Lipidomic markers and prospects for their use in human papillomavirus-associated cervical diseases

1. Stewart B.W., Wild C.P., eds. World Cancer Report 2014. Geneva, Switzerland: IARC, WHO Press; 2015.
2. Ашрафян Л.А., Оводенко Д.Л. Основные трудности скрининга рака шейки матки. Акушерство и гинекология: новости, мнения, обучение. 2018; 1: 14-7. [Ashrafyan L.A., Ovodenko D.L. Сervical cancer screening key problems. Obstetrics and Gynecology: News, Opinions, Training. 2018; (1): 14-17. (in Russian)] https://cyberleninka.ru/article/n/osnovnye-trudnosti-skrininga-raka-sheyki-matki
3. Jing L., Dan W., Zhunan L., Ying X.., Yi C. Residual lesions in uterine specimens after loop electrosurgical excision procedure in patients with CIN. Arch. Gynecol. Obstet. 2018; 298(4): 805-12. https://doi.org/10.1007/s00404-018-4881-7.
4. El-Nashar S.A., Shazly S.A., Hopkins M.R., Bakkum-Gamez J.N., Famuyide A.O. Loop electrosurgical excision procedure instead of cold-knife conization for cervical intraepithelial neoplasia in women with unsatisfactory colposcopic examinations: a systematic review and meta-analysis. J. Low. Genit. Tract. Dis. 2017; 21(2): 129-36. https://doi.org/10.1097/LGT.0000000000000287.
5. Jiang Y., Chen C., Li L. Comparison of cold-knife conization versus loop electrosurgical excision for cervical adenocarcinoma in situ (ACIS): a systematic review and meta-analysis. PLoS One. 2017; 12(1): e0170587. https://doi.org/10.1371/journal.pone.0170587.
6. Wang X.I., Huang F., Zhang S. Loop electrosurgical excision procedure vs. cold Knife cone in treatment of cervical intraepithelial neoplasia: review of 447 cases. Ann. Clin. Lab. Sci. 2017; 47(6): 663-7.
7. Liu L., Chen L.M., Tao X., Dai F., Guo L.P., Zhang H.W. et al. Clinical outcome and high risk factor for residual lesion analysis of HSIL half a year after loop electrosurgical excision procedure: a clinical study of 1 502 cases. Zhonghua Fu Chan Ke Za Zhi. 2017; 52(11): 751-6. https://doi.org/10:3760/cma.j.issn.0529-567X.2017.11.007.
8. Wu J., Jia Y., Luo M., Duan Z. Analysis of residual/recurrent disease and its risk factors after loop electrosurgical excision procedure for high-grade cervical intraepithelial neoplasia. Gynecol. Obstet. Invest. 2016; 81(4): 296-301. https://doi.org/10.1159/000437423.
9. Rositch A.F., Soeters H.M., Offutt-Powell T.N., Wheeler B.S., Taylor S.M., Smith J.S. The incidence of human papillomavirus infection following treatment for cervical neoplasia: a systematic review. Gynecol. Oncol. 2014; 132(3): 767-79. https://doi.org/10.1016/j.ygyno.2013.12.040.
10. Tanaka Y., Ueda Y., Kakuda M., Kubota S., Matsuzaki S., Iwamiya T. et al. Predictors for recurrent/persistent high-grade intraepithelial lesions and cervical stenosis after therapeutic conization: a retrospective analysis of 522 cases. Int. J. Clin. Oncol. 2017; 22(5): 921-6. https://doi.org/10.1007/s10147-017-1124-z.
11. Ciavattini A., Clemente N., Delli Carpini G., Gentili C., Di Giuseppe J., Barbadoro P. et al. Loop electrosurgical excision procedure and risk of miscarriage. Fertil. Steril. 2015; 103(4): 1043-8. https://doi.org/10.1016/j.fertnstert.2014.12.112.
12. Kitson S.J., Greig E., Michael E., Smith M. Predictive value of volume of cervical tissue removed during LLETZ on subsequent pretermdelivery: a cohort study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2014; 180: 51-5. https://doi.org/10.1016/j.ejogrb.2014.06.011.
13. Liverani C.A., Di Giuseppe J., Clemente N., Delli Carpini G., Monti E.., Fanetti F. et al. Length but not transverse diameter of the excision specimen for high-grade cervical intraepithelial neoplasia (CIN 2-3) is a predictor of pregnancy outcome. Eur. J. Cancer Prev. 2016; 25(5): 416-22. https://doi.org/10.1097/CEJ.0000000000000196.
14. Berretta R., Gizzo S., Dall’Asta A., Mazzone E., Monica M., Franchi L. et al. Risk of preterm delivery associated with prior treatment of cervical precancerous lesion according to the depth of the cone. Dis Markers. 2013; 35(6): 721-6. https://doi.org/10.1155/2013/686027.
15. Некрасова М.Е., Стародубцева Н.Л., Чаговец В.В., Назарова Н.М., Кононихин А.С., Франкевич В.Е. Липидомика: новые перспективы поиска маркеров неоплазий. Акушерство и гинекология. 2017; 3: 34-40. [Nekrasova M.E., Nazarova N.M., Starodubtseva N.L., Chagovets V.V., Kononikhin A.S., Frankevich V.E., Prilepskaya V.N. Lipidomics: New perspectives on search for markers of neoplasia. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (3): 34-40. (in Russian)]. https://dx.doi.org/10.18565/aig.2017.3.34-40
16. Стародубцева Н.Л., Назарова Н.М., Зардиашвили М.Д., Бурменская О.В., Бугрова А.Е., Чаговец В.В., Кононихин А.С., Трофимов Д.Ю., Франкевич В.Е., Сухих Г.Т. Комбинация протеомного и транскриптомного подходов для определения риска малигнизации неоплазий шейки матки при папилломавирусной инфекции. Акушерство и гинекология. 2017; 5: 64-71.[Starodubtseva N.L., Nazarova N.M., Zardiashvili M.D., Bourmenskaya O.V., Bugrova A.E., Chagovets V.V., Kononikhin A.S., Trofimov D.Y., Frankevich V.E., Sukhikh G.T. Predicting the risk of cervical intraepithelial neoplasia associated with HPV infection malignisation using the combination of proteomics and transcriptomics. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (5): 64-71. (in Russian)]. https://dx.doi.org/10.18565/aig.2017.5.64-71.
17. Adamyan L., Starodubtseva N., Borisova A., Stepanian S., Chagovets V., Salimova D., Zhihao Wang, Kononikhin A., Popov I., Bugrova A., Chingin K., Kozachenko K., Chen H., Frankevich V. Direct mass spectrometry differentiation of ectopic and eutopic endometrium in patients with endometriosis. J. Minim. Invasive Gynecol. 2018, 25(3): 426-33.
18. Chagovets V., Zhihao Wang, Kononikhin A., Starodubtseva N., Borisova A., Salimova D., Popov I., Kozachenko A., Chingin K., Chen H., Frankevich V., Adamyan L., Sukhikh G. A comparison of tissue spray and lipid extract direct injection electrospray ionization mass spectrometry for the differentiation of eutopic and ectopic endometrial tissues. J. Am. Soc. Mass Spectrom. 2018; 29(2): 323-30.
19. Борисова А.В., Стародубцева Н.Л., Козаченко А.В., Чаговец В.В., Салимова Д.Ф., Кононихин А.С., Адамян Л.В., Франкевич В.Е., Сухих Г.Т. Исследование эутопического и эктопического эндометрия различной локализации методом прямой масс-спектрометрии. Акушерство и гинекология. 2016; 9: 101-8. [Borisova A.V., Starodubtseva N.L., Kozachenko A.V., Chagovets V.V., Salimova D.F., Kononikhin A.S., Kogan E.A., Adamyan L.V., Frankevich V.E., Sukhikh G.T. Direct mass spectrometry investigation of endometriotic foci at various sites. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2016; (9): 101-8. (in Russian)]. https://dx.doi.org/10.18565/aig.2016.9.101-8.
20. Chagovets V.V., Wang Z., Kononikhin A.S., Starodubtseva N.L., Borisova A., Salimova D., Popov I.A., Kozachenko A.V., Chingin K., Chen H., Frankevich V.E., Adamyan L.V., Sukhikh G.T. Endometriosis foci differentiation by rapid lipid profiling using tissue spray ionization and high resolution mass spectrometry. Sci. Rep. 2017; 7(1): 2546. https://doi.org/10.1038/s41598-017-02708-x.
21. Pietrowska M., Marczak L., Polanska J., Behrendt K., Nowicka E., Walaszczyk A. et al. Mass spectrometry-based serum proteome pattern analysis in molecular diagnostics of early stage breast cancer. J. Transl. Med. 2009; 7: 60. https://doi.org/10.1186/1479-5876-7-60.
22. Kang S., Lee A., Park Y.S., Lee S.C., Park S.Y., Han S.Y. et al. Alteration in lipid and protein profiles of ovarian cancer similarity to breast cancer. Int. J. Gynecol. Cancer. 2011; 21(9): 1566-72. https://doi.org/10.1097/IGC.0b013e318226c5f5.
23. Moro K., Kawaguchi T., Tsuchida J., Gabriel E., Qi Q., Yan L. et al. Ceramide species are elevated in human breast cancer and are associated with less aggressiveness. Oncotarget. 2018; 9(28): 19874-90. https://doi.org/10.18632 /oncotarget.24903.
24. Porcari A.M., Negrao F., Tripodi G.L., Pitta D.R. Molecular signatures of high cervical lesions. Front. Oncol. 2018; 8: 99. https://doi.org/10.3389/fonc.2018.00099.
25. Qiu F., Chen F., Liu D., Xu J., Xiao J., Cao L., Huang X. LS-MS/MS-based screening of new protein biomarkers for cervical precancerous lesions and cervical cancer. Nan Fang Yi Ke Da Xue Xue Bao (Journal of Southern Medical University). 2019; 39(1): 13-22. https://doi.org/10.12122/j.issn.1673-4254.2019.01.03.

Received 30.04.2019

Accepted 21.06.2019