About
The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
ArchiveEthical StandardsSubscription
For authors
InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
Reviewing
Procedure for reviewingReviewers 2023-2024
About
The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
ArchiveEthical StandardsSubscription
For authors
InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
Reviewing
Procedure for reviewingReviewers 2023-2024
Logout
Obstetrics and Gynegology2021№12
Predictors of endometriosis in infertility

Predictors of endometriosis in infertility

DOI
https://dx.doi.org/10.18565/aig.2021.12.5-15

Ivshin A.A., Pogodin O.O., Gusev A.V.

1) Petrozavodsk State University, Medical Institute, Department of Obstetrics and Gynecology, Dermatovenereology, Petrozavodsk, Russia; 2) Republican Perinatal Center, Ministry of Health of the Republic of Karelia, Petrozavodsk, Russia; 3) K-Sky LLC, Petrozavodsk, Russia
Endometriosis is a gynecological disease associated with infertility, affecting 6–10% of reproductive-aged women. The current objective diagnosis of endometriosis is based on a visual assessment of abdominal and pelvic organs with obligatory histological verification of surgical materials. Meanwhile, the need for invasive surgery to identify endometrioid heterotopias slows down the diagnostic search, and it takes an average of about seven years from disease onset to diagnosis. Delayed diagnosis of endometriosis is often accompanied by adverse consequences as progression of the disease and development of untreatable infertility. Thus, the identification of significant noninvasive predictors for endometrioid disease, which are associated with infertility, will be able to identify a group of high-risk patients for this pathology and to speed up its diagnosis. According to the literature data studied, the reliable prognostic signs of endometriosis in infertility are premenstrual spotting, primary infertility, the unfavorable course of dysmenorrhea, the presence of nodules in the region of the sacrouterine ligaments or posterior vault, age, the duration of infertility, body mass index, the length of the menstrual cycle, repeated abortions, dyspareunia, chronic pelvic pain, and a family history of endometriosis. The independent predictive factors of severe infertility-associated endometriosis are age, education, the duration of infertility, body mass index, amount of menstrual blood loss, the duration of menstruation, dyspareunia, chronic pelvic pain, and a family history of endometriosis.
Conclusion: The design of special detailed questionnaires and diagnostic programs that are risk classifiers will contribute to the timely identification of patients having the greatest risk of developing endometriosis in infertility, who should mostly undergo immediate laparoscopy.

Keywords

endometriosis
infertility
predictor
risk factor
prognosis
diagnosis
laparoscopy
Full text (in Russian)

References

  1. Оразов М.Р., Радзинский В.Е., Хамошина М.Б., Михалева Л.М., Волкова С.В., Абитова M.З. Причины эндометриоз-ассоциированного бесплодия. Репродуктивная медицина. 2020; 2: 43-8. [Orazov M.R., Radzinsky V.E., Khamoshina M.B., Mikhaleva L.M., Volkova S.V., Abitova M.Z. Reasons for endometriosis-associated infertility. Reproductive medicine. 2020; 2(43): 43-8. (in Russian)]. https://dx.doi.org/10.37800/RM2020-1-17.
  2. Меджидова А.М., Эседова А.Э. Актуальные вопросы диагностики и лечения бесплодия у женщин с внутренним генитальным эндометриозом. Исследования и практика в медицине. 2017; 4(4): 89-98. [Medzhidova A.M., Esedova A.E. Topical issues of diagnosis and treatment of infertility in women with internal genital endometriosis. Research and Practical Medicine Journal. 2017; 4(4): 89-98. (in Russian)]. https://dx.doi.org/10.17709/2409-2231-2017-4-4-10.
  3. Жорова В.Е. Эндометриоз: причины бесплодия и новые методы диагностики. Архив акушерства и гинекологии им. В.Ф. Снегирева. 2017; 4(2): 107-8. [Zhorova V.E. Endometriosis associated infertility and new diagnostic methods. V.F. Snegirev Archives of Obstetrics and Gynecology. 2017; 4(2): 107-8. (in Russian)]. https://dx.doi.org/10.18821/2313-8726-2017-4-2-103-112.
  4. Павловская М.А., Гутикова Л.В., Кухарчик Ю.В., Костяхин А.Е., Кулешова Л.В., Гурин А.Л. Опыт лечения бесплодия у пациентов с наружным генитальным эндометриозом: сравнительная эффективность методов. Журнал Гродненского государственного медицинского университета. 2017; 15(2): 192-7. [Paulouskaya M.A., Gutikova L.V., Kukharchik Yu.V., Kostiahin A.Y., Kuleshova L.G., Gurin A.L. The experience of the treatment of patients with external genital endometriosis: comparative effectiveness of methods. Journal of the Grodno State Medical University. 2017; 15(2): 192-7. (in Russian)].
  5. Коган Е.А., Акопова Е.О., Унанян А.Л. Бесплодие при эндометриозе: краткий очерк современных представлений. Пространство и Время. 2017; 1: 251-9. [Kogan E. A., Akopova A. L., Unayan A. L. Infertility in endometriosis: a brief sketch of modern concepts. Space and Time. 2017; 1(27): 251-9. (in Russian)].
  6. Тезиков Ю.В., Стрижаков А.Н., Липатов И.С., Калинкина О.Б., Аравина О.Р., Амосов М.С. Оптимизация тактики ведения пациенток с эндометриозом яичников и бесплодием. Акушерство и гинекология. 2021; 7: 122-32. [Tezikov Yu.V., Strizhakov A.N., Lipatov I.S., Kalinkina O.B., Aravina O.R., Amosov M.S. Optimizing management strategy in infertile patients with ovarian endometriosis. Obstetrics and Gynecology. 2021; 7: 122-32 (in Russian)]. https://dx.doi.org/10.18565/aig.2021.7.122-132.
  7. Бугеренко К., Ларин К.В., Щербакова Л.Н., Бугеренко А.Е., Проскурнина Е.В., Панина О.Б. Причины снижения овариального резерва при эндометриоидных кистах яичников. Вопросы гинекологии, акушерства и перинатологии. 2018; 17(4): 25-30. [Bugerenko K.A., Larin K.V., Shcherbakova L.N., Bugerenko A.Ye., Proskurnina Ye.V., Panina O.B. Causes of ovarian reserve reduction in endometrioid ovarian cysts. Questions of Gynecology, Obstetrics and Perinatology. 2018; 17(4): 25-30. (in Russian)]. https://dx.doi.org/10.20953/1726-1678-2018-4-25-30.
  8. Адамян Л.В., Мартиросян Я.О., Асатурова А.В. Этиопатогенез эндометриоз-ассоциированного бесплодия (обзор литературы). Проблемы репродукции. 2018; 24(2): 28-33 [Adamyan L.V., Martirosyan Ya.O., Asaturova A.V. Etiopathogenesis of endometriosis-associated infertility (a review). Problems of Reproduction. 2018; 24(2): 28-33. (in Russian)]. https://dx.doi.org/10.20953/1726-1678-2018-4-25-30.
  9. Дубинская Е.Д., Лаптева Н.В. Клинико-анамнестические и генетические особенности пациенток с бесплодием и перитонеальной формой эндометриоза. Академический журнал Западной Сибири. 2013; 9(4): 36-7. [Dubinskaya E. D., Lapteva N. V. Clinical-anamnestic and genetic features in infertile patients with peritoneal endometriosis. Academic Journal of West Siberia. 2013; 4(47): 36-7. (in Russian)].
  10. Чупрынин В.Д., Мельников М.В., Вуралкина Н.А., Чурсин В.В., Вередченко А.В., Бурыкина П.Н., Хилькевич Е.Г., Гус А.И., Павлович С.В. Современные представления о тактике ведения больных с инфильтративным эндометриозом. Акушерство и гинекология. 2015; 11: 16-22. [Chuprynin V.D., Melnikov M.V., Buralkina N.A., Chursin V.V., Veredchenko A.V., Burykina P.N., Khilkevich E.G., Gus A.I., Pavlovich S.V. Current ideas on management tactics for patients with infiltrating endometriosis. Akusherstvo i Obstetrics and Gynecology. 2015; 11: 16-22. (in Russian)].
  11. Альмова И.К., Хилькевич Е.Г., Чупрынин В.Д., Тихомирова А.А., Асатурова А.В., Чурсин В.В. Клинические и диагностические особенности ретроцервикального эндометриоза. Акушерство и гинекология. 2018; 6: 45-53. [Almova I.K., Khilkevich E.G., Chuprynin V.D., Tikhomirova A.A., Asaturova A.V., Chursin V.V. Clinical and diagnostic features of retrocervical endometriosis. Obstetrics and Gynecology. 2018; 6: 45-53. (in Russian)]. https://dx.doi.org/10.18565/aig.2018.6.45-53.
  12. Гущин В.А., Бичурина А.С., Коряушкина А.В. Генитальный эндометриоз, диагностика и лечение. Журнал акушерства и женских болезней. 2017; 66(Спецвыпуск): 106-7. [Guschin V.A., Bichurina A.S., Koryaushkina A.V. Genital endometriosis: diagnosis and treatment. Journal of obstetrics and women’s diseases. 2017; 66 (Special Issue): 106-7. (in Russian)].
  13. Сафронова А.С., Высоких М.Ю., Чупрынин В.Д., Буралкина Н.А. Современные молекулярно-биологические аспекты эндометриоз-ассоциированного бесплодия. Гинекология. 2019; 21(5): 12-5. [Safronova A.S., Vysokikh M.Yu., Chuprynin V.D., Buralkina N.A. Modern molecular and biological aspects of endometriosis-associated infertility. Gynecology. 2019; 21(5): 12-5. (in Russian)]. https://dx.doi.org/10.26442/20795696.2019.5.190731.
  14. Саидданеш Ш.Ф., Чупрынин В.Д., Хилькевич Е.Г., Буралкина Н.А., Павлович С.В., Данилов А.Ю., Чурсин В.В. Современные методы диагностики распространенных форм эндометриоза. Акушерство и гинекология. 2017; 5: 39-43. [Saiddanesh Sh.F., Chuprynin V.D., Khilkevich E.G., Buralkina N.A., Pavlovich S.V., Danilov A.Yu., Chursin V.V. Current methods for diagnosing the common forms of endometriosis. Obstetrics and Gynecology. 2017; 5: 39-43. (in Russian)]. https://dx.doi.org/10.18565/aig.2017.5.39-43.
  15. Лисовская Е.В., Хилькевич Е.Г., Чупрынин В.Д., Мельников М.В., Ипатова М.В. Качество жизни женщин с глубоким инфильтративным эндометриозом. Акушерство и гинекология. 2020; 3: 116-26. [Lisovskaya E.V., Khilkevich E.G., Chuprynin V.D., Melnikov M.V., Ipatova M.V. Quality of life in patients with deep infiltrating endometriosis. Obstetrics and gynecology. 2020; 3: 116-26. (in Russian)] https://dx.doi.org/10.18565/aig.2020.3.116-126.
  16. Межлумова Н.А., Бобров М.Ю., Адамян Л.В. Биомаркеры эндометриоза: проблемы и возможности ранней диагностики рецидивов заболевания (обзор литературы). Проблемы репродукции. 2018; 24(6): 139-48. [Mezhlumova N.A., Bobrov M.Yu., Adamyan L.V. Biomarkers of endometriosis: problems and possibilities of early detection of disease recurrence (a review). Problems of Reproduction. 2018; 24(6): 139-48. (in Russian)]. https://dx.doi.org/10.17116/repro201824061139.
  17. Русина Е.И., Ярмолинская М.И., Иванова А.О. Современные подходы при лучевой диагностике эндометриоза. Журнал акушерства и женских болезней. 2020; 69(2): 59-72. [Rusina E.I., Yarmolinskaya M.I., Ivanova A.O. Modern methods for radiological diagnosis of endometriosis. Journal of Obstetrics and Women’s Diseases. 2020; 69(2): 59-72. (in Russian)]. https://dx.doi.org/10.17816/JOWD69259-72.
  18. Сандакова Е.А., Чистякова Д.М., Ваганова А.Ф., Ракитина Ю.В. Роль магнитно-резонансной томографии в диагностике генитального эндометриоза у женщин репродуктивного возраста. Пермский медицинский журнал. 2019; 36(5): 21-6. https://dx.doi.org/10.17816/pmj36521-26. [Sandakova E.A., Chistyakova D.M., Vaganova A.F., Rakitina Y.V. Role of magnetic resonance tomography in diagnosis of genital endometriosis among women of reproductive age. Perm Medical Journal. 2019; 36(5): 21-6. (in Russian)]. https://dx.doi.org/10.17816/pmj36521-26.
  19. Гончарова М.А., Петров Ю.А., Кислякова Н.Н. Генитальный эндо­мет­риоз: основные направления диагностики и лечения. Научное обозрение. Медицинские науки. 2020; 2: 5-9. [Goncharova M.A., Petrov Y.A., Kislyakova N.N. Genital endometriosis: basic directions of diagnostics and treatment. Medical sciences. 2020; 2: 5-9. (in Russian)].
  20. Альмова И.К., Хилькевич Е.Г., Чупрынин В.Д., Балашов И.С., Гус А.С., Быченко В.А., Матроницкий Р.Б., Серов В.Н. Сравнительнаый анализ методов диагностики ретроцервикального эндометриоза. Акушерство и гинекология. 2019; 10: 129-39. [Almova I.K., Khilkevich E.G., Chuprynin V.D., Balashov I.S., Gus A.S., Bychenko V.A, Matronitsky R.B, Serov V.N. Comparative analysis of techniques for diagnosing retrocervical endometriosis. Obstetrics and Gynecology. 2019; 10:129-39. (in Russian)]. https://dx.doi.org/10.18565/aig.2019.10.129-139.
  21. Баринов С.В., Лазарева О.В., Игнатьев Ю.Т., Полуэктов В.Л., Мозговой С.И., Шамина И.В., Ледовских И.О., Шкабарня Л.Л., Полуэктов В.В., Овчинникова К.Г. Клиническое значение методов диагностики генитального эндометриоза. Акушерство и гинекология. 2018; 12: 75-81. [Barinov S.V., Lazareva O.V., Ignatyev Y.T., Poluektov V.L., Mozgovoy S.I., Shamina I.V., Ledovskih O.I., Shkabarnya L.L., Poluektov V.V., Ovchinnikova K.G. Clinical significance of diagnostic methods of genital endometriosis. Obstetrics and Gynecology. 2018; 12: 75-81. (in Russian)]. https://dx.doi.org/10.18565/aig.2018.12.75-81.
  22. Howard F.M. The role of laparoscopy in chronic pelvic pain: Promise and pitfalls. Obstet. Gynecol. Surv. 1993; 48(6): 357-87. https://dx.doi.org/10.1097/00006254-199306000-00001.
  23. Cox L., Ayers S., Nala K., Penny J. Chronic pelvic pain and quality of life after laparoscopy. Eur. J. Obstet. Gynecol. Reprod. Biol. 2007; 132(2): 214-19. https://dx.doi.org/10.1016/j.ejogrb.2006.04.020.
  24. Fedele L., Bianchi S., Bocciolone L., Di Nola G., Parazzini F. Pain symptoms associated with endometriosis. Obstet. Gynecol. 1992; 79(5): 767-9.
  25. Matorras R., Rodríguez F., Pijoan J.I., Soto E., Pérez C., Ramón O., Rodríguez-Escudero F. Are there any clinical signs and symptoms that are related to endometriosis in infertile women? Am. J. Obstet. Gynecol. 1996; 174(2): 620-3. https://dx.doi.org/10.1016/S0002-9378(96)70438-6.
  26. Positive predictive value of clinical diagnosis of endometriosis. PubMed. Accessed Apr. 20, 2021. [Online]. Available at: https://pubmed.ncbi.nlm.nih.gov/15521226/
  27. Nezhat C., Littman E.D., Lathi R.B., Berker B., Westphal L.M., Giudice L.C., Milki A.A. The dilemma of endometriosis: Is consensus possible with an enigma? Fertil. Steril. 2005; 84(6): 1587-8. https://dx.doi.org/10.1016/j.fertnstert.2005.06.033.
  28. Olive D.L., Pritts E.A. The treatment of endometriosis: A review of the evidence. Ann. N. Y. Acad. Sci. 2002; 955: 360-72; discussion 389-93, 396-406. https://dx.doi.org/10.1111/j.1749-6632.2002.tb02797.x.
  29. Moini A., Malekzadeh F., Amirchaghmaghi E., Kashfi F., Akhoond M.R., Saei M., Mirbolok M.H. Risk factors associated with endometriosis among infertile Iranian women. Arch. Med. Sci. 2013; 9(3): 506-14. https://dx.doi.org/10.5114/aoms.2013.35420.
  30. Calhaz-Jorge C., Mol B.W., Nunes J., Costa A.P. Clinical predictive factors for endometriosis in a Portuguese infertile population. Hum. Reprod. 2004; 19(9): 2126-31. https://dx.doi.org/10.1093/humrep/deh374.
  31. Missmer S.A., Hankinson S.E., Spiegelman D., Barbieri R.L., Marshall L.M., Hunter D.J. Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors. Am. J. Epidemiol. 2004; 160(8): 784-96. https://dx.doi.org/10.1093/aje/kwh275.
  32. Gruppo Italiano per lo Studio dell' endometriosis. Risk factors for pelvic endometriosis in women with pelvic pain or infertility. Eur. J. Obstet. Gynecol. Reprod. Biol. 1999; 83(2): 195-9. https://dx.doi.org/10.1016/S0301-2115(98)00332-7.
  33. Hediger M.L., Hartnett H.J., Louis G.M.B. Association of endometriosis with body size and figure. Fertil. Steril. 2005; 84(5): 1366-74. https://dx.doi.org/10.1016/j.fertnstert.2005.05.029.
  34. Bérubé S., Marcoux S., Maheux R. Characteristics related to the prevalence of minimal or mild endometriosis in infertile women. Epidemiology. 1998; 9(5): 504-10. https://dx.doi.org/10.1097/00001648-199809000-00006.
  35. Yi K.W., Shin J.H., Park M.S., Kim T., Kim S.H., Hur J.Y. Association of body mass index with severity of endometriosis in Korean women. Int. J. Gynaecol. Obstet. 2009; 105(1): 39-42. https://dx.doi.org/10.1016/j.ijgo.2008.11.001.
  36. Arumugam K., Lim J.M.H. Menstrual characteristics associated with endometriosis. Br. J. Obste.t Gynaecol. 1997; 104(8): 948-50. https://dx.doi.org/10.1111/j.1471-0528.1997.tb14357.x.
  37. Cramer D.W., Missmer S.A. The epidemiology of endometriosis. Ann. N. Y. Acad. Sci. 2002; 955: 11-22. https://dx.doi.org/10.1111/j.1749-6632.2002.tb02761.x.
  38. Hemmings R., Rivard M., Olive D.L., Poliquin-Fleury J., Gagné D., Hugo P., Gosselin D. Evaluation of risk factors associated with endometriosis. Fertil. Steril. 2004; 81(6): 1513-21. https://dx.doi.org/10.1016/j.fertnstert.2003.10.038.
  39. Mamdouh H.M., Mortada M.M., Kharboush I.F., Abd-Elateef H.A.E. Epidemiologic determinants of endometriosis among Egyptian women: A hospital-based case-control study. J. Egypt. Public Health Assoc. 2011; 86(1-2):21-6. https://dx.doi.org/10.1097/01.EPX.0000395322.91912.56.
  40. Matalliotakis I.M., Arici A., Cakmak H., Goumenou A.G., Koumantakis G., Mahutte N.G. Familial aggregation of endometriosis in the Yale Series. Arch. Gynecol. Obstet. 2008; 278(6): 507-11. https://dx.doi.org/10.1007/s00404-008-0644-1.
  41. Kashima K., Ishimaru T., Okamura H., Suginami H., Ikuma K., Murakami T. et al. Familial risk among Japanese patients with endometriosis. Int. J. Gynaecol Obstet. 2004; 84(1): 61-4. https://dx.doi.org/10.1016/S0020-7292(03)00340-0.
  42. Heitmann R.J., Langan K.L., Huang R.R., Chow G.E., Burney R.O. Premenstrual spotting of ≥2 days is strongly associated with histologically confirmed endometriosis in women with infertility. Am. J. Obstet. Gynecol. 2014; 211(4): 358.e1--358.e6. https://dx.doi.org/10.1016/j.ajog.2014.04.041.
  43. Wentz A.C. Premenstrual spotting: Its association with endometriosis but not luteal phase inadequacy. Fertil. Steril. 1980; 33(6): 605-7. https://dx.doi.org/10.1016/S0015-0282(16)44772-2.
  44. Endometriosis symptoms and the limitations of pathology-based classification of severity. PubMed. Accessed Apr. 20, 2021. [Online]. Available at: https://pubmed.ncbi.nlm.nih.gov/8099024/
  45. Whitehill K., Yong P.J., Williams C. Clinical predictors of endometriosis in the infertility population: Is there a better way to determine who needs a laparoscopy? J. Obstet. Gynaecol. Can. 2012; 34(6): 552-7. https://dx.doi.org/10.1016/S1701-2163(16)35271-9.
  46. Carmona F., Chapron C., Martínez-Zamora M.Á., Santulli P., Rabanal A., Martínez-Florensa M. et al. Ovarian endometrioma but not deep infiltrating endometriosis is associated with increased serum levels of interleukin-8 and interleukin-6. J. Reprod. Immunol. 2012; 95(1-2): 80-6. https://dx.doi.org/10.1016/j.jri.2012.06.001.
  47. Carp H.J.A., Selmi C., Shoenfeld Y. The autoimmune bases of infertility and pregnancy loss. J. Autoimmun. 2012; 38(2-3): J266-74. https://dx.doi.org/10.1016/j.jaut.2011.11.016.
  48. Gica N., Panaitescu A.M., Iancu G., Botezatu R., Peltecu G., Gica C. The role of biological markers in predicting infertility associated with non-obstructive endometriosis. Ginekol. Pol. 2020; 91(4): 189-92. https://dx.doi.org/10.5603/GP.2020.0039.
  49. May K.E., Conduit-Hulbert S.A., Villar J., Kirtley S., Kennedy S.H., Becker C.M. Peripheral biomarkers of endometriosis: A systematic review. Hum. Reprod. Update. 2010; 16(6): 651-74. https://dx.doi.org/10.1093/humupd/dmq009.
  50. Othman E.E.D.R., Hornung D., Salem H.T., Khalifa E.A., El-Metwally T.H., Al-Hendy A. Serum cytokines as biomarkers for nonsurgical prediction of endometriosis. Eur. J.. Obstet Gynecol. Reprod. Biol. 2008; 137(2): 240-6. https://dx.doi.org/10.1016/j.ejogrb.2007.05.001.
  51. Bedaiwy M.A., Falcone T., Sharma R.K., Goldberg J.M., Attaran M., Nelson D.R., Agarwal A. Prediction of endometriosis with serum and peritoneal fluid markers: A prospective controlled trial. Hum. Reprod. 2002, 17(2):426-31. https://dx.doi.org/10.1093/humrep/17.2.426.
  52. Ohata Y., Harada T., Miyakoda H., Taniguchi F., Iwabe T., Terakawa N. Serum interleukin-8 levels are elevated in patients with ovarian endometrioma. Fertil. Steril. 2008; 90(4): 994-9. https://dx.doi.org/10.1016/j.fertnstert.2007.07.1355.
  53. Pizzo A., Salmeri F.M., Ardita F.V., Sofo V., Tripepi M., Marsico S. Behaviour of cytokine levels in serum and peritoneal fluid of women with endometriosis. Gynecol. Obstet. Invest. 2002; 54(2): 82-7. https://dx.doi.org/10.1159/000067717.
  54. Fassbender A., Burney R.O., Dorien F.O., D’Hooghe T., Giudice L. Update on biomarkers for the detection of endometriosis. Biomed. Res. Int. 2015; 2015: 130854. https://dx.doi.org/10.1155/2015/130854.

Received 01.09.2021

Accepted 08.11.2021

About the Authors

Aleksandr A. Ivshin, PhD, Associate Professor, Head of the Department of Obstetrics and Gynecology and Dermatovenerology, Petrozavodsk State University,
+7(909)567-12-51, scipeople@mail.ru, https://orcid.org/0000-0001-7834-096X, 31, Krasnoarmeyskaya st., Petrozavodsk, Republic of Karelia, 185001, Russia.
Oleg O. Pogodin, Obstetrician-Gynecologist, Head of the Gynecological Department, Republican Perinatal Center of the Ministry of Health of the Republic of Karelia, +7(921)227-82-85, opogodin@gmail.com, 9, Syktyvkarskaya str., Petrozavodsk, Republic of Karelia, 185002, Russia.
Aleksandr V. Gusev, PhD (Engineering Sciences), Сhief business development officer, K-Skai LLC, +7(911)402-35-00, agusev@webiomed.ai,
https://orcid.org/0000-0002-7380-846017, 17 (of. 62/20), nab. Varkausa, Petrozavodsk, Republic of Karelia, 185031, Russia.
Corresponding author: Aleksandr A. Ivshin, scipeople@mail.ru

Authors’ contributions: Ivshin A.A., Pogodin O.O., Gusev A.V. – reviewing publications on the topic of the article, analyzing the findings, writing the manuscript.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has been conducted with financial support from the Ministry of Science and Higher Education of the Russian Federation under Agreement No. 075-15-2021-665. The study was carried out on a unique scientific installation “Multicomponent software and hardware complex for automated collection, storage, labeling of research and clinical biomedical data, their unification and analysis based on a data center using artificial intelligence technologies” (Reg. No. 2075518).
For citation: Ivshin A.A., Pogodin O.O., Gusev A.V.
Predictors of endometriosis in infertility.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 12: 5-15 (in Russian)
https://dx.doi.org/10.18565/aig.2021.12.5-15

Similar Articles

№9 / 2024
Chekeneva N.A., Dumanovskaya M.R., Chuprynin V.D., Asaturova A.V., Buralkina N.A.
Comprehensive approach to the management of patients with endometriosis‑associated infertility using the fertility index
№10 / 2024
Kondratovich L.M., Chursin V.V., Dzhabiev A.V., Chuprynin V.D., Badlaeva A.S.
Heterotopic pregnancy after surgical treatment of colorectal endometriosis
№10 / 2024
Tezikov Yu.V., Lipatov I.S., Amosov M.S.
Pathogenetic features of the preclinical stage ofgestational complications in women with endometriosis
№9 / 2024
Bezhenar V.F., Kuzmina N.S., Kruglov S.Yu., Gramatikova A.G., Izorkina V.A., Medvedeva I.V., Demidov A.D., Strukova D.S., Fedosova D.V., Barnash I.A.
Differentiated approaches to the development of prolonged treatment regimens for patients with endometriosis in the postoperative period
№8 / 2024
Dubinskaya E.D., Kolesnikova S.N., Alyoshkina E.V., Gasparov A.S.
Clinical risk factors for infertility in reproductive-age patients with intramural uterine fibroids
By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.