Hyperprolactinemia in obstetrics and gynecology practice

Ilovaiskaya I.A.

M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow 129110, Shchepkina str. 61/2, bld. 9, Russia
Objective. To make a critical review of international and federal clinical guidelines for the diagnosis and treatment of hyperprolactinemia.
Subjects and methods. The recent clinical guidelines of the American Society of Endocrinology and the Russian Association of Endocrinologists, as well as the data of foreign and Russian articles on hyperprolactinemia, published in the past 7 years and found in Pubmed, were used.
Results. Indications to rule out pathological hyperprolactinemia were formulated and specific recommendations described for a practicing obstetrician/gynecologist.
Conclusion. It is necessary to strictly follow all mandatory international and federal clinical guidelines, which will allow the practitioner to enhance the effectiveness of medical care.

Keywords

hyperprolactinemia
prolactinoma
diagnosis
treatment
cabergoline
clinical guidelines

References

1. Melnichenko G.A., Dzeranova L.K., Pigarova E.A., Vorotnikova S.Yu., Rozhinskaya L.Ya., Dedov I.I. Federal clinical guidelines for the clinic, diagnosis, differential diagnosis and treatment of hyperprolactinemia. 2013; 59(6): 19-26. (in Russian)

2. Melmed S., Casanueva F.F., Hoffman A.R., Kleinberg D.L., Montori V.M., Schlechte J.A. et al. Diagnosis and treatment of hyperprolactinemia: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 2011; 96(2): 273-88. doi: 10.1210/jc.2010-1692.

3. Dedov I.I., Melnichenko G.A., ed. Rational pharmacotherapy of endocrine system diseases and metabolic disorders. 2nd ed. Moscow: Litterra; 2013. 1024p. (in Russian)

4. Dedov I.I., Melnichenko G.A., ed. Endocrinology. National guideline. 2nd ed. Moscow: GEOTAR-Media; 2016. 1112p. (in Russian)

5. Capozzi A., Scambia G., Pontecorvi A., Lello S. Hyperprolactinemia: pathophysiology and therapeutic approach. Gynecol. Endocrinol. 2015; 31(7): 506-10.

6. Whyte M.B., Pramodh S., Srikugan L., Gilbert J.A., Miell J.P., Sherwood R.A. et al. Importance of cannulated prolactin test in the definition of hyperprolactinaemia. Pituitary. 2015; 18(3): 319-25. doi: 10.1007/s11102-014-0576-7.

7. Maiter D., Primeau V. Update in the treatment of prolactinomas. Ann. Endocrinol. (Paris). 2012; 73(2): 90-8. doi: 10.1016/j.ando.2012.03.024.

8. De Hert M., Detraux J., Peuskens J. Second-generation and newly approved antipsychotics, serum prolactin levels and sexual dysfunctions: a critical literature review. Expert Opin. Drug Saf. 2014;13(5): 605-24.

9. Samson S.L., Hamrahian A.H., Ezzat S.; AACE Neuroendocrine and Pituitary Scientific Committee; American College of Endocrinology (ACE). American Association of Clinical Endocrinologists, American College of Endocrinology disease state clinical review: clinical relevance of macroprolactin in the absence or presence of true hyperprolactinemia. Endocr. Pract. 2015; 21(12): 1427-35. doi: 10.4158/EP15938.DSC.

10. Kars M., Souverein P.C., Herings R.M., Romijn J.A., Vandenbroucke J.P., de Boer A., Dekkers O.M. Estimated age- and sex-specific incidence and prevalence of dopamine agonist-treated hyperprolactinemia. J. Clin. Endocrinol. Metab. 2009; 94(8): 2729-34. doi: 10.1210/jc.2009-0177.

11. Dos Santos Nunes V., El Dib R., Boguszewski C.L., Nogueira C.R. Cabergoline versus bromocriptine in the treatment of hyperprolactinemia: a systematic review of randomized controlled trials and meta-analysis. Pituitary. 2011; 14(3): 259-65. doi: 10.1007/s11102-010-0290-z.

12. Wang A.T., Mullan R.J., Lane M.A., Hazem A., Prasad C., Gathaiya N.W. et al. Treatment of hyperprolactinemia: a systematic review and meta-analysis. Syst. Rev. 2012; 1: 33. doi: 10.1186/2046-4053-1-33.

13. Glezer A., Bronstein M.D. Prolactinomas, cabergoline, and pregnancy. Endocrine. 2014; 47(1): 64-9. doi: 10.1007/s12020-014-0334-7.

14. Auriemma R.S., Perone Y., Di Sarno A., Grasso L.F., Guerra E., Gasperi M. et al. Results of a single-center observational 10-year survey study on recurrence of hyperprolactinemia after pregnancy and lactation. J. Clin. Endocrinol. Metab. 2013; 98(1): 372-9.

15. Rastogi A., Bhadada S.K., Bhansali A. Pregnancy and tumor outcomes in infertile women with macroprolactinoma on cabergoline therapy. Gynecol. Endocrinol. 2016; Dec 2: 1-4. doi: 10.1080/09513590.2016.1254177.

16. Hu J., Zheng X., Zhang W., Yang H. Current drug withdrawal strategy in prolactinoma patients treated with cabergoline: a systematic review and meta-analysis. Pituitary. 2015; 18(5): 745-51. doi: 10.1007/s11102-014-0617-2.

17. D’Sylva C., Khan T., Van Uum S., Fraser L.A. Osteoporotic fractures in patients with untreated hyperprolactinemia vs. those taking dopamine agonists: A systematic review and meta-analysis. Neuroendocrinol. Lett. 2015; 36(8):745-9.

18. Medic-Stojanoska M., Icin T., Pletikosic I., Bajkin I., Novakovic-Paro J., Stokic E. et al. Risk factors for accelerated atherosclerosis in young women with hyperprolactinemia. Med. Hypotheses. 2015; 84(4): 321-6. doi: 10.1016/j.mehy.2015.01.024.

19. Krysiak R., Okopien B. Different effects of cabergoline and bromocriptine on metabolic and cardiovascular risk factors in patients with elevated prolactin levels. Basic Clin. Pharmacol. Toxicol. 2015; 116(3): 251-6. doi: 10.1111/bcpt.12307.

20. Bolanowski M., Zadrozna-Sliwka B., Jawiarczyk A., Syrycka J. The influence of other than prolactin hormones on bone mineral density in women with hyperprolactinaemia of various origins. Gynecol. Endocrinol. 2010; 26(8): 623-7. doi: 10.3109/09513591003686320.

21. Mazziotti G., Mancini T., Mormando M., De Menis E., Bianchi A., Doga M. et al. High prevalence of radiological vertebral fractures in women with prolactin-secreting pituitary adenomas. Pituitary. 2011; 14(4): 299-306. doi: 10.1007/s11102-011-0293-4.

22. dos Santos Silva C.M., Barbosa F.R., Lima G.A., Warszawski L., Fontes R., Domingues R.C. et al. BMI and metabolic profile in patients with prolactinoma before and after treatment with dopamine agonists. Obesity (Silver Spring). 2011; 19(4): 800-5. doi: 10.1038/oby.2010.150.

Received 07.02.2017

Accepted 17.02.2017

About the Authors

Ilovaiskaya Irena Adolfovna, Ph.D., Associate Professor, Senior Researcher, Department of therapeutic endocrinology,
M.F. Vladimirsky Moscow Regional Research Clinical Institute. 129110, Russia, Moscow, Shchepkina str. 61/2, bld. 9. Tel.: +79015453809. E-mail: irena.ilov@yandex.ru

For citations: Ilovayskaya I.A. Hyperprolactinemia in obstetric/gynecological practice. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (4): 149-54. (in Russian)
http://dx.doi.org/10.18565/aig.2017.4.149-54

Similar Articles

By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.