Use of probiotics during antimicrobial pharmacotherapy: clinical and pharmacological aspects
Objective. To carry out a systematic analysis of the data available in the literature on rational therapy for vaginal microbiocenotic disorders during combined antibacterial therapy to optimize the use of probiotics.Shikh E.V., Rebrova E.V., Knyazeva S.A., Ignatova L.M.
Material and methods. The review includes the data of foreign and Russian articles found in the international system Pubmed.
Results. The polymicrobial etiology of the inflammatory process requires combined antibacterial therapy using 2–3 antibiotics, which predisposes to dysbiotic states and the growth of opportunistic pathogens, including Candida fungi. It is advisable to prophylactically take probiotics simultaneously with the initiation of antibiotic therapy, which is more effective than the use of probiotics immediately after completion of an antibiotic therapy cycle. The vagina can be colonized by probiotic bacteria following oral administration if acid-resistant strains of lactobacilli are used.
Conclusion. It is expedient to simultaneously take acid-resistant probiotic strains per os during antibiotic therapy in order to restore a normal protective flora and to suppress the opportunistic intestinal microorganisms that are able to colonize the urogenital area.
Keywords
dysbiosis
antimicrobial therapy
probiotics
inflammatory diseases
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Received 08.12.2017
Accepted 22.12.2017
About the Authors
Shih Evgenia Valeryevna, MD, professor, head of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, I.M. SechenovFirst Moscow State Medical University, Ministry of Health of Russia. 119991, Russia, Moscow, Bolshaya Pirogovskaya str. 2, bld. 4. E-mail: chih@mail.ru
Rebrova Ekaterina Vladislavovna, Ph.D., Associate Professor of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, I.M. Sechenov
First Moscow State Medical University, Ministry of Health of Russia. 119991, Russia, Moscow, Bolshaya Pirogovskaya str. 2, bld. 4. E-mail: katrina1987@rambler.ru
Knyazeva Svetlana, Ph.D., Associate Professor of the Department of Medical and Social Examination, Urgent and Polyclinic Therapy, I.M. Sechenov First Moscow
State Medical University, Ministry of Health of Russia. 119991, Russia, Moscow, Bolshaya Pirogovskaya str. 2, bld. 4. E-mail: svknyazeva@mail.ru
Ignatova Lyudmila, a fifth-year student of the Faculty of Dentistry, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia.
119991, Russia, Moscow, Bolshaya Pirogovskaya str. 2, bld. 4. E-mail: miley.96@mail.ru
For citations: Shikh E.V., Rebrova E.V., Knyazeva S.A., Ignatova L.M. Use of probiotics during antimicrobial pharmacotherapy: clinical and pharmacological aspects. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (3): 30-6. (in Russian)
https://dx.doi.org/10.18565/aig.2018.3.30-36
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