Specific features of diagnosis and treatment in pregnant women with uncomplicated urinary tract infection and urogenital infections
Urinary disorders in women with recurrent urinary tract infections (UTI) are a serious problem that has not yet been solved despite that there are a large number of papers on this topic. Pregnant women who have experienced acute urinary tract infection and those who have been treated for asymptomatic bacteriuria should be followed up until delivery, by examining their urine to prove the efficiency of antibacterial therapy that can threaten their pregnancy. It is necessary to emphasize the importance of prevention, timely detection of signs of UTI in pregnant women and the correct choice of antibiotic therapy in the developed UTI.Gadzhieva Z.K., Gomberg M.A., Grigoryan V.A., Gazimiev M.A., Kazilov Yu.B.
Keywords
References
1. Аляев Ю.Г., Глыбочко П.В., Пушкарь Д.Ю., ред. Урология. Российские клинические рекомендации. М.; 2018: 501-18.
2. Логутова Л.С., ред. Тактика ведения беременных с хронической болезнью почек и бактериурией. Пособие для врачей. М.; 2012.
3. Клинические рекомендации Европейской ассоциации урологов, 2017. М.; 2017. 1224с.
4. Глыбочко П.В., Аляев Ю.Г., ред. Интегративная урология. Руководство для врачей. М.: Медфорум; 2014. 432с.
5. Kazemier B.M., Koningstein F.N., Schneeberger C., Ott A., Bossuyt P.M., de Miranda E. et al. Maternal and neonatal consequences of treated and untreated asymptomatic bacteriuria in pregnancy: a prospective cohort study with an embedded randomised controlled trial. Lancet Infect. Dis. 2015; 15(11): 1324-33. http://dx.doi.org/10.1016/S1473-3099(15)00070-5
6. Widmer M., Lopez I., Gülmezoglu A.M., Mignini L., Roganti A. Duration of treatment for asymptomatic bacteriuria during pregnancy. Cochrane Database Syst. Rev. 2015; (11): CD000491. https://www.ncbi.nlm.nih.gov/pubmed/26560337
7. Синякова Л.А., Косова И.В. Инфекции мочевых путей у беременных. Современные подходы к лечению. Эффективная фармакотерапия. 2008; 12: 6-13.
8. Kresken M., Körber-Irrgang B., Biedenbach D.J., Batista N., Besard V., Cantón R. et al. Comparative in vitro activity of oral antimicrobial agents against Enterobacteriaceae from patients with community-acquired urinary tract infections in three European countries. Clin. Microbiol. Infect. 2016; 22(1): 63. e1-63. e5.
9. Мавров Г.И., Пиньковская Л.И. Лечение гонореи и неспецифических инфекций мочевыводящих путей цефиксимом (обзор литературы и собственные исследования). Украинский журнал дерматологии, венерологии, косметологии. 2014; 4: 66-72.
10. Гаджиева З.К., Казилов Ю.Б. Особенности подхода к диагностике и лечению рецидивирующих инфекций нижних мочевыводящих путей. Урология. 2013; 3 (Приложение 3): 15-34.
11. Козырев Ю.В. Бессимптомная бактериурия у беременных: лечебно-диагностические аспекты: автореф. дис. … канд. мед. наук. М.; 2013.
12. Ahmadi A., Khodabandehloo M., Ramazanzadeh R., Farhadifar F., Nikkhoo B., Soofizade N., Rezaii M. Association between Ureaplasma urealyticum endocervical infection and spontaneous abortion. Iran. J. Microbiol. 2014; 6(6): 392-7.
13. Taylor-Robinson D. Mollicutes in vaginal microbiology: Mycoplasma hominis, Ureaplasma urealyticum, Ureaplasma parvum and Mycoplasma genitalium. Res. Microbiol. 2017; 168(9-10): 875-81.
14. Cox C., Watt A.P., McKenna J.P., Coyle P.V. Mycoplasma hominis and Gardnerella vaginalis display a significant synergistic relationship in bacterial vaginosis. Eur. J. Clin. Microbiol. Infect. Dis. 2016; 35(3): 481-7.
15. Haahr T., Jensen J.S., Thomsen L., Duus L., Rygaard K., Humaidan P. Abnormal vaginal microbiota may be associated with poor reproductive outcomes: a prospective study in IVF patients. Hum. Reprod. 2016; 31(4): 795-803.
16. Leli C., Meucci M., Vento S., D’Alò F., Farinelli S., Perito S. et al. Microbial and vaginal determinants influencing Mycoplasma hominis and Ureaplasma urealyticum genital colonization in a population of female patients. Infez. Med. 2013; 21(3): 201-6.
17. Allen-Daniels M.J., Serrano M.G., Pflugner L.P., Fettweis J.M., Prestosa M.A., Koparde V.N. et al. Identification of a gene in Mycoplasma hominis associated with preterm birth and microbial burden in intraamniotic infection. Am. J. Obstet. Gynecol. 2015; 212(6): 779. e1-779. e13.
18. Taylor-Robinson D., Jensen J.S., Svenstrup H., Stacey C.M. Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int. J. STD AIDS. 2012; 23: 18-24.
19. De Francesco M.A., Caracciolo S., Bonfanti C., Manca N. Incidence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum isolated in Brescia, Italy, over 7 years. J. Infect. Chemother. 2013;19(4): 621-7.
20. Ye G., Jiang Z., Wang M., Huang J., Jin G., Lu S. The resistance analysis of Ureaplasma urealyticum and Mycoplasma hominis in female reproductive tract specimens. Cell Biochem. Biophys. 2014; 68(1): 207-10.
21. Zhou Y.H., Ma H.X., Yang Y., Gu W.M. Prevalence and antimicrobial resistance of Ureaplasma spp. and Mycoplasma hominis isolated from semen samples of infertile men in Shanghai, China from 2011 to 2016. Eur. J. Clin. Microbiol. Infect. Dis. 2018; 37(4): 729-34. doi: 10.1007/s10096-017-3167-5.
22. Maraki S., Mavromanolaki V., Nioti E., Stafylaki D., Minadakis G. Prevalence and antimicrobial susceptibility of Ureaplasma species and Mycoplasma hominis in Greek female outpatients, 2012-2016. J. Chemother. 2018; 30(3): 140-4. doi:10.1080/1120009X.2017.1404287.
23. Jensen J.S., Cusini M., Gomberg M., Moi H. European guideline on Mycoplasma genitalium infections. J. Eur. Acad. Dermatol. Venereol. 2016; 30(10): 1650-6. doi: 10.1111/jdv.13849.
24. Manhart L.E., Gillespie C.W., Lowens M.S., Khosropour C.M., Colombara D.V., Golden M.R. et al. Standard treatment regimens for nongonococcal urethritis have similar but declining cure rates: a randomized controlled trial. Clin. Infect. Dis. 2013; 56(7): 934-42.
25. Horner P., Blee K., Adams E. Time to manage Mycoplasma genitalium as an STI: but not with azithromycin 1 g! Curr. Opin. Infect. Dis. 2014; 27(1): 68-74.
26. Gesink D.C., Mulvad G., Montgomery-Andersen R., Poppel U., Monrgomery-Andersen S., Binzer A. et al. Mycoplasma genitalium presence, resistance and epidemiology in Greenland. Int. J. Circumpolar. Health. 2012; 71: 1-8.
27. Guschin A., Ryzhikh P., Rumyantseva T., Gomberg M., Unemo M. Treatment efficacy, treatment failures and selection of macrolide resistance in patients with high load of Mycoplasma genitalium during treatment of male urethritis with josamycin. BMC Infect. Dis. 2015; 15: 40.
28. Приказ Минздрава России от 13.10.2017 N 804н «Об утверждении номенклатуры медицинских услуг» (Зарегистрировано в Минюсте России 07.11.2017 N 48808).
Received 07.09.2018
Accepted 21.09.2018
About the Authors
Gadzhieva, Zaida K., MD, urologist at the UKB №2 I.M. Sechenov First Moscow State Medical University (Sechenov University), Deputy Director of RSU for work with regions, RSU board member, scientific editor of Journal «Urologiia». Address: 119991, Russia, Moscow, Bolshaya Pirogovskaya street, 2c4. E-mail: zgadzhieva@ooorou.ruGomberg, Mikhail A., M.D., professor, chief researcher, Moscow Scientific and Practical Center for Dermatology, Venereology and Cosmetology, President of Guild of Specialists in STI “USTI RU”, member of Royal College
of Physicians (FRCP), American Academy of Dermatology (AAD), European Academy of Dermatology and Venereology (EADV),
Senior Counsellor of International Union against Sexually Transmitted Infections (IUSTI). Address: 119071, Russia, Moscow, Leninsky prospect, 17. E-mail: centr@mosderm.ru
Gazimiev, Magomed A., MD, Deputy Director of the Institute for Urology and Human Reproductive Health of I.M. Sechenov First Moscow State Medical University (Sechenov University), Deputy Director and Executive Director of the Russian Society of Urology (RSU), RSU board member, Deputy Editor-in-Chief of Newspaper “Vestnik ROU”. Address: 119991, Russia, Moscow, Bolshaya Pirogovskaya street, 2c4. E-mail: gazimiev@yandex.ru
Grigoryan, Vagarskak A., MD, professor, Institute for Urology and Human Reproductive Health of I.M. Sechenov First Moscow State Medical University (Sechenov University). Address: 119991, 119991, Russia, Moscow, Bolshaya Pirogovskaya street, 2c4.
Kazilov, Yusup B., MD, pediatric urologist and andrologist, Children’s Republican Clinical Hospital named after N.M. Kuraev.
Address: 367027, c. Makhachkala, Ahmed Magomedov street, 2a. E-mail: dagurolog@mail.ru
For citation: Gadzhieva Z.K., Gomberg M.A., Grigoryan V.A., Gazimiev M.A., Kazilov Yu.B. Specific features of diagnosis and treatment in pregnant women with uncomplicated urinary tract infection and urogenital infections. Akusherstvo i Ginekologiya. 2018; 11: 146-51. (in Russian)
https://dx.doi.org/10.18565/aig.2018.11.146-151