New procedures for determining resection margins during organ-sparing surgery in patients with breast cancer

DOI

https://dx.doi.org/10.18565/aig.2020.6.132-140

Zikiryakhodzhaev A.D., Volchenko N.N., Reshetov I.V., Rasskazova E.A., Tregubova A.V., Khugaeva F.S.
1) P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia; 3) Peoples’ Friendship University of Russia, Moscow, Russia

Breast cancer (BC) occupies a leading place in the structure of cancers among the female population worldwide. The number of breast cancer patients currently tends to increase in the 30–45-year-old group. Organ-sparing treatment (OST) is recommended to improve quality of life in the patients. The operation involves the excision of a segment with a breast lump, but achievement of negative resection margins is mandatory. The latest data show that to achieve the purity of resection margins, indents of up to 2 mm and 1 mm are currently recommended for ductal carcinoma in situ and an invasive form, respectively. Despite the existing data on the safety and benefits of OST, 20 to 30% of patients with invasive or non-invasive BC usually undergo a reoperation. The increased number of repeated resections, and especially mastectomies, leads to severe psychological and physical traumas in women, substantially worsening the quality of life. It is important to correctly mark resection margins during surgery. The paper presents up-to-date methods to examine resection margins intraoperatively. It includes techniques, such as micro-CT, Cherenkov luminescence imaging, radiofrequency spectroscopy-based “Margin Probe”, and fluorescence imaging. The use of the most promising techniques and their long-term results are described.

breast cancer

organ-sparing treatment

intraoperative evaluation of resection margins

breast resection

micro-CT

Cherenkov luminescence imaging

radiofrequency spectroscopy-based “Margin Probe”

light microscopy

fluorescence imaging

Full text (in Russian)

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Received 26.12.2020

Accepted 07.02.2020

Aziz D. Zikiryakhodzhayev, MD, Head of the Department of Oncology and Reconstructive Surgery of the Mammary Gland and Skin; P. A. Hertsen Moscow Oncology Research Center – Branch of FSBI NMRRC of the Ministry of Health of Russia. E-mail: azizz@mail.ru.
125284, Russia, Moscow, 2-nd Botkinsky proezd, 3.
Nadezhda N. Volchenko, MD, professor, Head of the Department of oncomorphology P. A. Hertsen Moscow Oncology Research Center – Branch of FSBI NMRRC
of the Ministry of Health of Russia. E-mail:
125284, Russia, Moscow, 2-nd Botkinsky proezd, 3.
Igor V. Reshetov, Academician of the Russian Academy of Sciences, Head of the oncology, reconstructive surgery and radiology clinic of Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University). E-mail: reshetoviv@mail.ru.
119991, Russia, Moscow, Trubetskaya str., 8.
Elena A. Rasskazova, PhD, researcher of the Department of Oncology and Reconstructive Surgery of the Mammary Gland and Skin, P.Hertsen Moscow Oncology Research Institute – Branch of the National Medical Radiology Research Centre of the Ministry of Health of the Russian Federation. E-mail: rasskaz2@yandex.ru.
125284, Russia, Moscow, 2-nd Botkinsky proezd, 3.
Anna V. Tregubova, PhD student of the Department of Oncology and Reconstructive Surgery of the Mammary Gland and Skin, P.Hertsen Moscow Oncology Research Institute – Branch of the National Medical Radiology Research Centre of the Ministry of Health of the Russian Federation. E-mail: tregannavik@gmail.com.
125284, Russia, Moscow, 2-nd Botkinsky proezd, 3.
Fatima S. Khugaeva, PhD student of Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University). E-mail: hugaevaf@mail.ru. 119991, Russia, Moscow, Trubetskaya str., 8.

For reference: Zikiryakhodzhaev A.D., Volchenko N.N., Reshetov I.V., Rasskazova E.A., Tregubova A.V., Khugaeva F.S. New procedures for determining resection margins during organ-sparing surgery in patients with breast cancer.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 6: 132-140 (in Russian)
https://dx.doi.org/10.18565/aig.2020.6.132-140

New procedures for determining resection margins during organ-sparing surgery in patients with breast cancer

Zikiryakhodzhaev A.D., Volchenko N.N., Reshetov I.V., Rasskazova E.A., Tregubova A.V., Khugaeva F.S.

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