On the pathogenesis of reproductive disorders in women with obesity
Objective. To carry out a systematic analysis of the data available in the current literature on the role of adipokines in reproductive dysfunction in obese women.Vedzizheva E.R., Kuznetsova I.V., Uspenskaya Yu.B., Gitel E.P., Vasilyeva I.V.
Material and methods. For analysis, foreign and Russian works published in the past 15 years were sought for in the international citation system Pubmed.
Results. The modern theories of the mechanism of reproductive disorders in obese women were described; the key factors of impact of adipose tissue on fertility were described. The importance of regulation of the body’s metabolic processes in restoring fertility and preparing women for pregnancy was highlighted.
Conclusion. Most current studies often show conflicting and ambiguous results, which leads to the need for further research.
Keywords
adipose tissue
overweight
obesity
female reproductive health
adipokines
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Received 12.12.2016
Accepted 23.12.2016
About the Authors
Vedzizheva Elina Ruslanovna, graduate student at Research Department of Women’s Health, I.M. Sechenov First Moscow State Medical University,Ministry of Health of Russia. 119991, Russia, Moscow, Bolshaya Pirogovskaya str. 2, bld. 4. E-mail: ishu2009@mail.ru
Kuznetsova Irina Vsevolodovna, MD, professor, chief researcher at Research Department of Women’s Health, I.M. Sechenov First Moscow State Medical University,
Ministry of Health of Russia. 119991, Russia, Moscow, Bolshaya Pirogovskaya str. 2, bld. 4. E-mail: ms_smith@list.ru
Uspenskaya Yulia Borisovna, PhD, leading researcher at Research Department of Women’s Health, I.M. Sechenov First Moscow State Medical University,
Ministry of Health of Russia. 119991, Russia, Moscow, Bolshaya Pirogovskaya str. 2, bld. 4
Gitel Evgenij Pavlovich, PhD, associate director on laboratory technologies at I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia.
119991, Russia, Moscow, Bolshaya Pirogovskaya str. 2, bld. 4
Vasilyeva Irina Vadimovna, senior researcher at Research Department of Women’s Health, I.M. Sechenov First Moscow State Medical University,
Ministry of Health of Russia. 119991, Russia, Moscow, Bolshaya Pirogovskaya str. 2, bld. 4
For citations: Vedzizheva E.R., Kuznetsova I.V., Uspenskaya Yu.B., Gitel E.P., Vasilyeva I.V.
On the pathogenesis of reproductive disorders in women with obesity.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (6): 18-24.(in Russian)
http://dx.doi.org/10.18565/aig.2017.6.18-24
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