Correction of climacteric disorders in patients with breast cancer: current methods and prospects

Smetnik A.A., Rodionov V.V., Kometova V.V.

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia, Moscow
Treatment of menopausal syndrome in patients with breast cancer is aimed not only at maintaining the quality of life, but also at increasing life expectancy, including by reducing refusal rates of anti-recurrence therapy. The most effective treatment option is menopausal hormone therapy, which, with some exceptions, is contraindicated in patients with breast cancer. Phytoestrogens and serotonin-norepinephrine reuptake inhibitors are an alternative to relieve vasomotor symptoms. If non-hormonal treatment of genitourinary menopausal syndrome has no effect, estrogens should be considered for vaginal treatment. Promising treatment modalities include a tissue-selective estrogen complex, estetrol, ospemifene and vaginal dehydroepiandrosterone. Loss of bone mineral density and fractures in breast cancer patients has many causes. Effective treatments include bisphosphonates and denosumab.

Keywords

menopausal syndrome
breast cancer
genitourinary menopausal syndrome
vulvovaginal atrophy
osteoporosis
menopausal hormone therapy
phytoestrogens
antidepressants

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Received 27.12.2019

Accepted 30.12.2019

About the Authors

Antonina A. Smetnik, PhD, Senior Researcher, Department of Gynecological Endocrinology, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.. Tel.: +74955314444, ext. 1543. E-mail: a_smetnik@oparina4.ru
117997, Russia, Moscow, Ac. Oparina str. 4
Valeriy V. Rodionov, MD, Head of the Department of Breast Pathology, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
Tel.: +79265626590. E-mail: V_Rodionov@oparina4.ru
117997, Russia, Moscow, Ac. Oparina str. 4.
Vlada V. Kometova, MD, Senior Researcher of Department of Pathological Anatomy, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. Tel.: +79265626590. E-mail: v_kometova@oparina4.ru
117997, Russia, Moscow, Ac. Oparina str. 4.

For citation: Smetnik A.A., Rodionov V.V., Kometova V.V. Correction of climacteric disorders in patients with breast cancer: current methods and prospects.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 1(Suppl): 26-33. (in Russian)
https://dx.doi.org/10.18565/aig.2020.1suppl.26-33

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