Menopausal osteoporosis and vitamin D

Kuznetsova I.V.

I.M. Sechenov First Moscow State Medical University, Russia
The author has carried out a systems analysis of the data available in the current literature on the participation of vitamin D in the physiology of bone metabolism, the pathogenesis of osteoporosis, and the possibilities of osteoporosis therapy with active vitamin D metabolites. The paper describes the mechanisms of vitamin D participation in the processes of bone metabolism and calcium homeostasis. It presents the effects of vitamin D on connective and muscle tissues. Its deficiency is shown to play a role in the pathogenesis of osteoporosis and in the increased risk of low-trauma fractures. There are clinical trial findings that confirm the possibility of using active vitamin D metabolites for the therapy of osteoporosis and for the prevention of low-trauma fractures. Active vitamin D metabolites used alone or in combination with antiresorptive therapy for osteoporosis is an effective measure to prevent low-trauma fractures and can be prescribed for menopausal osteoporosis.

Keywords

osteoporosis
menopausal osteoporosis
osteoporotic fractures
osteoporosis therapy
fall prevention
vitamin D
active vitamin D metabolites
alfacalcidol

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Received 08.06.2018

Accepted 22.06.2018

About the Authors

Kuznetsova, Irina V., MD, Professor of the Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University.
Tel.: +74992487414. E-mail: ms.smith.ivk@gmail. com

For citations: Kuznetsova I.V. Menopausal osteoporosis and vitamin D. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (8): 41-7. (in Russian)
https://dx.doi.org/10.18565/aig.2018.8.41-47

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