Clinical and diagnostic significance of genetic predisposition to preeclampsia in the Kazakh population

Mirzakhmetova D.D., Svyatova G.S., Berezina G.M., Murtazaliyeva A.V.

Research Center of Obstetrics, Gynecology, and Perinatology, Almaty, Kazakhstan
Objective. To study the relationship of Factor V (FV) (rs6025), FII (rs1799963), MTHFR (rs1801133, rs1801131), MTRR (rs1801394), MTR (rs1805087), eNOS3 (rs1799983), ACE (rs4340), AGTR1 (rs5186), and ApoS3 (rs5128) polymorphisms to the development of preeclampsia in the homogeneous ethnic Kazakh population. Subjects and methods. Independent replicative TaqMan genotyping was carried out in 205 pregnant and puerperal women with preeclampsia and 300 pregnant and puerperal women with uncomplicated pregnancy. Results. The performed study revealed a statistically significant association (p <0.002) of the studied SNPs with the development of preeclampsia in the Kazakh population according to the folate metabolism genes: MTHFR (A1298C) and MTR (A2756G); the coagulation system gene: FII (G20210A); the aldosterone-renin-angiotensin system genes: AGTR1 (A1166C), eNOS3 (Glu298Asp), and ACE (I/D); the lipid metabolism gene: ApoC3 (G5163C). Conclusion. The found associated gene polymorphisms can be regarded as possible genetic factors for preeclampsia in the Kazakh population.

Keywords

gene polymorphism
genotypes
preeclampsia

References

  1. Steegers E.A., Duvekot J.J., Pijnenborg R. Pre-eclampsia. Lancet. 2010; 376(9741): 631–44. doi: 10,.1016/S0140-6736(10)60279-6).
  2. Uzan J., Carbonnel M., Piconne O., Asmar R., Ayoubi J.M. Pre-eclampsia: pathophysiology, diagnosis, and management. Vasc Health Risk Manag. 2011; 7: 467–74. doi: 10,2147/VHRM,S20181.
  3. Duley L. The global impact of pre-eclampsia and eclampsia, Semin Perinatol. 2009; 33(3):130–7. doi: 10,1053/j,semperi.2009.02.010
  4. Veropotveljan P.N., Veropotveljan N.P., Smorodskaja E.P., Lazarenko A.T. Modern view on the problem of pre-eclampsia. Zdorov’e Ukrainy. 2011; 6(46): 43–52. (Link: https://mazg,com,ua/ru-issue-article-470)
  5. Zhao L., Bracken M.B., DeWan A.T. Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort. Ann Hum Genet. 2013; 77(4): 277-87. doi: 10,1111/ahg,12021
  6. Johnson M.P., Brennecke S.P., East C.E., et al, Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene. PLoS One. 2012; 7(3): e33666. doi: 10.1371/journal.pone.0033666
  7. Alkanli N., Sipahi T., Kilic T.O., Sener S. Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region. J Obstet Gynecol. 2014; 2(4): 49–53. doi: 10.11648/j.jgo.20140204.11
  8. Elfadil G.A., Wagea A.D.I, Elmugadam A.A. Association of Angiotensinogen M235T Gene variants, and Plasma Renin Activity with Preeclampsia. Egypt Acad J Biolog Sci. 2014; 6(1): 141–9. (Link: https://www,researchgate,net/publication/265415351_Association_of_Angiotensinogen_M235T_Gene_variants_and_Plasma_Renin_Activity_with_Preeclampsia)
  9. Escudero C., Roberts J.M., Myatt L., Feoktistov I. Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming. Front Pharmacol. 2014; 5(134): 1–13. doi:10.3389/fphar.2014.00134
  10. Wang X., Bai T., Liu S., Pan H., Wang B. Association between thrombophilia gene polymorphisms and preeclampsia: a meta-analysis. PLoS One. 2014; 9(6): e100789. doi:10.1371/journal.pone.0100789
  11. Buurma A.J., Turner R.J., Driessen J.H., Mooyaart A.L., Schoones J.W., Bruijn J.A., et al. Genetic variants in pre-eclampsia: a meta-analysis. Hum Reprod Update. 2013; 19(3): 289–303. doi: 10,1093/humupd/dms060
  12. Vitoratos N., Vrachnis N.., Iavazzo C., Kyrgiou M. Preeclampsia: molecular mechanisms, predisposition, and treatment. J Pregnancy. 2012; 2012:1–2. doi: 10.1155/2012/145487
  13. Sandrim V., Palei A., Sertorio J., Cavalli R., Duarte G., Tanus-Santos J. Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia. Mol Hum Reprod. 2010; 16(7): 506–10. doi: 10.1093/molehr/gaq030
  14. Singh A., Sharma D., Raghunandan C., Bhattacharjee J. Role of inflammatory cytokines and eNOS gene polymorphism in pathophysiology of pre-eclampsia. Am J Reprod Immunol. 2010; 63(3): 244–51. doi: 10.1111/j.1600-0897.2009.00781.x
  15. Baranov V.S. Genetic passport is fundamental for personalised and predictive medicine. Saint Petersburg: «N-L», 2009. 527 p. https://medinfo,social/uchebniki _884/geneticheskiy-pasport-osnova-individualnoy,html
  16. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007; 81(3): 559–75. doi: 10.1086/519795
  17. Haram K., Mortensen J.H., Nagy B. Genetic aspects of preeclampsia and the HELLP syndrome. J Pregnancy. 2014; 2014: 910751. doi: 10.1155/2014/910751
  18. Williams P., Broughton Pipkin F. The genetics of pre-eclampsia and other hypertensive disorders of pregnanc. Best Pract Res Clin Obstet Gynaecol. 2011; 25(4): 405–17. doi: 10,1016/j.bpobgyn.2011.02,007
  19. Williams P.J., Morgan L. The role of genetics in pre-eclampsia and potential pharmacogenomic interventions. Pharmgenomics Pers Med. 2012; 5: 37–51. doi: 10.2147/PGPM.S23141
  20. Petla L.T., Chikkala R., Ratnakar K.S., Kodati V., Sritharan V. Biomarkers for the management of pre-eclampsia in pregnant women. Indian J Med Res. 2013; 138(1): 60–7. PMID: 24056556
  21. Pennington K.A., Schlitt J.M., Jackson D.L., Schulz L.C., Schust D.J. Preeclampsia: multiple approaches for a multifactorial disease. Dis Model Mech. 2012; 5(1): 9–18. doi: 10.1242/dmm,008516.
  22. Szabo S., Xu Y., Romero R., Fule T., Karaszi K., Bhatti G., et al. Changes of placental syndecan-1 expression in preeclampsia and HELLP syndrome. Virchows Arch. 2013; 463(3): 445–58. doi: 10,1007/s00428-013-1426-0

Received 04.11.2019

Accepted 29.11.2019

About the Authors

Dinara D. Mirzakhmetova, Acting Chair of Board Joint-Stock Company Scientific Center of Obstetrics, Gynecology and Perinatology. Phone: +7 (727)300-45-46.
E-mail: d.mirzakhmetova@mail.ru; ORCID ID 0000-0002-6329-5999.
A25D6G4 Kazakhstan, Almaty, 125 Dostyk Ave.
Gulnara S. Svyatova, Doctor of Medicine, Professor, Head of the Republican Medical Genetic Consultation of Scientific Center of Joint-Stock Company “Scientific Center
of Obstetrics, Gynecology and Perinatology”, ORCID ID 0000-0001-5092-3143; Phone: +7 (727) 300-45-61. E-mail: gsvyatova1@mail.ru
A25D6G4 Kazakhstan, Almaty, 125 Dostyk Ave.
Galina M. Berezina, Doctor of Biological Sciences, Associate Professor, Specialist of the Laboratory in Republican Medical Genetic Consultation of Joint-Stock Company Scientific Center of Obstetrics, Gynecology and Perinatology. Phone: +7 (727)300-45-62. E-mail: gberezina54@mail.ru; ORCID ID 0000-0002-5442-4461.
A25D6G4 Kazakhstan, Almaty, 125 Dostyk Ave.
Alexandra V. Murtazaliyeva, genetic counselor in Republican Medical Genetic Consultation of Joint-Stock Company Scientific Center of Obstetrics, Gynecology and Perinatology. ORCID ID 0000-0001-9156-5944. phone: +7 (727)300-45-62. E-mail: alexmurtazalieva@gmail.com
A25D6G4 Kazakhstan, Almaty, 125 Dostyk Ave.

For citation: Mirzakhmetova D.D., Svyatova G.S., Berezina G.M., Murtazaliyeva A.V. Clinical and diagnostic significance of genetic predisposition to preeclampsia in the Kazakh population.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 3: 58-63. (In Russian).
https://dx.doi.org/10.18565/aig.2020.3. 58-63

Similar Articles

By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.