Possibilities of using some autoantibodies in the diagnosis of preeclampsia
Objective. To carry out a systematic analysis of the data available in the current Russian and foreign literature on a change in the level of various autoantibodies (autoAb) in the development of preeclampsia and on the possibility of its diagnostic use.Malsagova A.A., Tsakhilova S.G., Sarakhova D.Kh., Khmelnitskaya A.V., Begizova A.M., Poletaev A.B.
Material and methods. The investigations included data from the Russian and foreign publications appearing during the past 15 years.
Results. The results of clinical and immunological analyses suggest that one of the direct pathogenetic factors in the development of preeclampsia may be an abnormal decrease in the production of many autoAbs. Thus, the study of autoAbs is an additional reliable method to diagnose preeclampsia.
Conclusion. Further immunological investigations are needed to understand the significance of autoAbs in the pathogenesis of preeclampsia.
Keywords
preeclampsia
autoantibodies
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Received 21.10.2016
Accepted 11.11.2016
About the Authors
Malsagova Аngelina Ahmetovna, obstetrician-gynecologist, postgraduate student, Department of Obstetrics and Gynecology, Faculty of Dentistry, A.I. Evdokimov Moscow State University of Medicine and Dentistry. 127473, Russia, Moscow, Delegatskaya str., 20/1. Tel.: +79268261010Tsakhilova Svetlana Grigorievna, MD, Professor, obstetrician-gynecologist; branch of City Clinical Hospital #68, Moscow Healthcare Department, Maternity hospital #8. Russia, Moscow, Samarkandsky boulevard str. 3. Tel.: +79167944730
Sarahova Jamilya Hazhbarovna, PhD, associate Professor of obstetrics and gynecology, Department of Obstetrics and Gynecology, Faculty of Dentistry, A.I. Evdokimov Moscow State University of Medicine and Dentistry; obstetrician-gynecologist, branch of City Clinical Hospital #68,
Moscow Healthcare Department, Maternity hospital #8. Russia, Moscow, Samarkandsky boulevard str. 3. Tel.: +79057088466
Khmelnytskaya Antonina Vitalievna, obstetrician-gynecologist, branch of City Clinical Hospital #68, Moscow Healthcare Department,
Maternity hospital #8. Russia, Moscow, Samarkandsky boulevard str. 3. Tel.: +79251995090
Begizova Aida Mayrbekovna, PhD student, Department of Obstetrics and Gynecology, Faculty of Dentistry, A.I. Evdokimov Moscow State University of Medicine and Dentistry. 127473, Russia, Moscow, Delegatskaya str., 20/1. Tel.: +79267625200
Poletaev Alexander B., MD, Professor, immunologist, MRC “Immunculus”; Principal researcher at P.K. Anokhin Research Institute of Normal Physiology.
125009, Russia, Moscow, Mokhovaya str. 11, bld. 4. Tel.: +79250811638
For citations: Malsagova A.A., Tsakhilova S.G., Sarakhova D.Kh., Khmelnitskaya A.V., Begizova A.M., Poletaev A.B. Possibilities of using some autoantibodies in the diagnosis of preeclampsia. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (4): 27-32. (in Russian)
http://dx.doi.org/10.18565/aig.2017.4.27-32
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