Hormone therapy for functional ovarian cysts

Dubrovina S.O., Berlim Yu.D., Gimbut V.S., Vovkochina M.A.

Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don, Russia
The review paper deals with the prevalence of functional ovarian cysts and the pathogenetic aspects of their formation and management tactics. Particular emphasis is laid on the justification of ineffective hormonal therapy for functional cysts. Consideration is given to the process of follicular cyst formation in the use of dydrogesterone.


functional cysts
hormone therapy


  1. Grimes D.A., Jones L.B., Lopez L.M., Schulz K.F. Oral contraceptives for functional ovarian cysts. Cochrane Database Syst. Rev. 2011; (9): CD006134. https://dx.doi.org/10.1002/14651858.CD006134.pub4.
  2. Li C.Z., Wei D.Y., Wang F. Impact on ovarian reserve function by different homostasis methods during laparoscopic cystectomy in treatment of ovarian endometrioma. Zhonghua Fu Chan Ke Za Zhi. 2013; 48(1): 11-5.
  3. Ross E.K., Kebria M. Incidental ovarian cysts: when to reassure, when to reassess, when to refer. Cleve Clin. J. Med. 2013; 80(8): 503-14. https://dx.doi.org/10.3949/ccjm.80a.12155.
  4. Langer J.E., Oliver E.R., Lev-Toaff A.S., Coleman B.G. Imaging of the female pelvis through the live cycle. Radiographics. 2012; 32(6): 1575-97. https://dx.doi.org/1010.1148/rg.326125513.
  5. Laing F.C., Allison S. US of the ovary and adnexa: to worry or not to worry? Radiographics. 2012; 32(6): 1621-39. https://dx.doi.org/10.1148/rg.326125512.
  6. Ackerman S., Irshad A., Lewis M., Anis M. Ovarian cystic lesions a current approach to diagnosis and management. Radiol. Clin. North. Am. 2013; 51(6): 1067-85. https://dx.doi.org/10.1016/j.rcl.2013.07.010.
  7. Pascual A., Hereter L., Tresserra F., Carreras O., Ubeda A., Dexeus S. Transvaginal sonographic appearance of functional ovarian cysts. Hum. Reprod. 1997; 12(6): 1246-9.
  8. Froyman W., Landolfo C., De Cock B., Wynants L., Sladkevicius P., Testa A.C. et al. Risk of complications in patients with conservatively managed ovarian tumours (IOTA5): a 2-year interim analysis of a multicentre, prospective, cohort study. Lancet Oncol. 2019; 20(3): 448-58. https://dx.doi.org/10.1016/S1470-2045(18)30837-4.
  9. Van Calster B., Valentin L., Van Holsbeke C., Zhang J., Jurkovic D., Lissoni A.A.et al. A novel approach to predict the likelihood of specific ovarian tumor pathology based on serum CA-125: a multicenter observational study. Cancer Epidemiol. Biomarkers Prev. 2011; 20(11): 2420-8. https://dx.doi.org/10.1158/1055-9965.EPI-11-0422.
  10. Biggs W.S., Marks S.T. Diagnosis and management of adnexal masses. Am. Fam. Physician. 2016; 93(8): 676-81.
  11. Kaijser J., Sayasneh A., Van Hoorde K., Ghaem-Maghami S., Bourne T., Timmerman D., Van Calster B. Presurgical diagnosis of adnexal tumours using mathematical models and scoring systems: a systematic review and meta-analysis. Hum. Reprod. Update. 2014; 20(3): 449-62. https://dx.doi.org/10.1093/humupd/dmt059.
  12. Levine D., Brown D.L., Andreotti R.F., Benacerraf B., Benson C.B., Brewster W.R. et al. Management of asymptomatic ovarian and other adnexal cysts imaged at US: Society of Radiologists in Ultrasound Consensus Conference Statement. Radiology. 2010; 256(3): 943-54. https://dx.doi.org/10.1148/radiol.10100213.
  13. Atri M., Alabousi A., Reinhold C., Akin E.A., Benson C.B., Bhosale P.R. et al. Expert panel on women’s imaging. ACR Appropriateness Criteria clinically suspected adnexal mass, no acute symptoms. J. Am. Coll. Radiol. 2019; 16(5, Suppl.): S77-93. https://dx.doi.org/10.1016/j.jacr.2019.02.011.
  14. American College of Obstetricians and Gynecologists. ACOG Practice Bulletin. Management of adnexal masses. Obstet. Gynecol. 2007; 110(1): 201-14. https://dx.doi.org/10.1097/01.AOG.0000263913.92942.40.
  15. Liu J.H., Zanotti K.M. Management of the adnexal mass. Obstet. Gynecol. 2011; 117(6): 1413-28. https://dx.doi.org/10.1097/AOG.0b013e31821c62b6.
  16. Higgins R.V., Matkins J.F., Marroum M.C. Comparison of fine-needle aspiration cytologic findings of ovarian cysts with ovarian histologic findings. Am. J. Obstet. Gynecol. 1999; 180(3, Pt1): 550-3. https://dx.doi.org/10.1016/s0002-9378(99)70252-8.
  17. Zanetta G., Lissoni A., Torri V., Dalla Valle C., Trio D., Rangoni G., Mangioni C. Role of puncture and aspiration in expectant management of simple ovarian cysts: a randomised study. BMJ. 1996; 313(7065): 1110-3. https://dx.doi.org/10.1136/bmj.313.7065.1110.
  18. Bonilla-Musoles F., Ballester M.J., Simon C., Serra V., Raga F. Is avoidance of surgery possible in patients with perimenopausal ovarian tumors using transvaginal ultrasound and duplex color Doppler sonography? J. Ultrasound Med. 1993; 12(1): 33-9. https://dx.doi.org/10.7863/jum.1993.12.1.33.
  19. Doret M., Raudrant D. Functional ovarian cysts and the need to remove them. Eur. J. Obstet. Gynecol. Reprod. Biol. 2001; 100(1): 1-4. https://dx.doi.org/10.1016/s0301-2115(01)00443-2.
  20. Seehusen D.A., Earwood J.S. Oral contraceptives are not an effective treatment for ovarian cysts. Am. Fam. Physician. 2014; 90(9): 623.
  21. Vercellini P., Buggio L., Frattaruolo M.P., Borghi A., Dridi D., Somigliana E. Medical treatment of endometriosis-related pain. Best Pract. Res. Clin. Obstet. Gynaecol. 2018; 51: 68-91. https://dx.doi.org/10.1016/j.bpobgyn.2018.01.015.
  22. Santulli P., Marcellin L., Menard S., Thubert T., Khoshnood B., Gayet V. et al. Increased rate of spontaneous miscarriages in endometriosis-affected women. Hum. Reprod. 2016; 31(5): 1014-23. https://dx.doi.org/10.1093/humrep/dew035.
  23. Vercellini P., Buggio L., Berlanda N., Barbara G., Somigliana E., Bosari S. Estrogen-progestins and progestins for the management of endometriosis. Fertil. Steril. 2016; 106(7): 1552-71. https://dx.doi.org/10.1016/j.fertnstert.2016.10.022.

Received 24.04.2020

Accepted 27.04.2020

About the Authors

Svetlana O. Dubrovina, MD; Professor, Principal Researcher, Research Institute of Obstetrics and Pediatrics, Rostov State Medical University, Ministry of Health of Russia. Tel.: 8-918-558-51-13. E-mail: s. dubrovina@gmail.com. https://orcid. org/0000-0003-2424-2672
Address: 43/38/2, Mechnikov St., Rostov-on-Don 344012, Russia
Yulia D. Berlim, Cand. Med. Sci.; Head, Consulting and Outpatient Department, Rostov State Medical University, Ministry of Health of Russia. Tel.: 8 (918) 500-23-56.
E-mail: juliaberlim@yandex.ru; https://orcid.org/0000-0003-4582-0988
Address: 29, Nakhichevansky Lane, Rostov-on-Don 344022, Russia
Vitaly S. Gimbut, Cand. Med. Sci.; Senior Researcher, Research Institute of Obstetrics and Pediatrics, Rostov State Medical University, Ministry of Health of Russia.
Tel.: 8-863-232-18-40. E-mail: vgimbut@gmail.com. https://orcid.org/0000-0002-5608-5328 .
Address: 43/38/2, Mechnikov St., Rostov-on-Don 344012, Russia
Marinа A. Vovkochina, Obstetrician/Gynecologist, Research Institute of Obstetric and Pediatrics, Rostov State Medical University, Ministry of Health of Russia.
Tel.: 8-918-559-00-30. E-mail: Jordan-85@inbox.ru
Address: 43/38/2, Mechnikov St., Rostov-on-Don 344012, Russia

For reference: Dubrovina S.O., Berlim Yu.D., Gimbut V.S., Vovkochina M.A. Hormone therapy for functional ovarian cysts.
Akusherstvo i Ginekologiya. 2020; 4:210-213

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