The features of clinical course and complexities in the diagnosis of a case of epithelioid trophoblastic disease
Background. Epithelioid trophoblastic tumor was first described by morphologists in 1995; the world literature reports only about 90 cases of this tumor, which confirms its extreme rarity. This type of tumor is characterized by high malignancy and fairly rapid distant metastasis. At the same time, the current chemotherapy regimens, even those for distant metastases, show a good sufficient efficiency.Chernyshova A.L., Kolomiets L.A., Kishkina A.Yu., Ochirov M.O., Glushchenko S.A., Perelmuter V.M.
Clinical case report. The paper analyzes the features of clinical course, diagnostic difficulties, and the observation in epithelioid tumor. It presents difficulties in the interpretation of clinical data and in the differential diagnosis of morphological features in this type of tumor. The authors show the expediency and high informative value of immunohistochemical examination of a tissue specimen.
Conclusion. This category of patients should be examined and treated in specialized clinics that have a possibility to perform combined treatment and positive experiences in treating patients with trophoblastic tumors.
Keywords
epithelioid tumor
trophoblastic disease
diagnosis
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Received 14.06.2018
Accepted 22.06.2018
About the Authors
Chernyshova, Alyona L., MD, professor of RAS, leading researcher, Gynecology Department, Cancer Research Institute, Tomsk National Research Medical Center.634009, Russia, Tomsk, Kooperativny str. 5. E-mail: alacher@list.ru. Author ID Scopus : 55220758100; Reseacher ID WoS: C-8608-2012; Orcid: 0000-0002-8194-2811; РИНЦ: AuthorID: 557924; SPIN-код автора: 2522-7513.
Kolomiets, Larisa A., MD, professor, head of Gynecology Department, Cancer Research Institute, Tomsk National Research Medical Center. 634009, Russia, Tomsk, Kooperativny str. 5. E-mail: kolomietsla@oncology.ru. Author ID Scopus – 7004921120; Reseacher ID WoS - C-8573-2012; Оrcid.org/0000-0002-6854-8940.
Kishkina, Anastasia Yu., postgraduate, Gynecology Department, Cancer Research Institute, Tomsk National Research Medical Center.
634009, Russia, Tomsk, Kooperativny str. 5.
Ochirov, Maxim O., postgraduate, Gynecology Department, Cancer Research Institute, Tomsk National Research Medical Center.
634009, Russia, Tomsk, Kooperativny str. 5.
Glushchenko, Svetlana A., PhD, doctor of the Department of Pathomorphology, Cancer Research Institute, Tomsk National Research Medical Center.
634009, Russia, Tomsk, Kooperativny str. 5.
Perelmuter, Vladimir M., MD, professor, head of the Department of Pathomorphology, Cancer Research Institute, Tomsk National Research Medical Center.
634009, Russia, Tomsk, Kooperativny str. 5. E-mail: perelmuter@oncology.ru
For citations: Chernyshova A.L., Kolomiets L.A., Kishkina A.Yu., Ochirov M.O., Glushchenko S.A., Perelmuter V.M. The features of clinical course and complexities in the diagnosis of a case of epithelioid trophoblastic disease. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (2): 170-4. (in Russian)
http://dx.doi.org/10.18565/aig.2019.2.170-174