The features of clinical course and complexities in the diagnosis of a case of epithelioid trophoblastic disease

Chernyshova A.L., Kolomiets L.A., Kishkina A.Yu., Ochirov M.O., Glushchenko S.A., Perelmuter V.M.

Research Institute of Oncology, Tomsk National Research Medical Center, Tomsk, Russia
Background. Epithelioid trophoblastic tumor was first described by morphologists in 1995; the world literature reports only about 90 cases of this tumor, which confirms its extreme rarity. This type of tumor is characterized by high malignancy and fairly rapid distant metastasis. At the same time, the current chemotherapy regimens, even those for distant metastases, show a good sufficient efficiency.
Clinical case report. The paper analyzes the features of clinical course, diagnostic difficulties, and the observation in epithelioid tumor. It presents difficulties in the interpretation of clinical data and in the differential diagnosis of morphological features in this type of tumor. The authors show the expediency and high informative value of immunohistochemical examination of a tissue specimen.
Conclusion. This category of patients should be examined and treated in specialized clinics that have a possibility to perform combined treatment and positive experiences in treating patients with trophoblastic tumors.

Keywords

epithelioid tumor
trophoblastic disease
diagnosis

References

  1. Materials of the 17th International Meeting of the European Society of Gynaecological Oncology (ESGO). Milan; 2011.
  2. Goglia U., Vinanzi C., Zuccarello D., Malpassi D., Ameri P., Casu M. et al. Identification of a novel mutation in exon 1 of the androgen receptor gene in an azoospermic patient with mild androgen insensitivity syndrome: case report and literature review. Fertil. Steril. 2011; 96(5): 1165-9.
  3. Consuelo L., Lopes V.S., Rodrigues F.R., Steim J.L. Gestational trophoblastic neoplasia after ectopic molar pregnancy: clinical, diagnostic, and therapeutic aspects CC BY-NC-ND 4.0. Rev. Bras. Ginecol. Obstet. 2018; 40(05): 294-9. DOI: 10.1055/s-0038-1653976.
  4. Lei W., Zhang F., Zheng C., Zhao C., Tu S., Bao Y. Metastatic epithelioid trophoblastic tumor of the lung: A case report. Medicine (Baltimore). 2018; 97(16): e0306. DOI: 10.1097 / MD.0000000000010306
  5. Cools M., Wolffenbuttel K.P., Hersmus R., Mendonca B.B., Kaprová J., Drop S.L. et al. Malignant testicular germ cell tumors in postpubertal individuals with androgen insensitivity: prevalence, pathology and relevance of single nucleotide polymorphism-based susceptibility profiling. Hum. Reprod. 2017; 32(12): 2561-73. doi: 10.1093/humrep/dex300.
  6. Yunusova N.V., Kondakova I.V., Kolomiets L.A., Afanas’ev S.G., Chernyshova A.L., Kudryavtsev I.V., Tsydenova A.A. Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors). Asia Pac. J. Clin. Oncol. 2018; 14(3): 134-40. DOI: 10.1111/ajco.1278
  7. Спирина Л.В., Бочкарева Н.В., Кондакова И.В., Коломиец Л.А., Шашова Е.Е., Коваль В.Д., Чернышова А.Л., Асадчикова О.Н. Регуляция инсулиноподобных факторов роста и NF- B протеасомной системой при раке эндометрия. Молекулярная биология. 2012; 46(3): 452-60. [Spirina L.V., Bochkareva N.V., Kondakova I.V., Kolomiets L.A., Shashova E.E., Koval’ V.D., Chernysheva A.L., Asadchikova O.N. Regulation of insulin-like growth NF-κB proteasome system in endometrial cancer. Mol. Biol.(Mosk.). 2012; 46(3): 452-60. (in Russian)]
  8. Gottlieb B., Beitel L.K., Nadarajah A., Paliouras M., Trifiro M. The androgen receptor gene mutations database (ARDB): 2012 update. Hum. Mutat. 2012; 33(5): 887-94.
  9. Кондакова И.В., Спирина Л.В., Коваль В.Д., Шашова Е.Е., Чойнзонов Е.Л., Иванова Э.В., Коломиец Л.А., Чернышова А.Л., Слонимская Е.М., Усынин Е.А., Афанасьев С.Г. Имотрипсинподобная активность и субъединичный состав проееасом в злокачественных опухолях человека. Молекулярная биология. 2014; 48(3): 444-51. [Kondakova I.V., Spirina L.V.,Koval V.D., Shashova E.E., Choinzonov E.L., Ivanova E.V., Kolomiets L.A.,Chernyshova A.L., Slonimskaya E.M., Usynin E.A., Afanas’ev S.G. Chymotrypsin-like activity and subunit composition of proteasomes in human cancers. Mol. Biol. (Mosk.). 2014; 48(3): 444-51. (in Russian)]
  10. Zhao J.R., Cheng W.W., Wang Y.X., Cai M., Wu W.B., Zhang H.J. Identification of microRNA signature in the progression of gestational trophoblastic disease. Cell Death Dis. 2018; 9(2): 94.
  11. FIGO Сommittee on Gynaecologic Oncology. Int. J. Gynaecol. Obstet. 2009; 105: 103–4.
  12. Materials of the 13th Biennial Meeting of the International of Gynecologic Cancer Society (IGCS). Prague; 2010.

Received 14.06.2018

Accepted 22.06.2018

About the Authors

Chernyshova, Alyona L., MD, professor of RAS, leading researcher, Gynecology Department, Cancer Research Institute, Tomsk National Research Medical Center.
634009, Russia, Tomsk, Kooperativny str. 5. E-mail: alacher@list.ru. Author ID Scopus : 55220758100; Reseacher ID WoS: C-8608-2012; Orcid: 0000-0002-8194-2811; РИНЦ: AuthorID: 557924; SPIN-код автора: 2522-7513.
Kolomiets, Larisa A., MD, professor, head of Gynecology Department, Cancer Research Institute, Tomsk National Research Medical Center. 634009, Russia, Tomsk, Kooperativny str. 5. E-mail: kolomietsla@oncology.ru. Author ID Scopus – 7004921120; Reseacher ID WoS - C-8573-2012; Оrcid.org/0000-0002-6854-8940.
Kishkina, Anastasia Yu., postgraduate, Gynecology Department, Cancer Research Institute, Tomsk National Research Medical Center.
634009, Russia, Tomsk, Kooperativny str. 5.
Ochirov, Maxim O., postgraduate, Gynecology Department, Cancer Research Institute, Tomsk National Research Medical Center.
634009, Russia, Tomsk, Kooperativny str. 5.
Glushchenko, Svetlana A., PhD, doctor of the Department of Pathomorphology, Cancer Research Institute, Tomsk National Research Medical Center.
634009, Russia, Tomsk, Kooperativny str. 5.
Perelmuter, Vladimir M., MD, professor, head of the Department of Pathomorphology, Cancer Research Institute, Tomsk National Research Medical Center.
634009, Russia, Tomsk, Kooperativny str. 5. E-mail: perelmuter@oncology.ru

For citations: Chernyshova A.L., Kolomiets L.A., Kishkina A.Yu., Ochirov M.O., Glushchenko S.A., Perelmuter V.M. The features of clinical course and complexities in the diagnosis of a case of epithelioid trophoblastic disease. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (2): 170-4. (in Russian)
http://dx.doi.org/10.18565/aig.2019.2.170-174

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