Innovative approach to prediction and therapy of preeclampsia: global experience

Timokhina E.V., Strizhakov A.N., Zafiridi N.V., Gubanova E.S.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russian Federation
The article analyzes an update on the prediction of preeclampsia (PE) as a life-threatening condition for the mother and fetus. A biomarker with a high diagnostic value in predicting the severity of PE and its complications would be a significant progression, especially if it could also become the goal of targeted treatment. A search for a single biomarker to predict or diagnose PE is doomed to fail, since this complication has many causes. Angiogenic imbalance is considered to be leading. Placental ischemia results in the secretion and release of antiangiogenic factors (sFlt-, sEng, TGF-β receptor cofactor) into the maternal bloodstream, which are able to serve as markers of the development of PE in isolation or in combination. The authors analyze the PE prognostic approach adopted in the world’s leading centers. This review analyzes promising therapeutic approaches both to prevent PE and to increase its severity due to targeted effects on circulating angiogenic factors.

Keywords

preeclampsia
marker
sFlt-
sEng
plGF
statins

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Received 15.02.2019

Accepted 22.02.2019

About the Authors

Timokhina, Elena V., MD, professor of the Department of Obstetrics, Gynecology and Perinatology of the Medical Faculty, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia. 119991, Russia, Moscow, B. Pirogovskaya str. 2, bldg. 4. Tel.: +74997823045. E-mail: elena.timokhina@mail.ru
Strizhakov, Alexander N., academician of the RAS, professor, head of the Department of Obstetrics, Gynecology and Perinatology of the Medical Faculty, I.M. Sechenov
First Moscow State Medical University (Sechenov University), Ministry of Health of Russia. 119991, Russia, Moscow, Trubetskaya str. 8, bldg. 2. Tel.: +74997823045.
Zafiridi, Nikoleta V., postgraduate student of the Department of Obstetrics, Gynecology and Perinatology of the Medical Faculty, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia. 119991, Russia, Moscow, Trubetskaya str. 8, bldg. 2. Tel.: +74997823045. E-mail: kafedra-agp@mail.ru
Gubanova, Evgenia V., student of the Department of Obstetrics, Gynecology and Perinatology of the Medical Faculty, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia. 119991, Russia, Moscow, Trubetskaya str. 8, bldg. 2. Tel.: +74997823045. E-mail: kafedra-agp@mail.ru

For citation: Timokhina E.V., Strizhakov A.N., Zafiridi N.V., Gubanova E.S. Innovative approach to prediction and therapy of preeclampsia: global experience. Akusherstvo i Ginekologiya/Obstetrics and Gynecology.2019; (5): 5-10. (in Russian)
https://dx.doi.org/10.18565/aig.2019.5.5-10

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