MicroRNA regulation in the genesis of fetal growth restriction
MicroRNA is a class of short non-coding RNAs that carry out epigenetic regulation of many biological processes, including the course of pregnancy. More than 500 microRNAs associated with the formation and functioning of the placenta are presently known. The expression level of these microRNAs may be an indicator of placental changes during pregnancy. A number of placenta-specific microRNAs detected in maternal plasma can be regarded as potential non-invasive markers of maternal and fetal health. The data available in the modern scientific literature on changes in the expression of placenta-specific microRNAs circulating in the plasma of a pregnant woman with fetal growth restriction are analyzed. MicroRNAs can play an important, but currently not fully investigated role in the initiation of gestational complications. The use of microRNAs in the prediction and treatment of diseases and pregnancy complications is a promising area that requires further investigation.Zabanova E.A., Kuznetsova N.B., Skurat T.P., Butenko E.V.
Keywords
microRNA
fetal growth restriction
placenta
pregnancy complications
preeclampsia
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Received 16.04.2019
Accepted 19.04.2019
About the Authors
Ekaterina A. Zabanova, Postgraduate at the Department of Simulation education of RostSMU.344022, 29 Nahichevansky ave., Rostov-on-Don, Russian Federation. Phone: +7(918)566-88-25, e-mail:rock-fe@mail.ru.
Natalia B. Kuznetsova, Doctor of Medical Sciences, Professor at the Department of Simulation education of RostSMU.
344022, 29 Nahichevansky ave., Rostov-on-Don, Russian Federation. Phone: +7(928)770-97-62, e-mail:lauranb@inbox.ru .
Tatiana P. Shkurat., Doctor of Biological Sciences, Full Professor, Director of Research Institute of Biology of SFedU.
344090, 194/1 Stachki ave., Rostov-on-Don, Russian Federation. Phone: +7(863)243-38-85, e-mail:tshkurat@sfedu.ru .
Elena V. Butenko, Candidate of Biological Sciences, Associate Professor at the Department of genetics of Academy of Biology and Biotechnologies of SFedU.
344090, 194/1 Stachki ave., Rostov-on-Don, Russian Federation. Phone: +7(909)420-22-23, e-mail:evbutenko@sfedu.ru
For citation: Zabanova E.A., Kuznetsova N.B., Skurat T.P., Butenko E.V. MicroRNA regulation in the genesis of fetal growth restriction.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 12: 5-11. (In Russian).
https://dx.doi.org/10.18565/aig.2019.12.5-11