Modern aspects of management tactics for women with genitourinary syndrome of menopause
Pestrikova T.Yu., Kotelnikova A.V., Veselkova E.G., Yurasova E.A., Yurasov I.V., Strelnikova N.V.
Genitourinary syndrome of menopause is a chronic condition that occurs during the perimenopausal and menopausal periods. It is characterized by a wide range of symptoms and signs such as vaginal dryness, itching, burning, dyspareunia, bloody vaginal discharge, urinary disorders. These symptoms are caused by estrogen deficiency and tend to progress over time. Vulvovaginal atrophy and postmenopausal atrophic vaginitis are the most common manifestations.
Objective: To evaluate clinical, laboratory and instrumental parameters in postmenopausal women with atrophic vaginitis before and after topical application of estriol (50 µg/g).
Materials and methods: The study included 75 menopausal women with a verified diagnosis of postmenopausal atrophic vaginitis. The diagnosis was confirmed on the basis of the data obtained after clinical, laboratory and instrumental investigations. The monitoring of the patients included several visits where adequate topical therapy was administered and a number of follow-up examinations.
Results: The findings from the present study showed an improvement in clinical, laboratory and instrumental data of postmenopausal women with atrophic vaginitis during and after the treatment with ultra-low-dose estriol intravaginally (50 µg/g). There was a decrease in symptoms and clinical signs of vulvovaginal atrophy as well as normalization of vaginal microbiota in these women. The results of pelvic ultrasound obtained before, during and after the topical treatment with estriol showed neither an increase in M-echo of more than 5 mm, nor ovarian neoplasms or growth of myomatous nodes.
Conclusion: Intravaginal administration of ultra-low-dose estriol is considered to be a viable treatment option for women suffering from atrophic vaginitis.
Authors’ contributions: Pestrikova T.Yu. – developing the concept and design of the study, writing the text; Kotelnikova A.V., Veselkova E.G., Yurasova E.A., Yurasov I.V., Strelnikova N.V. – collecting and processing the material.
Conflicts of interest: Authors declare lack of the possible conflicts of interest.
Funding: The study was conducted without sponsorship.
Ethical Approval: The study was approved by the Ethical Review Board of the Far Eastern State Medical University, Ministry of Health of Russia (protocol No. 1 dated June 16, 2022).
Patient Consent for Publication: The patients signed informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Pestrikova T.Yu., Kotelnikova A.V., Veselkova E.G., Yurasova E.A., Yurasov I.V., Strelnikova N.V. Modern aspects of management tactics for women with genitourinary syndrome of menopause.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (3): 169-176 (in Russian)
https://dx.doi.org/10.18565/aig.2025.11
Keywords
genitourinary syndrome of menopause
vulvovaginal atrophy
topical hormonal therapy with vaginal gel containing ultra-low-dose estriol
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Received 22.02.2025
Accepted 14.03.2025
About the Authors
Tatyana Yu. Pestrikova, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Far Eastern State Medical University, Ministry of Health of Russia, 680000, Russia, Khabarovsk, Muravyov-Amursky str., 35, +7(914)771-93-83, typ50@rambler.ru, https://orcid.org/0000-0002-1120-846XAnastasia V. Kotelnikova, PhD, Teaching Assistant at the Department of Obstetrics and Gynecology, Far Eastern State Medical University, Ministry of Health of Russia, 680000, Russia, Khabarovsk, Muravyov-Amursky str., 35; Doctor at the Gynecological Department, Prof. A.M. Voino-Yasenetsky City Clinical Hospital, 680033, Russia, Khabarovsk, Tikhookeanskaya str., 213; Gynecologist, Multifunctional Medical Center «Dear Madeleine», 680000, Russia, Khabarovsk, Turgenev str., 49, +7(924)405-57-77, tempo-m@mail.ru, https://orcid.org/0000-0002-8143-5932
Elena G. Veselkova, PhD student at the Department of Obstetrics and Gynecology, Far Eastern State Medical University, Ministry of Health of Russia,
680000, Russia, Khabarovsk, Muravyov-Amursky str., 35; Gynecologist, Multifunctional Medical Center «Dear Madeleine», 680000, Russia, Khabarovsk, Turgenev str., 49, +7(914)779-45-51, dr.veselkova@inbox.ru, https://orcid.org/0009-0007-4339-6665
Elena A. Yurasova, Dr. Med. Sci., Professor, Department of Obstetrics and Gynecology, Far Eastern State Medical University, Ministry of Health of Russia,
680000, Russia, Khabarovsk, Muravyov-Amursky str., 35, +7(962)583-82-55, urasovaea@yandex.ru, https://orcid.org/0000-0002-7771-3549
Igor V. Yurasov, Dr. Med. Sci., Professor, Department of Obstetrics and Gynecology, Far Eastern State Medical University, Ministry of Health of Russia, 680000, Russia, Khabarovsk, Muravyov-Amursky str., 35; Head of the Gynecological Department, Prof. A.M. Voino-Yasenetsky City Clinical Hospital, 680033, Russia, Khabarovsk, Tikhookeanskaya str., 213, https://orcid.org/0000-0001-6397-7052
Natalia V. Strelnikova, PhD, Associate Professor, Department of Microbiology, Virology, Immunology, Far Eastern State Medical University, Ministry of Health of Russia, 680000, Russia, Khabarovsk, Muravyov-Amursky str., 35, +7(924)925-89-85, jpdom@mail.ru, https://orcid.org/0000-0002-1749-1323
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