Multicomponent vitamin and mineral complexes as a basis for prevention of micronutrient deficiency at reproductive age

Shikh E.V., Makhova A.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia
Micronutrient supplementation is a key factor for physiological pregnancy and directly correlates with positive maternal outcomes, has a direct impact on neonatal health and subsequent development. A relationship was found between the insufficient supply of mothers with nutrients and preeclampsia, fetal growth restriction, neural tube defects, skeletal deformities, and low birth weight. Multicomponent vitamin and mineral complexes intended to use in the pregravid period, during pregnancy, and lactation allow the entry of essential micronutrients, such as iron, folates and other B vitamins, iodine, zinc, and antioxidants, into the body at the physiological daily requirements. This review presents current evidence regarding the needs for macronutrients and micronutrients during pregnancy, the risks and consequences of their deficiency, and the impact of additional exogenous intake on pregnancy outcomes.


vitamin and mineral complexes
pregnancy outcomes


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Received 25.11.2019

Accepted 29.11.2019

About the Authors

Evgenia V. Shikh, MD, professor, head Department of Clinical Pharmacology and Propaedeutics of Internal Diseases FGAOU VO First MGMU im. I. M. Sechenov
of the Ministry of Health of Russia (Sechenov University). Tel .: +7 (495)609-19-91. E-mail:;
Address: 119991, Russia, Moscow, ul. Trubetskaya, d. 8, p. 2.
Anna A. Makhova, MD, associate professor of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases FSAEI HE First MGMU named after I.M.Sechenova of the Ministry of Health of Russia (Sechenov University). Phone: +7(495) 609-19-91. Email:;
Address: 119991, Russia, Moscow, ul. Trubetskaya, d. 8, p. 2.

For citation: Shikh E.V., Makhova A.A. Multicomponent vitamin and mineral complexes as a basis for prevention of micronutrient deficiency at reproductive age.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 1: 54-62. (In Russian).

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