Giant hemangioma of the placenta
Background. Placental hemangioma belongs to the group of nontrophoblastic tumors.Tumanova U.N., Lyapin V.M., Shchegolev A.I., Baev O.R., Prikhodko A.M., Kozhina E.A., Khodzhaeva Z.S.
Case report. The paper gives a case of giant placental hemangioma detected at 32 weeks’ gestation. It also describes the course of labor at 35 weeks of pregnancy. There are computed tomographic, histological, and immunohistochemical data on the born placenta. There are also literature data on histological characteristics of the structure of placental hemangiomas, as well as possible pregnancy and labor complications. It is noted that the obstetric tactics for hemangioma mainly depends on its size and the status of the fetus.
Conclusion. An observation of giant placental hemangioma is of interest due to its relative rarity and little knowledge of such tumors concerning their importance for fetal development and possible pregnancy complications. The choice of optimum obstetric tactics of management and delivery for pregnant women with placental hemangioma is of importance.
Keywords
hemangioma
chorangioma
placenta
obstetric tactics
computed tomography
Supplementary Materials
- Table 1. Immunohistochemical characteristics of hemangioma cells and extratumoral zone of the placenta
- Fig. 1. Ultrasound image. Pregnancy 32 weeks 2 days. On the edge of the placenta in the subamniotic region seen neoplasm, which has a solid structure with clear contours, size 10.0 × 8.6 × 12.1 cm, prolapsing into the amniotic cavity.
- Fig. 2. Macroscopic characteristics of the hemangioma of placenta. a - an outside view, б - a view on a section
- Fig. 3. Computer-tomographic characteristics of the hemangioma of placenta. Volume reconstruction of CT tomograms: a - giant hemangioma of the fetal part of the placenta; b - loose type of distribution of blood vessels of the placenta, dense vasculature in the hemangioma area, view from the fetal surface; c - the main vessels of the hemangioma, the view from the maternal surface
- Fig. 4. Histological (a) and immunohistochemical (b-d) characteristics of the hemangioma of placenta. a - a capillary hemangioma, b - CD34 expression in endothelial cells, c - VEGF expression in endothelial cells, d - CK7 expression in trophoblasts. a - staining with hematoxylin and eosin, b-d - immunoperoxidase method; a, b, d - Х 100, c – Х 200
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Received 09.06.2017
Accepted 23.06.2017
About the Authors
Tumanova Ulyana Nikolaevna, researcher of pathoanatomical department, Research Center for Obstetrics, Gynecology and Perinatology,Ministry of Health of Russian Federation. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +7495314444. E-mail: ashegolev@oparina4.ru
Lyapin Vyacheslav Michailovich, pathologist, pathoanatomical department, Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russian Federation. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74955314444. E-mail: v_lyapin@oparina4.ru
Shchegolev Aleksandr Ivanovich, MD, professor, Head of pathoanatomical department, Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russian Federation. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74955314444. E-mail: ashegolev@oparina4.ru
Baev Oleg Radomirovich, MD, Head of maternity department, Research Center of Obstetrics, Gynecology and Perinatology Ministry of Health of Russian Federation.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381188. E-mail: o_baev@oparina4.ru
Prikhodko Andrey Mikhailovich, PhD, physician of maternity department, Research Center of Obstetrics, Gynecology and Perinatology
Ministry of Health of Russian Federation. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954383047. E-mail: a_prikhodko@oparina4.ru
Kozhina Ekaterina Aleksandrovna, student of the 6th year of M.V. Lomonosov Moscow State University. 119991, Russia, Moscow, Leninskie Gory, 1
Khodzaeva Zulfiya Sagdullaevna, MD, professor, senior researcher, Research Center of Obstetrics of Gynecology and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: z_khodzhaeva@mail.ru
For citations: Tumanova U.N., Lyapin V.M., Shchegolev A.I., Baev O.R., Prikhodko A.M., Kozhina E.A., Khodzhaeva Z.S. Giant hemangioma of the placenta. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (10): 136-43. (in Russian)
https://dx.doi.org/10.18565/aig.2017.10.136-143
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