Features of formation of the fetoplacental complex following transfer of fresh and vitrified embryos in in vitro fertilization programs

Shumovskaya V.V., Putilova N.V., Mazurov D.O.

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia, Yekaterinburg
The paper gives an update on the relationship between genetically determined hemostasiological disorders and the expression level of proangiogenic factors in the formation of the fetoplacental complex and analyzes obstetric and perinatal outcomes following transfer of fresh and vitrified embryos in in vitro fertilization programs based on the data available in the Russian and foreign scientific literature. It shows the role of hemostasiological and proangiogenic factors in the formation of the fetoplacental complex and analyzes obstetric and perinatal outcomes after transfer of fresh and vitrified embryos in in vitro fertilization programs. The authors describe the role of vascular endothelial growth factor and the vascular anticoagulant annexin V in the formation of the placental vascular network that is of particular interest in using the methods of assisted reproductive medicine as the major organ that ensures fetal formation and growth. Further studies will help identify genetic and phenotypic risk factors for placental insufficiency following transfer of fresh and vitrified embryos in in vitro fertilization programs during both hormone replacement therapy and a natural cycle, which will be able to assess perinatal outcomes and to contribute to their improvement.


assisted reproductive technologies
in vitro fertilization
transfer of fresh and vitrified embryos
placental insufficiency
vascular endothelial growth factor
annexin V


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Received 01.02.2018

Accepted 02.03.2018

About the Authors

Shumovskaya, Victoria V., obstetrician gynecologist, post-graduate student, Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia.
620028, Russia, Yekaterinburg, Repina str. 1. Tel.: +79090103341. E-mail: shumvictory@mail.ru
Putilova, Natalia V., MD, Associate Professor, Head of antenatal protection of the fetus, Ural Research Institute of Maternal and Infant Care,
Ministry of Health of Russia. 620028, Russia, Yekaterinburg, Repina str. 1. Tel.: +79222095490. E-mail: putilova-1959@mail.ru
Mazurov, Dmitrii O., PhD, obstetrician gynecologist, head of the department, Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia.
620028, Russia, Yekaterinburg, Repina str. 1. Tel.: +73433581633. E-mail: dmazurov@mail.ru

For citations: Shumovskaya V.V., Putilova N.V., Mazurov D.O. Features of formation of the fetoplacental complex following transfer of fresh and vitrified embryos in in vitro fertilization programs. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (10): 20-4. (in Russian)

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