Gene expression features in patients with genital prolapse

Cheremin M.M., Smolnova T.Yu., Krasnyi A.M., Chuprynin V.D.

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia

Genital prolapse is a serious problem affecting the female population due to its high prevalence and absence of prerequisites to the decrease in its rate at the moment. Since the genetic aspect is critically important for understanding the pathogenesis of genital prolapse, the databases and services, namely PubMed, Google Scholar, and eLibrary have been searched for the findings on the features of the gene expression of connective tissue components in patients with genital prolapse, as well as epigenomic influence and interactions of extracellular matrix components. The development of genital prolapse can be influenced by the following factors: mRNA expression of collagen and elastic fibers, homeostasis of these fibers among the components of the interstitial substance, and the state of the interstitial substance itself (decorin (DCN), biglycan (BGN), fibromodulin (FMO) and lumican (LUM)), as well as modeling, degradation and remodeling of other components of the extracellular matrix. The review also highlights the important role of the smooth muscle component and the effect of the expression level of a number of genes on its functionality.
Conclusion: The review identified a wide range of links in molecular genetic and biochemical processes and their changes which can result in genital prolapse. However, most of these processes are not specific; therefore, in the future it is necessary to continue the search for molecular genetic causes that play a role in the pathogenesis of genital prolapse.

Authors’ contributions: Cheremin M.M. – collection of literary sources, analysis of literary data, writing the article; 
Smolnova T.Yu. – analysis of the Russian and foreign literature, editing the text; Krasnyi A.M. – analysis of foreign literature, editing the text; Chuprynin V.D. – editing the text.
Conflicts of interest: The authors declare no conflicts of interest.
Funding: The study was conducted without sponsorship.
For citation: Cheremin M.M., Smolnova T.Yu., Krasnyi A.M., Chuprynin V.D. Gene expression features in patients with genital prolapse.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (3): 50-56 (in Russian)


genital prolapse
gene expression
connective tissue dysplasia
extracellular matrix
tissue inhibitor of metalloproteinase
smooth muscle cells
transforming growth factor
lysyl oxidase
calcium channels


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Received 25.01.2024

Accepted 13.02.2024

About the Authors

Mikhail M. Cheremin, post-graduate student, Academician V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, 117997, Russia, Moscow, Academician Oparin str., 4,,
Tatyana Yu. Smolnova, Dr. Med. Sci., Senior Researcher at the Department of General Surgery, Academician V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, 117997, Russia, Moscow, Academician Oparin str., 4,,
Alexey M. Krasnyi, PhD, Head of the Cytology Laboratory, Academician V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, 117997, Russia, Moscow, Academician Oparin str., 4,,
Vladimir D. Chuprynin, PhD, Head of the Department of Surgery, Academician V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, 117997, Russia, Moscow, Academician Oparin str., 4,,

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