Novel coronavirus infection and pregnancy: experience of three years of the pandemic

Dyakova M.M., Bychkova S.V., Malgina G.B., Grishkina A.A., Chistiakova G.N.

Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of Russia, Yekaterinburg, Russia

The paper presents a study of scientific publications written by the Russian and foreign authors in research databases such as Pubmed, Cochrane, Web of Science, MedLine, Google Scholar, Embase, Maternity and Infant Care. It covers epidemiological aspects of coronavirus infection, experience of previous epidemics of respiratory viruses, data on the impact of novel coronavirus infection on the course of pregnancy and perinatal outcomes. At the first stages of the pandemic some publications provided the information that the SARS-CoV-2 virus is not dangerous for pregnant women. Later the incidence in pregnant women was found to be higher than in the population. The following risk factors for SARS-CoV-2 infection have been identified: concomitant pathology, late reproductive age. The clinical course of COVID-19 in pregnant women may vary from asymptomatic forms to the development of acute respiratory and multiple organ failure. Novel coronavirus infection has been proven to play a role in the development of hypertensive disorders during pregnancy, preterm birth, spontaneous miscarriage and placental pathology. To date, the available literature contains few data on the analysis of pregnancy outcomes depending on the gestational age at the time of infection. It remains unclear how coronavirus infection in pregnancy affects the development of congenital malformations in the fetus, short-term and long-term consequences for the child’s health. Conclusion: It is necessary to conduct further studies to identify the effect of the novel coronavirus infection on the course of pregnancy and perinatal outcomes. The experience obtained by the clinicians will help the society to be ready for the next challenges of the time.

Authors’ contributions: Dyakova M.M., Bychkova S.V., Grishkina A.A. – search for literary data, writing the article; Malgina G.B. – making the outline of the article, editing the article; Chistiakova G.N. – reviewing and final editing of the article.

Conflicts of interest: The authors declare no possible conflicts of interest.

Funding: The article is a review, no funding is required.

For citation: Dyakova M.M., Bychkova S.V., Malgina G.B., Grishkina A.A., Chistiakova G.N. Novel coronavirus infection and pregnancy: experience of three years of the pandemic. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (10): 5-13 (in Russian)


novel coronavirus infection
perinatal complications
breast milk


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Received 08.06.2023

Accepted 15.08.2023

About the Authors

Maria M. Dyakova, Junior Researcher, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia, +7(343)37-189-11, +7(950)550-06-52,,, 620028, Russia, Yekaterinburg, Repin str., 1.
Svetlana V. Bychkova, PhD, Leading Researcher, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia, +7(343)37-189-11,,, 620028, Russia, Yekaterinburg, Repin str., 1.
Galina B. Malgina, Dr. Med. Sci., Director, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia,,, 620028, Russia, Yekaterinburg, Repin str., 1.
Anastasia A. Grishkina, PhD, Pathologist, Department of Immunology, Clinical Microbiology, Pathomorphology and Cytodiagnosis, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia,,, 620028, Russia, Yekaterinburg, Repin str., 1.
Guzel N. Chistiakova, Dr. Med. Sci., Department of Immunology, Clinical Microbiology, Pathomorphology and Cytodiagnosis, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia,,, 620028, Russia, Yekaterinburg, Repin str., 1.
Corresponding authors: Maria M. Dyakova,; Svetlana V. Bychkova,

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