Oxidative stress in women with hyperproliferative diseases: non-hormonal treatment options
Krikunova L.I., Mkrtchyan L.S., Zamulaeva I.A., Yakimova A.O., Dzikovskaya L.A., Degtyareva E.S., Bespalov P.D., Salpagarova A.V., Khailova Zh.V., Ivanov S.A., Kaprin A.D.
Objective: To study the results of non-hormonal treatment for women with hyperproliferative diseases of the reproductive system and thyroid gland and to evaluate the indices of the redox system.
Materials and methods: The study included women with hyperproliferative pathology of mammary and thyroid glands, diseases of female genital organs. The women lived in the territories contaminated by radionuclides due to the Chernobyl nuclear power plant accident. This was an ultrasound assessment of the dynamics of the pathological process after taking a biologically active supplement which consisted of indole-3-carbinol 200 mg and flax lignans 200 mg (NOW Super Indole-3-carbinol with lignans). The state of the redox system before and after treatment was evaluated according to the criterion of total antioxidant activity of plasma and the content of malonic dialdehyde in blood, which is a biomarker of oxidative stress (lipid peroxidation). These parameters were compared with those of healthy individuals of similar age.
Results: The use of indole-3-carbinol complex 200 mg and flax lignans 200 mg for 60 days resulted in regression of neoplasms with an increase in BI-RADS1 (p<0.001) and TI-RADS1 (p<0.001). Non-hormonal treatment reduced malonic dialdehyde concentration from 52.2 μM/L to 44.2 μM/L median (p=0.0005) and increased total antioxidant activity from 310 μM/L to 425 μM/L median (p=0.0009). No significant differences were found with those of healthy individuals after the end of treatment (p=0.566 and p=0.230, respectively).
Conclusion: The complex of indole-3-carbinol 200 mg and flax lignans 200 mg (NOW Super indole-3-carbinol with lignans) showed effectiveness as a non-hormonal treatment of women with combined hyperproliferative pathology and normalization of redox system parameters; this may be the basis for primary prevention of malignant neoplasms.
Authors’ contributions: Kaprin A.D., Ivanov S.A., Zamulaeva I.A., Mkrtchyan L.S. – developing the concept and design of the study; Salpagarova A.V., Dzikovskaya L.A., Degtyareva E.S., Bespalov P.D. – collecting and processing the material; Mkrtchyan L.S., Zamulaeva I.A., Yakimova A.O. – statistical data processing; Mkrtchyan L.S., Zamulaeva I.A., Yakimova A.O. – writing the text; Zamulaeva I.A., Krikunova L.I., Khailova Zh.V. – editing the article.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
Patient Consent for Publication: The patients provided an informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Krikunova L.I., Mkrtchyan L.S., Zamulaeva I.A., Yakimova A.O., Dzikovskaya L.A., Degtyareva E.S., Bespalov P.D., Salpagarova A.V., Khailova Zh.V., Ivanov S.A., Kaprin A.D.
Oxidative stress in women with hyperproliferative diseases: non-hormonal treatment options.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (10): 138-146 (in Russian)
https://dx.doi.org/10.18565/aig.2024.242
Keywords
References
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Received 04.10.2024
Accepted 25.10.2024
About the Authors
Lyudmila I. Krikunova, Dr. Med. Sci., Professor, Chief Researcher, A.F. Tsyb MRSC – branch of the National Medical Research Center of Radiology, Ministry of Health of Russia, 249036, Russia, Kaluga Region, Obninsk, Korolev str., 4, krikunova_li@mail.ru, https://orcid.org/0000-0003-1842-156XLiana S. Mkrtchyan, Dr. Med. Sci., Leading Researcher, A.F. Tsyb MRSC – branch of the National Medical Research Center of Radiology, Ministry of Health of Russia,
249036, Russia, Kaluga Region, Obninsk, Korolev str., 4, +7(909)251-28-49, liana6969@mail.ru, https://orcid.org/0000-0002-5027-5331
Irina A. Zamulaeva, Dr. Bio. Sci., Professor, Head of the Department of Radiation Biochemistry, A.F. Tsyb MRSC – branch of the National Medical Research Center of Radiology, Ministry of Health of Russia, 249036, Russia, Kaluga Region, Obninsk, Korolev str., 4, zamulaeva@mail.ru, https://orcid.org/0000-0002-6136-8445
Anna O. Yakimova, PhD, Head of the Laboratory of Molecular and Cellular Radiobiology, Department of Radiation Biochemistry, A.F. Tsyb MRSC – branch of the National Medical Research Center of Radiology, Ministry of Health of Russia, 249036, Russia, Kaluga Region, Obninsk, Korolev str., 4, anna.prosovskaya@gmail.com,
https://orcid.org/0000-0002-7834-6533
Larisa A. Dzikovskaya, PhD (Bio), Senior Researcher at the Laboratory of Molecular and Cellular Radiobiology, Department of Radiation Biochemistry, A.F. Tsyb MRSC – branch of the National Medical Research Center of Radiology, Ministry of Health of Russia, 249036, Russia, Kaluga Region, Obninsk, Korolev str., 4, ldzik@yandex.ru
Elena S. Degtyareva, Researcher at the Laboratory of Molecular and Cellular Radiobiology, Department of Radiation Biochemistry, A.F. Tsyb MRSC –
branch of the National Medical Research Center of Radiology, Ministry of Health of Russia, 249036, Russia, Kaluga Region, Obninsk, Korolev str., 4, l170366@yandex.ru
Pavel D. Bespalov, PhD, Head of the Department of Ultrasound Diagnostics, A.F. Tsyb MRSC – branch of the National Medical Research Center of Radiology,
Ministry of Health of Russia, 249036, Russia, Kaluga Region, Obninsk, Korolev str., 4.
Arina V. Salpagarova, oncologist, A.F. Tsyb MRSC – branch of the National Medical Research Center of Radiology, Ministry of Health of Russia, 249036, Russia, Kaluga Region, Obninsk, Korolev str., 4, arina.rubtsova.2020@inbox.ru, https://orcid.org/0009-0000-2954-9
Zhanna V. Khailova, PhD, Deputy Director for Organizational and Methodological Work, A.F. Tsyb MRSC – branch of the National Medical Research Center of Radiology, Ministry of Health of Russia, 249036, Russia, Kaluga Region, Obninsk, Korolev str., 4, https://orcid.org/0000-0003-3258-0954
Sergey A. Ivanov, Dr. Med. Sci., Corresponding Member of the RAS, Director, A.F. Tsyb MRSC – branch of the National Medical Research Center of Radiology, Ministry of Health of Russia, 249036, Russia, Kaluga Region, Obninsk, Korolev str., 4; Professor, Department of Oncology and Radiology named after V.P. Kharchenko of Medical Institute, RUDN University, oncourolog@gmail.com, https://orcid.org/0000-0001-7689-6032
Andrey D. Kaprin, Dr. Med. Sci., Professor, Academician of the RAS, Academician of the RAE, Director, P.A. Herzen MSROI - branch of the National Medical Research Center of Radiology, Ministry of Health of Russia; CEO, National Medical Research Center of Radiology, Ministry of Health of Russia; Head of the Department of Oncology and Radiology named after V.P. Kharchenko of Medical Institute, RUDN University, kaprin@mail.ru, https://orcid.org/0000-0001-8784-8415