Predictors of endometriosis in infertility

DOI

https://dx.doi.org/10.18565/aig.2021.12.5-15

Ivshin A.A., Pogodin O.O., Gusev A.V.
1) Petrozavodsk State University, Medical Institute, Department of Obstetrics and Gynecology, Dermatovenereology, Petrozavodsk, Russia; 2) Republican Perinatal Center, Ministry of Health of the Republic of Karelia, Petrozavodsk, Russia; 3) K-Sky LLC, Petrozavodsk, Russia

Endometriosis is a gynecological disease associated with infertility, affecting 6–10% of reproductive-aged women. The current objective diagnosis of endometriosis is based on a visual assessment of abdominal and pelvic organs with obligatory histological verification of surgical materials. Meanwhile, the need for invasive surgery to identify endometrioid heterotopias slows down the diagnostic search, and it takes an average of about seven years from disease onset to diagnosis. Delayed diagnosis of endometriosis is often accompanied by adverse consequences as progression of the disease and development of untreatable infertility. Thus, the identification of significant noninvasive predictors for endometrioid disease, which are associated with infertility, will be able to identify a group of high-risk patients for this pathology and to speed up its diagnosis. According to the literature data studied, the reliable prognostic signs of endometriosis in infertility are premenstrual spotting, primary infertility, the unfavorable course of dysmenorrhea, the presence of nodules in the region of the sacrouterine ligaments or posterior vault, age, the duration of infertility, body mass index, the length of the menstrual cycle, repeated abortions, dyspareunia, chronic pelvic pain, and a family history of endometriosis. The independent predictive factors of severe infertility-associated endometriosis are age, education, the duration of infertility, body mass index, amount of menstrual blood loss, the duration of menstruation, dyspareunia, chronic pelvic pain, and a family history of endometriosis.
Conclusion: The design of special detailed questionnaires and diagnostic programs that are risk classifiers will contribute to the timely identification of patients having the greatest risk of developing endometriosis in infertility, who should mostly undergo immediate laparoscopy.

endometriosis

infertility

predictor

risk factor

prognosis

diagnosis

laparoscopy

Full text (in Russian)

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Received 01.09.2021

Accepted 08.11.2021

Aleksandr A. Ivshin, PhD, Associate Professor, Head of the Department of Obstetrics and Gynecology and Dermatovenerology, Petrozavodsk State University,
+7(909)567-12-51, scipeople@mail.ru, https://orcid.org/0000-0001-7834-096X, 31, Krasnoarmeyskaya st., Petrozavodsk, Republic of Karelia, 185001, Russia.
Oleg O. Pogodin, Obstetrician-Gynecologist, Head of the Gynecological Department, Republican Perinatal Center of the Ministry of Health of the Republic of Karelia, +7(921)227-82-85, opogodin@gmail.com, 9, Syktyvkarskaya str., Petrozavodsk, Republic of Karelia, 185002, Russia.
Aleksandr V. Gusev, PhD (Engineering Sciences), Сhief business development officer, K-Skai LLC, +7(911)402-35-00, agusev@webiomed.ai,
https://orcid.org/0000-0002-7380-846017, 17 (of. 62/20), nab. Varkausa, Petrozavodsk, Republic of Karelia, 185031, Russia.
Corresponding author: Aleksandr A. Ivshin, scipeople@mail.ru

Authors’ contributions: Ivshin A.A., Pogodin O.O., Gusev A.V. – reviewing publications on the topic of the article, analyzing the findings, writing the manuscript.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has been conducted with financial support from the Ministry of Science and Higher Education of the Russian Federation under Agreement No. 075-15-2021-665. The study was carried out on a unique scientific installation “Multicomponent software and hardware complex for automated collection, storage, labeling of research and clinical biomedical data, their unification and analysis based on a data center using artificial intelligence technologies” (Reg. No. 2075518).
For citation: Ivshin A.A., Pogodin O.O., Gusev A.V.
Predictors of endometriosis in infertility.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 12: 5-15 (in Russian)
https://dx.doi.org/10.18565/aig.2021.12.5-15

Predictors of endometriosis in infertility

Ivshin A.A., Pogodin O.O., Gusev A.V.

Keywords

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