Experience of application of activated glycyrrhizic acid.in vulvovaginitis, cervicitis, and genital papillomavirus infection
Rakhmatulina M.R., Bolshenko N.V., Lipova E.V.
Objective: to evaluate the clinical efficacy of Epigen Intim, 0.1% spray, in patients with vulvovaginitis and/or cervicitis of nonspecific etiology and in those with genital papillomavirus infection (PVI).
Subjects and methods. The investigation enrolled 60 patients aged 18 to 56 years: Group 1 included 30 patients with the clinical and laboratory signs of vulvovaginitis and/or cervicitis; Group 2 comprised 30 patients with PVI and HPV values of ≥ 3 lg DNA copies per 100,000 cells. All the patients were prescribed Epigen Intim, 0.1% spray, thrice daily intravaginally; it was additionally used topically in Group 2 patients (with the clinical manifestations of PVI). The treatment cycle for Groups 1 and 2 patients was 10 and 30 days, respectively.
Results. After the treatment, there was a significant decrease in the detection rates for the subjective and objective signs of urogenital inflammatory diseases; normalization of leukocyte responses in the vagina (96.7%) and cervical canal (83.3%); reversion of the clinical manifestations of PVI (60.0%); elimination (20.0%) or a decrease in the HPV values to less than 3.0 lg HPV DNA copies per 100,000 cells (26.7%); and an improvement in the cytological examination of cervical scrapings (20.0%).
Conclusion. Epigen Intim, 0.1% spray, showed a high efficiency profile in the treatment of urogenital infections and can be recommended as an anti-inflammatory, antiviral and immunostimulating agent for the treatment of vulvovaginitis, cervicitis, and genital PVI.
Keywords
vulvovaginitis
cervicitis
papillomavirus infection
anogenital warts
human papillomaviruses
Epigen Intim
glycyrrhizic acid
References
- Годовалов А.П., Гущин М.О., Карпунина Т.И. Особенности межмикробных отношений в микробиоте влагалища инфертильных женщин. Медицинский вестник Северного Кавказа. 2019; 14(1-1): 40-4. [Godovalov A.P., Gushchin M.O., Karpunina T. I. Features of inter-microbial relations in the infertile women’s vagina microbiota. Medicinskij vestnik Severnogo Kavkaza / Medical News of North Caucasus. 2019; 14 (1.1): 40-44. (In Russian)]. https://doi.org/10.14300/mnnc.2019.14045.
- Franasiak J.M., Scott R.T. Jr. Introduction: microbiome in human reproduction. Fertil.Steril. 2015; 104(6): 1341-3. https://doi.org/10.1016/j.fertnstert.2015.10.021.
- Green K.A., Zarek S.M., Catherino W.H. Gynecologic health and disease in relation to the microbiome of the female reproductive tract. Fertil. Steril. 2015; 104(6): 1351-7. https://doi.org/10.1016/j.fertnstert.2015.10.010.
- Рахматулина М.Р., Нечаева И.А. Биопленки микроорганизмов и их роль в формировании резистентности к антибактериальным препаратам. Вестник дерматологии и венерологии. 2015; 2: 58-62. [Rakhmatulina M.R., Nechayeva I.A. Biofilms of microorganisms and their role for the formation of resistance to anti-bacterial drugs. Vestnik dermatologii i venerologii. 2015; 2: 58-62. (In Russian)]. https://doi.org/10.25208/0042-4609-2015-0-2-58-62.
- Wang B., Yao M., Lv L., Ling Z., Li L. The human microbiota in health and disease. Engineering. 2017; 3(1): 71-82. https://doi.org/10.1016/J.ENG.2017.01.008.
- Рахматулина М.Р. Терапия ассоциированных урогенитальных инфекций. Вестник дерматологии и венерологии. 2012; 4: 112-7. [Rakhmatulina M.R. Therapy of associated urogenital infections. Vestnik dermatologii i venerologii. 2012; 4: 112-117. (In Russian)].
- Роговская С.И., Ших Е.В., Рябинкина Т.С. Способ поддержания физиологического баланса вагинального биотопа. StatusPraesens. Гинекология, акушерство, бесплодный брак. 2018; 3: 60-6. [Rogovskaya S.I., Shih E.V., Ryabinkina T.S. A method of maintaining the physiological balance of the vaginal biotope. StatusPraesens. Ginekologiya, akusherstvo, besplodnyj brak. 2018; 3: 60-6. (In Russian)].
- Боровиков И.О., Куценко И.И., Кравцова Е.И., Булгакова В.П. Место активированной глицирризиновой кислоты в лечении и профилактике ВПЧ-ассоциированных поражений шейки матки. Медицинский совет. 2017; 2: 116-21. [Borovikov I.O., Kucenko I.I., Kravcova E.I., Bulgakova V.P. The place of epigen spray in the treatment and prevention HPV-associated lesions of the cervix. Medicinskij sovet. 2017; 2: 116-121. (In Russian)]. https://doi.org/10.21518/2079-701X-2017-2-116-121.
- Шуршалина А.В. Эффективное применение глицирризиновой кислоты при вирусных инфекциях половых органов. Эффективная фармакотерапия. 2009; 16: 28-33. [Shurshalina A.V. Effective using of glycyrrhizic acid in viral infections of the genital organs. Effektivnaya farmakoterapiya / Effective pharmacotherapy. 2009; 16:28–33 (in Russian)].
- Farooqui A., Khan F., Khan I., Ansari I.A. Glycyrrhizin induces reactive oxygen species-dependent apoptosis and cell cycle arrest at G0/G1 in HPV18+ human cervical cancer HeLa cell line. Biomed. Pharmacother. 2018; 97: 752-64. https://doi.org/10.1016/j.biopha.2017.10.147.
- Алиева М.Т., Шмидт А.А., Иванова Л.В., Хачатурова Н.В. Особенности заболеваемости, диагностики и терапии вируса папилломы человека среди военнослужащих-женщин – курсантов высших военных учебных заведений Министерства обороны Российской Федерации. Вестник Российской военно-медицинской академии. 2013; 4: 151-4. [Alieva M.T., Shmidt A.A., Ivanova L.V., Hachaturova N.V. Peculiarities of incidence, diagnostics and therapy of human papilloma virus among female soldiers, military students of higher military educational institutions of the Ministry of Defence of the Russian Federation. Vestnik Rossijskoj Voenno-medicinskoj akademii. 2013; 4(44): 151-154. (in Russian)].
Received 05.09.2019
Accepted 16.09.2019
About the Authors
Margarita R. Rakhmatulina, MD, professor, professor of the Department of dermatovenerology and cosmetology with a course of clinical laboratory diagnostics State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Phone: +7916 2031003. Е-mail: ra.marg@yandex.ru123098, Russia, Moscow, Zhivopisnaya str., 46.
Natalya V. Bolshenko, candidate of medical sciences, the head researcher of Federal Budget Institution of Science «Central Research Institute of Epidemiology» of The Federal Service on Customers’ Rights Protection and Human Well-being Surveillance. Dermatovenerologist of the consultative-diagnostic department Moscow Regional Clinical Dermatovenerological Center. Phone: +79164224280. E-mail: sanabol@mail.ru
111123, Russia, Moscow, Novogireevskaya str. 3a. 111123, Russia, Moscow, Schepkina str. 61/2, building 2.
Elena V. Lipova, MD, Professor, Head of the Department of dermatovenerology and cosmetology with a course of clinical laboratory diagnostics State Research
Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. Phone: +79163701504. Е-mail: elipova97@icloud.com
123098, Russia, Moscow, Zhivopisnaya str., 46.
For citation: Rakhmatulina M.R., Bolshenko N.V., Lipova E.V. Experience of application of activated glycyrrhizic acid.in vulvovaginitis, cervicitis, and genital papillomavirus infection.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 9:153-58 (In Russian).
https://dx.doi.org/10.18565/aig.2019.9.153-158
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