrictor effects and the development of endothelial dysfunction in case of preeclampsia.
Conclusion. The findings may assert that just in early pregnancy, the women with metabolic syndrome have a considerable increase in the levels of vasoactive hormones, which is exaggerated by endothelial dysfunction, in the presence of which the vasospastic processes are predominant mainly in women with preeclampsia.
Keywords
physiological and complicated pregnancy
metabolic syndrome
fetal growth retardation
preeclampsia
vasoactive hormones
vascular factors
Supplementary Materials
- Table 1 –Content of effect or hormones of peripheral endocrine glands in blood serum of pregnant women with the metabolic syndrome and normal metabolism
- Table 2 – Content of effect or hormones of peripheral endocrine glands in blood serum of women with the metabolic syndrome and normal metabolism depending on the clinical course of pregnancy
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Received 20.06.2016
Accepted 02.09.2016
About the Authors
Natalia Viktorovna Palieva, Candidate of Medical Sciences, Academic Secretary of Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia.344012, Russia, Rostov-on-Don, Mechnikova str. 43. Tel.: +79282964696. E-mail: nat-palieva@yandex.ru
Tatiana Leonidovna Botasheva, Doctor of Medicine, Professor, Head of the Female Physiology Laboratory, Chief Researcher of the Obstetrics and Gynecology Department, Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia.
344012, Russia, Rostov-on-Don, Mechnikova str. 43. Tel.: +78632009259. E-mail: t_botasheva@mail.ru
Viktor Anatolievich Linde, Doctor of Medicine, Professor, Director of Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia.
344012, Russia, Rostov-on-Don, Mechnikova str. 43. Tel.: +78632903323. E-mail: vik-linde@yandex.ru
Valeria Viktorovna Avrutskaya, Doctor of Medicine, Chief Researcher of the Obstetrics and Gynecology Department, Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia. 344012, Russia, Rostov-on-Don, Mechnikova str. 43. Tel.: +78632275205. E-mail: V.Avrutskaya@rniiap.ru
Elena Vasilievna Zheleznyakova, Candidate of Medical Sciences, Researcher of the Female Physiology Laboratory of the Obstetrics and Gynecology Department,
Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia.
344012, Russia, Rostov-on-Don, Mechnikova str. 43. Tel.: +78632009259. E-mail: elena.gel.1961@yandex.ru
For citations: Palieva N.V., Botasheva T.L., Linde V.A., Avrutskaya V.V., Zheleznyakova E.V. Features of some vasoactive hormones and vascular factors in women with metabolic syndrome and their influence on the development of obstetric complications.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (6): 48-54. (in Russian)
http://dx.doi.org/10.18565/aig.2017.6.48-54
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