Novel coronavirus infection and pregnancy: experience of three years of the pandemic

Dyakova M.M., Bychkova S.V., Malgina G.B., Grishkina A.A., Chistiakova G.N.

Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of Russia, Yekaterinburg, Russia

The paper presents a study of scientific publications written by the Russian and foreign authors in research databases such as Pubmed, Cochrane, Web of Science, MedLine, Google Scholar, Embase, Maternity and Infant Care. It covers epidemiological aspects of coronavirus infection, experience of previous epidemics of respiratory viruses, data on the impact of novel coronavirus infection on the course of pregnancy and perinatal outcomes. At the first stages of the pandemic some publications provided the information that the SARS-CoV-2 virus is not dangerous for pregnant women. Later the incidence in pregnant women was found to be higher than in the population. The following risk factors for SARS-CoV-2 infection have been identified: concomitant pathology, late reproductive age. The clinical course of COVID-19 in pregnant women may vary from asymptomatic forms to the development of acute respiratory and multiple organ failure. Novel coronavirus infection has been proven to play a role in the development of hypertensive disorders during pregnancy, preterm birth, spontaneous miscarriage and placental pathology. To date, the available literature contains few data on the analysis of pregnancy outcomes depending on the gestational age at the time of infection. It remains unclear how coronavirus infection in pregnancy affects the development of congenital malformations in the fetus, short-term and long-term consequences for the child’s health. Conclusion: It is necessary to conduct further studies to identify the effect of the novel coronavirus infection on the course of pregnancy and perinatal outcomes. The experience obtained by the clinicians will help the society to be ready for the next challenges of the time.

Authors’ contributions: Dyakova M.M., Bychkova S.V., Grishkina A.A. – search for literary data, writing the article; Malgina G.B. – making the outline of the article, editing the article; Chistiakova G.N. – reviewing and final editing of the article.

Conflicts of interest: The authors declare no possible conflicts of interest.

Funding: The article is a review, no funding is required.

For citation: Dyakova M.M., Bychkova S.V., Malgina G.B., Grishkina A.A., Chistiakova G.N. Novel coronavirus infection and pregnancy: experience of three years of the pandemic. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (10): 5-13 (in Russian) https://dx.doi.org/10.18565/aig.2023.143

Keywords

COVID-19
SARS-CoV-2
novel coronavirus infection
pregnancy
perinatal complications
placenta
fetus
newborn
breast milk

References

  1. World Health Organization. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). February 28, 2020.
  2. Bankowski R.A., Mikami T. An apparently new respiratory disease of turkeys. Proc. Annu. Meet. U. S. Anim. Health Assoc. 1964; 68: 495-517.
  3. Tyrrell D.A., Bynoe M.L. Cultivation of a novel type of common-cold virus in organ cultures. Br. Med. J. 1965; 1(5448).: 1467-70. https://dx.doi.org/10.1136/bmj.1.5448.1467.
  4. Schwartz D.A., Graham A.L. Potential maternal and infant outcomes from (Wuhan) coronavirus 2019-nCoV infecting pregnant women: lessons from SARS, MERS, and other human coronavirus infections. Viruses. 2020; 12(2): 194. https://dx.doi.org/ 10.3390/v12020194.
  5. Львов Д.К., Альховский С.В. Истоки пандемии COVID-19: экология и генетика коронавирусов (Betacoronavirus: Coronaviridae) SARS-CoV, SARS-CoV-2 (подрод Sarbecovirus), MERS-CoV (подрод Merbecovirus). Вопросы вирусологии. 2020; 65(2): 62-70. [Lvov D.K., Alkhovsky S.V. Source of the COVID-19 pandemic: ecology and genetics of coronaviruses (Betacoronavirus: Coronaviridae) SARS-CoV, SARS-CoV-2 (subgenus Sarbecovirus), and MERS-CoV (subgenus Merbecovirus). Problems of Virology. 2020; 65(2): 62-70. (in Russian)]. https://dx.doi.org/10.36233/0507-4088-2020-65-2-62-70.
  6. Никифоров В.В., Суранова Т.Г., Чернобровкина Т.Я., Янковская Я.Д., Бурова С.В. Новая коронавирусная инфекция (COVID-19): клинико-эпидемиологические аспекты. Архив внутренней медицины. 2020; 10(2): 87-93. [Nikiforov V.V., Suranova T.G., Chernobrovkina T.Yu., Yankovskaya Y.D., Burova S.V. New Coronavirus Infection (Covid-19): Clinical and Epidemiological Aspects. The Russian Archives of Internal Medicine. 2020; 10(2): 87-93. (in Russian)]. https://dx.doi.org/10.20514/2226-6704-2020-10-2-87-93.
  7. Harris J.W. Influenza occurring in pregnant women: a statistical study of thirteen hundred and fifty cases. JAMA. 1919; April 5, 978-80. https://dx.doi.org/10.1001/jama.1919.02610140008002.
  8. Eickhoff T.C., Sherman I.L., Serfling R.E. Observations on excess mortality associated with epidemic influenza. JAMA. 1961; 176: 776-82. https://dx.doi.org/10.1001/jama.1961.03040220024005.
  9. Запольских А.М., Лыткина И.Н., Михеева И.В., Малышев Н.А., Базарова М.В., Серобян А.Г. Клинико-эпидемиологическая характеристика гриппа A(H1N1) у беременных. Эпидемиология и вакцинопрофилактика. 2014; 1(74): 66-73. [Zapolskikh A.M., Lytkina I.N., Miheeva I.V., Malyshev N.A., Bazarova M.V., Serobyan A.G. Clinical and epidemiological characteristics of influenza A(H1N1) in pregnant women. Epidemiology and Vaccinal Prevention. 2014; 1(74): 66-73. (in Russian)].
  10. Белокриницкая Т.Е., Шаповалов Т.Е., Ларёва Н.В., Пархоменко Ю.В., Лига В.Ф., Хавень Т.В., Юркова Т.С., Орлова М.В., Лапа С.Э. Интенсивная терапия беременных женщин с тяжелыми формами гриппа А/H1N1 и сезонного гриппа. Журнал акушерства и женских болезней. 2009; 18(6): 3-9. [Belokrinitskaya T.Ye., Shapovalov K.G., Laryova N.V., Parchomenko Yu.V., Liga V.F., Chaven T.V., Yurkova T.V., Orlova M.V., Lapa S.E. Principles of intensive therapy and obstetric care of the pregnants with hard forms of influenza A(H1N1) and season influenza. Journal of obstetrics and women's diseases. 2009; 18(6): 3-9. (in Russian)].
  11. Wong S.F., Chow K.M., Leung T.N., Ng W.F., Ng T.K., Shek C.C. et al. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am. J. Obstet. Gynecol. 2004; 191(1): 292-7. https://dx.doi.org/10.1016/j.ajog.2003.11.019.
  12. Ng W.F., Wong S.F., Lam A., Mak Y.F., Lee K.C., Chow K.M. et al. The placentas of patients with severe acute respiratory syndrome: a pathophysiological evaluation. Pathology. 2006; 38(3): 210-8. https://dx.doi.org/10.1080/00313020600696280.
  13. Assiri A., Abedi G.R., Al Masri M., Bin Saeed A., Gerber S.I., Watson J.T. Middle east espiratory syndrome coronavirus infection during pregnancy: A Report of 5 Cases From Saudi Arabia. Clin. Infect. Dis. 2016; 63(7): 951-3. https://dx.doi.org/10.1093/cid/ciw412.
  14. Alserehi H., Wali G., Alshukairi A., Alraddadi B. Impact of Middle East Respiratory Syndrome coronavirus (MERS‐CoV) on pregnancy and perinatal outcome. BMC Infect. Dis. 2016; 16: 105. https://dx.doi.org/10.1186/s12879-016-1437-y.
  15. Li N., Han L., Peng M., Lv Y., Ouyang Y., Liu K., Yue L. et al. Maternal and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID-19) pneumonia: a case-control study. Clin. Infect. Dis. 2020; 71(16): 2035-41. https://dx.doi.org/10.1093/cid/ciaa352.
  16. Белокриницкая Т.Е., Артымук Н.В., Филиппов О.С., Фролова Н.И. Материнские и перинатальные исходы в условиях пандемии новой коронавирусной инфекции COVID-19 в Дальневосточном и Сибирском федеральных округах. Проблемы репродукции. 2021; 27(2): 130-6. [Belokrinitskaya T.E., Artymuk N.V., Filippov O.S., Frolova N.I. Maternal and perinatal outcomes during Covid-19 pandemia in Far East and Siberian federal region of Russia. Russian Journal of Human Reproduction. 2021; 27(2): 130-6. (in Russian). https://dx.doi.org/10.17116/repro202127021130.
  17. Адамян Л.В., Вечорко В.И., Конышева О.В., Харченко Э.И. Беременность и COVID-19: актуальные вопросы (обзор литературы). Проблемы репродукции. 2021; 27(3): 70-7. [Adamyan L.V., Vechorko V.I., Konysheva O.V., Kharchenko E.I. Pregnancy and COVID-19: current issues (literature review). Russian Journal of Human Reproduction. 2021; 27(3): 70-7. (in Russian)]. https://dx.doi.org/0.17116/repro20212703170.
  18. Министерство здравоохранения Российской Федерации. Mетодические рекомендации «Организация оказания медицинской помощи беременным, роженицам, родильницам и новорожденным при новой коронавирусной инфекции COVID-19». Версия 5 (28.12.2021). [Ministry of Health of the Russian Federation. Organization of medical care for pregnant women, women in labor, women in labor and newborns with a new coronavirus infection COVID-19. Methodological guidelines. Version 5 (28.12.2021) (in Russian)].
  19. Мальгина Г.Б., Дьякова М.М., Бычкова С.В., Пепеляева Н.А., Ольков С.С., Мелкозерова О.А., Башмакова Н.В., Давыденко Н.Б. Особенности клинических проявлений легких и среднетяжелых форм новой коронавирусной инфекции у беременных в динамике эпидемического процесса. Акушерство и гинекология. 2022; 3: 23-31. [Malgina G.B., Dyakova M.M., Bychkova S.V., Pepelyaeva N.A., Olkov S.S., Melkozerova O.A., Bashmakova N.V., Davydenko N.B. Clinical manifestations of mild and moderate novel coronavirus disease in pregnant women in epidemic dynamics. Obstetrics and Gynecology. 2022; (3): 23-31. (in Russian)]. https://dx.doi.org/10.18565/aig.2022.3.23-31.
  20. Lumbers E.R., Delforce S.J., Arthurs A.L., Pringle K.G. Causes and consequences of the dysregulated maternal renin-angiotensin system in preeclampsia. Front. Endocrinol. (Lausanne). 2019; 10: 563. https://dx.doi.org/10.3389/fendo.2019.00563.
  21. Serrano B., Mendoza M., Garcia-Aguilar P., Bonacina E., Garcia-Ruiz I., Garcia-Manau P. et al. Shared risk factors for COVID-19 and preeclampsia in the first trimester: an observational study. Acta Obstet. Gynecol. Scand. 2022; 101(7): 803-8. https://dx.doi.org/10.1111/aogs.14371.
  22. da Cunha Sobieray N.L.E., Zanela M., Padilha S.L., Klas C.F., de Carvalho N.S. HELLP syndrome and COVID-19: A minor revision of a possible new "COVID-19-linked HELLP-like syndrome". Eur. J. Obstet. Gynecol. Reprod. Biol. 2023; 283: 90-4. https://dx.doi.org/10.1016/j.ejogrb.2023.02.005.
  23. Mendoza M., Garcia-Ruiz I., Maiz N., Rodo C., Garcia-Manau P., Serrano B. et al. Preeclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG. 2020; 127(11): 1374-80. https://dx.doi.org/10.1111/1471-0528.16339.
  24. Figueras F., Llurba E., Martinez-Portilla R., Mora J., Crispi F., Gratacos E. COVID-19 causing HELLP-like syndrome in pregnancy and role of angiogenic factors for differential diagnosis. medRxiv Preprint. 2020. https://dx.doi.org/10.1101/2020.07.10.20133801.
  25. Jafari M., Pormohammad A., Neshin S.A.S., Ghorbani S., Bose D., Alimohammadi S. et al. Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patient: a systematic review and meta-analysis. Rev. Med. Virol. 2021; 31(5): 1-16. https:/dx.doi.org/10.1002/rmv.2208.
  26. Martinez-Perez O., Rodriguez P.P., Muner Hernandez M., Encinas Pardilla M.B., Perez N.P., Vila Hernandez M.R. et al. The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis. BMC Pregnancy Childbirth. 2021; 2(1):273. https://dx.doi.org/10.1186/s12884-021-03742-4.
  27. Korebrits C., Ramirez M.M., Watson L., Brinkman E., Bocking A.D., Challis J.R. Maternal corticotropin-releasing hormone is increased with impending preterm birth. J. Clin. Endocrinol. Metab. 1998; 83(5): 1585-91. httrs:/dx.doiorg/10.1210/jcem.83.5.4804.
  28. Cosma S., Carosso A.R., Cusato J., Borella F., Carosso M., Bovetti M. et al. Coronavirus disease 2019 and first-trimester spontaneous abortion: a case-control study of 225 pregnant patients. Am. J. Obstet. Gynecol. 2021; 224(4): 391.e1-391.e7. httrs:/dx.doi.org/10.1016/j.ajog.2020.10.005.
  29. Fallach N., Segal Y., Agassy J., Perez G., Peretz A., Chodick G. et al. Pregnancy outcomes after SARS-CoV-2 infection by trimester: A large, population-based cohort study. PLoS One. 2022; 17(7): e0270893. https://dx.doi.org/10.1371/journal.pone.0270893.
  30. Мальгина Г.Б., Дьякова М.М., Бычкова С.В., Гришкина А.А., Пепеляева Н.А., Ольков С.С., Мелкозерова О.А., Башмакова Н.В., Давыденко Н.Б. Новая коронавирусная инфекция в I триместре беременности: перинатальные и материнские последствия. Акушерство и гинекология. 2022; 12: 90-9. [Malgina G.B., Dyakova M.M., Bychkova S.V., Grishkina A.А.,Pepelyaeva N.A., Olkov S.S., Melkozerova O.A., Bashmakova N.V., Davydenko N.B. Novel coronavirus infection inthe first trimester of pregnancy: perinatal and maternal outcomes. Obstetrics and Gynecology. 2022; (12): 90-9. (in Russian)]. https://dx.doi.org/10.18565/aig.2022.212.
  31. Balachandren N., Davies M.C., Hall J.A., Stephenson J.M., David A.L., Barrett G. et al. SARS-CoV-2 infection in the first trimester and the risk of early miscarriage: a UK population-based prospective cohort study of 3041 pregnancies conceived during the pandemic. Hum. Reprod. 2022; 37(6): 1126-33. https://dx.doi.org/10.1093/humrep/deac062.
  32. Припутневич Т.В., Гордеев А.Б., Любасовская Л.А., Шабанова Н.Е. Новый коронавирус SARS-COV-2 и беременность: обзор литературы. Акушерство и гинекология. 2020; 5: 6-12. [Priputnevich T.V., Gordeev A.B., Lyubasovskaya L.A., Shabanova N.E. The novel coronavirus SARS-CoV-2 and pregnancy: literature review. Obstetrics and Gynecology. 2020; (5): 6-12. (in Russian)]. https://dx.doi.org/10.18565/aig.2020.5.6-12.
  33. Щеголев А.И., Туманова У.Н., Серов В.Н. Поражения плаценты у беременных с SARS-CoV-2-инфекцией. Акушерство и гинекология. 2020; 12: 44-52. [Shchegolev A.I., Tumanova U.N., Serov V.N. Placental lesions in pregnant women with SARS-COV-2 infection. Obstetrics and Gynecology. 2020; (12): 44-52. (in Russian)]. https://dx.doi.org/10.18565/aig.2020.12.44-52.
  34. Щеголев А.И., Куликова Г.В., Ляпин В.М., Шмаков Р.Г., Сухих Г.Т. Выраженность синцитиальных узелков и экспрессии VEGF в ворсинах плаценты рожениц с COVID-19 зависит от степени ее тяжести. Бюллетень экспериментальной биологии и медицины. 2021; 171(3): 386-90. [Shchegolev A.I., Kulikova G.V., Lyapin V.M., Shmakov R.G., Sukhikh G.T. The severity of syncial nodules and VEGF expression in the placental villi of parturient women with COVID-19 depends on its severity. Bulletin of Experimental Biology and Medicine. 2021; 171(3): 386-90. (in Russian)].
  35. Turan O., Hakim A., Dashraath P., Jeslyn W.J.L., Wright A., Abdul-Kadir R. Clinical characteristics, prognostic factors, and maternal and neonatal outcomes of SARS-CoV-2 infection among hospitalized pregnant women: a systematic review. Int. J. Gynecol. Obstet. 2020; 151(1):7-16. https://dx.doi.org/10.1002/ijgo.13329 ijgo.13329.
  36. Мальгина Г.Б., Дьякова М.М., Бычкова С.В., Гришкина А.А., Мелкозерова О.А., Башмакова Н.В., Пепеляева Н.А., Ольков С.С. Новая коронавирусная инфекция в III триместре беременности: перинатальные и материнские последствия. Акушерство и гинекология. 2023; 4: 58-66. [Malgina G.B., Dyakova M.M., Bychkova S.V., Grishkina A.A., Melkozerova O.A., Bashmakova N.V., Pepelyaeva N.A., Olkov S.S. Novel coronavirus infection in the third trimester of pregnancy: perinatal and maternal outcomes. Obstetrics and Gynecology. 2023; (4): 58-66. (in Russian). https://dx.doi.org/10.18565/aig.2023.58.
  37. Замалеева Р.С., Черепанова Н.А., Фризина А.В., Юпатов Е.Ю. Особенности кардиотокографии плода у женщин, перенесших COVID-19 в легкой форме в третьем триместре беременности. Вопросы гинекологии, акушерства и перинатологии. 2023; 22(1): 105-10. [Zamaleeva R.S., Cherepanova N.A., Frizina A.V., Iupatov E.Yu. Characteristics of cardiotocography in pregnant women with mild COVID-19 in the third trimester. Gynecology, Obstetrics and Perinatology. 2023; 22(1): 105-10. (in Russian)]. https://dx/doi.org/10.20953/1726-1678-2023-1-105-110.
  38. Shende P., Gaikwad P., Gandhewar M., Pawankumar Ukey P., Bhide A., Patel V. et al. Persistence of SARS-CoV-2 in the first trimester placenta leading to transplacental transmission and fetal demise from an asymptomatic mother. Hum. Reprod. 2021; 36(4): 899-906. https://dx.doi.org/10.1093/humrep/deaa367.
  39. Hernández-Díaz S., Smith L.H., Wyszynski D.F., Rasmussen S.A. First trimester COVID-19 and the risk of major congenital malformations-International Registry of Coronavirus Exposure in Pregnancy. Birth Defects Res. 2022; 114(15): 906-14. https://doi.10.1002/bdr2.2070.
  40. La Cour Freiesleben N., Egerup P., Hviid K.V.R., Severinsen E.R., Kolte A.M., Westergaard D. et al. SARS-CoV-2 in first trimester pregnancy: a cohort study. Hum. Reprod. 2021; 36(1): 40-7. https://dx.doi.org/10.1093/humrep/deaa311.
  41. Di Mascio D., Sen C., Saccone G., Galindo A., Grünebaum A., Yoshimatsu J. et al. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19. J. Perinat. Med. 2020; 48(9): 950-8. https://dx.doi.org/10.1515/jpm-2020-0355.
  42. Allotey J., Chatterjee S., Kew T., Gaetano A., Stallings E., Fernández-García S. et al. SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission: living systematic review and meta-analysis. BMJ. 2022; 376: e067696. https://dx.doi.org/10.1136/bmj-2021-067696.
  43. Zaigham M., Holmberg A., Karlberg M.L., Lindsjö O.K., Jokubkiene L., Sandblom J. et al. Intrauterine vertical SARS-CoV-2 infection: a case confirming transplacental transmission followed by divergence of the viral genome. BJOG. 2021; 128(8): 1388-94. https://dx.doi.org/10.1111/1471-0528.16682.
  44. Jeganathan K., Paul A.B. Vertical transmission of SARS-CoV-2: a systematic review. Obstet. Med. 2022; 15(2): 91-8. https://dx.doi.org/10.1177/1753495X211038157.
  45. Vardhelli V., Pandita A., Pillai A., Badatya S.K. Perinatal COVID-19: review of current evidence and practical approach towards prevention and management. Eur. J Pediatr. 2021; 180(4): 1009-31. https://dx.doi.org/10.1007/s00431-020-03866-3.
  46. Neef V., Buxmann H., Rabenau H.F., Zacharowski K., Raimann F.J. Characterization of neonates born to mothers with SARS-CoV-2 infection: review and meta-analysis. Pediatr. Neonatol. 2021; 62(1): 11-20. https://dx.doi.org/10.1016/j.pedneo.2020.10.001.
  47. Villar J., Ariff S., Gunier R.B., Thiruvengadam R., Rauch S., Kholin A. et al. Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection. J. JAMA Pediatr. 2021; 175(8): 817-26. https://dx.doi.org/10.1001/jamapediatrics.2021.1050.
  48. Novoa R.H., Quintana W., Llancarí P., Urbina-Quispe K., Guevara-Ríos E., Ventura W. Maternal clinical characteristics and perinatal outcomes among pregnant women with coronavirus disease 2019. A systematic review. Travel Med. Infect. Dis. 2021; 39: 101919. https://dx.doi.org/10.1016/j.tmaid.2020.101919.
  49. Raschetti R., Vivanti A.J., Vauloup-Fellous C., Loi B., Benachi A., De Luca D. Synthesis and systematic review of reported neonatal SARS-CoV-2 infections. Nat. Commun. 2020; 11(1): 5164. https://dx.doi.org/10.1038/s41467-020-18982-9.
  50. Модель Г.Ю., Токовая И.А., Еремина О.В., Лапита А.Р. Особенности выхаживания новорожденных от матерей с новой коронавирусной инфекцией COVID-19 в условиях регионального перинатального центра. Неонатология: новости, мнения, обучение. 2022; 10(3): 8-15.
  51. [Model G.Yu., Tokovaya I.A., Eremina O.V., Lapita A.R. Features of nursing newborns from mothers with a new coronavirus infection COVID-19 in the conditions of a regional perinatal center. Neonatology: News, Opinions, Training. 2022; 10(3): 8-15. (in Russian)]. https://dx.doi.org/10.33029/2308-2402-2022-10-3-8-15.
  52. Diriba K., Awulachew E., Getu E. The effect of coronavirus infection (SARSCoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal-fetal transmission: a systematic review and meta-analysis. Eur. J. Med. Res. 2020; 25(1): 39. https://dx.doi.org/10.1186/s40001-020- 00439-w.
  53. Липатов И.С., Тезиков Ю.В., Калинкина О.Б., Тютюнник В.Л., Кан Н.Е., Майорова М.О., Яковлева М.А. Взаимосвязь новой коронавирусной инфекции с формированием задержки роста плода. Акушерство и гинекология. 2023; 2: 53-62. [Lipatov I.S., Tezikov U.V., Kalinkina O.B., Tyutyunnik V.L., Kan N.E., Majorova M.O., Yakovleva M.A. Association between new coronavirus infection and fetal growth retriction. Obstetrics and Gynecology. 2023; (2): 53-62. (in Russian)]. https://dx.doi.org/10.18565/aig.2022.260.
  54. Di Mascio D., Khalil A., Saccone G., Rizzo G., Buca D., Liberati M. et al. Outcome of coronavirus spectrum 20 infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am. J. Obstet. Gynecol. MFM. 2020; 2(2): 100107. https://dx.doi.org/10.1016/j.ajogmf.2020.100107.
  55. Badr D.A., Picone O., Bevilacqua E., Carlin A., Meli F., Sibiude J. et al. Severe acute respiratory syndrome coronavirus 2 and pregnancy outcomes according to gestational age at time of infection. Emerg. Infect. Dis. 2021; 27(10): 2535-43. https://dx.doi.org/10.3201/eid2710.211394.
  56. Narang K., Miller M., Trinidad C., Myra Wick M., Theiler R., Weaver A.L. et al. Impact of asymptomatic and mild COVID-19 infection on fetal growth during pregnancy. Eur. J. Obstet. Gynecol. Reprod. Biol. 2023; 281: 63-7. https://dx.doi.org/10.1016/j.ejogrb.2022.12.020.
  57. Ломова Н.А., Чаговец В.В., Долгополова Е.Л., Новоселова А.В., Петрова У.Л., Шмаков Р.Г., Франкевич В.Е. Изменение аминокислотного профиля в системе «мать-плод» при COVID-19. Вестник Российского государственного медицинского университета. 2022; 3: 53-63. [Lomova N.A., Chagovets V.V., Dolgopolova E.L., Novoselova A.V., Petrova U.L., Shmakov R.G., Frankevich V.E. Altered amino acid profiles of the “mother-fetus” system in COVID-19. Bulletin of RSMU. Biomedical Journal of Pirogov University (Moscow, Russia). 2022; (3): 53-63. (in Russian)]. https://dx.doi.org/10.24075/brsmu.2022.025.
  58. Shuffrey L.C., Firestein M.R., Kyle M.H., Fields A., Alcántara C., Amso D. et al. Association of birth during the COVID-19 pandemic with neurodevelopmental status at 6 months in infants with and without in utero exposure to maternal SARS-CoV-2 infection. JAMA Pediatr. 2022; 176(6): e215563. https://dx.doi.org/10.1001/jamapediatrics.2021.5563.
  59. Ayed M., Alsaffar Z., Bahzad Z., Buhamad Y., Abdulkareem A., AlQattan A. et al. Coronavirus infection in neonates: neurodevelopmental outcomes at 18 months of age. Can. J. Infect. Dis. Med. Microbiol. 2023; 2023: 6140085. https://dx.doi.org/ 10.1155/2023/6140085.
  60. Buonsenso D., Costa S., Giordano L., Priolo F., Colonna A.T., Morini S. et al. Short- and mid-term multidisciplinary outcomes of newborns exposed to SARS-CoV-2 in utero or during the perinatal period: preliminary findings. Eur. J. Pediatr. 2022; 181(4): 1507-20. https://dx.doi.org/10.1007/s00431-021-04319-1.
  61. Volpe J.J., Inder T.E., Darras B.T., de Vries L.S., du Plessis A.J., Neil J.J., Perlman J. Volpe’s Neurology of the Newborn. Elsevier Health Sciences; 2017.
  62. Bobik T.V., Kostin N.N., Skryabin G.A., Tsabai P.N., Simonova M.A., Knorre V.D. et al. Epitope-specific response of human milk immunoglobulins in COVID-19 recovered women. Pathogens. 2021; 10(6): 705. https://dx.doi10.3390/pathogens10060705.
  63. Wu Y., Liu C., Dong L., Zhang C., Chen Y., Liu J. et al. Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding. BJOG. 2020; 127(9): 1109-15. https://dx.doi.org/10.1111/1471-0528.16276.

Received 08.06.2023

Accepted 15.08.2023

About the Authors

Maria M. Dyakova, Junior Researcher, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia, +7(343)37-189-11, +7(950)550-06-52, mariadakova40@mail.ru, https://orcid.org/0000-0001-7911-6783, 620028, Russia, Yekaterinburg, Repin str., 1.
Svetlana V. Bychkova, PhD, Leading Researcher, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia, +7(343)37-189-11, simomm@mail.ru, https://orcid.org/0000-0002-8892-7785, 620028, Russia, Yekaterinburg, Repin str., 1.
Galina B. Malgina, Dr. Med. Sci., Director, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia, galinamalgina@mail.ru,
https://orcid.org/0000-0002-5500-6296, 620028, Russia, Yekaterinburg, Repin str., 1.
Anastasia A. Grishkina, PhD, Pathologist, Department of Immunology, Clinical Microbiology, Pathomorphology and Cytodiagnosis, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia, xumukyc.ru@mail.ru, https://orcid.org/0000-0001-7433-2217, 620028, Russia, Yekaterinburg, Repin str., 1.
Guzel N. Chistiakova, Dr. Med. Sci., Department of Immunology, Clinical Microbiology, Pathomorphology and Cytodiagnosis, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia, chistyakovagn@niiomm.ru, https://orcid.org/0000-0002-0852-6766, 620028, Russia, Yekaterinburg, Repin str., 1.
Corresponding authors: Maria M. Dyakova, mariadakova40@gmail.com; Svetlana V. Bychkova, simomm@mail.ru

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