Innovative approaches to high-intensity focused ultrasound treatment for vulvar diseases

Apolikhina I.A., Malyshkina D.A., Teterina T.A.

1) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia
Background. High Intensity Focused Ultrasound (HIFU) is a technique of local non-invasive exposure to high-frequency ultrasound on deeply located tissues of the body. HIFU has currently found its application in aesthetic gynecology, particularly in the treatment of benign vulvar diseases, including lichen sclerosus.
Case report. The authors present their own experience with HIFU used to treat two female patients with lichen sclerosus. The patients had a long history of lichen sclerosus and received repeated cycles of treatment with low-potency topical corticosteroids. The authors prescribed estrogen-containing Ovestin cream according to the standard regimen and one HIFU session. All the patients had a histological report confirming the diagnosis, which is necessary before HIFU exposure. After 3 and 6 months, the patients were invited to take part in repeat visits; the women noted the disappearance of itching complaints, and a local status improvement was visible even without optical equipment, which was then confirmed by a DySIS digital colposcope.
Conclusion. Our experience confirmed the clinical efficacy of HIFU in treating women with lichen sclerosus. Not a single relapse of the disease was detected 6 months after the session. The presented clinical case showed that it might be possible to achieve the desired effect by only one session.

Keywords

lichen sclerosus
high-intensity focused ultrasound (HIFU)
genitourinary syndrome of menopause

References

  1. Бэйли М.Р., Хохлова В.А., Сапожников О.А., Каргл С.Г., Крам Л.А. Физические механизмы воздействия терапевтического ультразвука на биологическую ткань (Обзор). Акустический журнал. 2003; 49(4): 437-64.[Bailey M.R., Khokhlova V A., Sapozhnikov O.A., Kargl S.G., Kram L.A. Physical mechanisms of the effect of therapeutic ultrasound on biological tissue (Review). Acoustic journal. 2003; 49(4): 437-64. (in Russian)].
  2. Корнеев Ю.А., Коршунов А.П., Погадаев В.И. Медицинская и биологическая физика. М.: Медицинская книга, Н. Новгород: Изд-во НГМА; 2011. 250с. [Korneev Yu.A., Korshunov A.P., Pogadaev V.I. Medical and biological physics. M .: Medical book, N. Novgorod: Publishing house of the NGMA; 2011. 250p. (in Russian)].
  3. Kovatcheva R., Guglielmina J.N., Abehsera M., Boulanger L., Laurent N., Poncelet E. Ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma – a multicenter experience. J Ther Ultrasound. 2015; 3(1):1. https://dx.doi.org/10.1186/s40349-014-0022-3.
  4. Гаврилов Л.Р. Фокусированный ультразвук высокой интенсивности в медицине. М.: Фазис; 2013. 656с. [Gavrilov L.R. Focused ultrasound of high intensity in medicine. M.: "Fazis"; 2013. 656 p. (in Russian)].
  5. Wu C., Zou M., Xiong Y., Wang L., Chen H., Fan Y., Li C. Short- and long-term efficacy of focused ultrasound therapy for non-neoplastic epithelial disorders of the vulva. BJOG. 2017; 124(Suppl. 3): 87-92. https://dx.doi.org/10.1111/1471-0528.14747.
  6. Горбунова Е.А., Аполихина И.А. «Белые пятна» на карте врачебных знаний. StatusPraesens. Гинекология, акушерство, бесплодный брак. 2015; 4: 92-9. [Gorbunova E.A., Apolikhina I.A. "White spots" on the map of medical knowledge. StatusPraesens. 2015; 4: 92-9. (in Russian)].

Received 26.03.2020

Accepted 10.06.2020

About the Authors

Inna A. Apolikhina, MD, Head of the Department of Aesthetic Gynecology and Rehabilitation, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; Professor of the Department of Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Professional Education, I.M. Sechenov First MSMU, Ministry of Health of Russia (Sechenov University). E -mail: i_apolikhina@oparina4.ru.
117997, Russia, Moscow, Akademika Oparina str., 4.
Darya A. Malyshkina, the 2nd year resident, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. E-mail: nidsumi@mail.ru. 117997, Russia, Moscow, Akademika Oparina str., 4.
Tatiana A. Teterina, PhD, obstetrician-gynecologist of the Department of Aesthetic Gynecology and Rehabilitation, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. E-mail: palpebra@inbox.ru. 117997, Russia, Moscow, Akademika Oparina str., 4.

For citation: Apolikhina I.A., Malyshkina D.A., Teterina T.A. Innovative approaches to high-intensity focused ultrasound treatment for vulvar diseases.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 12: 230-233 (in Russian)
https://dx.doi.org/10.18565/aig.2020.12.230-233

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