The role of genistein and melatonin in the correction of vasomotor symptoms, sleep disorders and the prevention of osteoporosis during perimenopause

Solovyeva A.V., Kuznetsova O.A., Smirnova T.V.

Department of Obstetrics and Gynecology with Course of Perinatology, Medical Institute, Peoples’ Friendship University of Russia, Ministry of Education and Science of the Russian Federation, Moscow
To analyze the data available in the literature on the problem of correcting vasomotor symptoms and sleep disorders with genistein- and melatonin-containing complexes during the menopausal transition, foreign and Russian works published in the past two decades were sought in the international citation system PubMed. The mutual influence of menopausal symptoms and sleep disorders was found in menopausal women; the data from studies of the efficiency of therapy aimed at improving sleep quality and reducing menopausal symptoms with the drugs containing melatonin and phytoestrogens were systematized. It was noted that it was expedient to co-use alternatives for restoring sleep and reducing menopausal vasomotor symptoms, vitamin D in combination with calcium in order to prevent osteoporosis.

Keywords

menopause
sleep disorders
vasomotor symptoms
melatonin
soy isoflavones
vitamin D
calcium carbonate

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Received 19.06.2019

Accepted 21.06.2019

About the Authors

Solovyeva Alina V., MD, associate Professor of the obstetrics and gynecology department with a course in perinatology, Peoples’ Friendship University of Russia, Moscow.
117198, Russia, Moscow, Miklukho-Maklaya str.,8. Tel :+79854477928, e-mail: av_soloveva@mail.ru
Kuznetsova Olga A., PhD , associate Professor of the obstetrics and gynecology department with a course in perinatology, Peoples’ Friendship University of Russia, Moscow.
117198, Russia, Moscow,Miklukho-Maklaya str.,8. E-mail: koa.15@mail.ru. Tel +79161237918.
Smirnova Tatyana V., PhD , associate Professor of the obstetrics and gynecology department with a course in perinatology, Peoples’ Friendship University of Russia, Moscow.
117198, Russia, Moscow, Miklukho-Maklaya str.,8. E-mail: koa.15@mail.ru. Tel+79163208758/

For citations: Solovyeva A.V., Kuznetsova O.A., Smirnova T.V. The role of genistein and melatonin in the correction of vasomotor symptoms, sleep disorders and the prevention of osteoporosis during perimenopause. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (7): 118-22 (in Russian).
http://dx.doi.org/10.18565/aig.2019.7.118-122

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