Genes involved in premature ovarian failure

DOI

https://dx.doi.org/10.18565/aig.2021.11.71-80

Chernukha G.E., Tabeeva G.I., Rshtuni S.D., Mashaeva R.I., Chernykh V.B., Marchenko L.A.
1) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia; 2) Academician N.P. Bochkov Research Center for Medical Genetics, Moscow, Russia

Premature ovarian failure (POF) is a clinical syndrome characterized by secondary amenorrhea in the presence of high FSH levels in women under the age of 40 years. The incidence of this pathology is progressively rising and currently amounting for 3–4%. Premature depletion of the ovarian reserve may be related to both genetic and environmental factors and their combination, including infectious, toxic, and autoimmune damage to the ovaries, as well as to chromosomal abnormalities, genetic variants, and epigenetic factors. This review identifies a panel of the most significant candidate genes involved in the genesis of POF, such as NANOS3, FIGLA, FOXO3, NR5A1, NOBOX, BMP15, GDF9, PGRMCI, PTEN, and BRCA1,2. These genes are responsible for a key role in early folliculogenesis, including for the formation of primary follicles and for the production of the zona pellucida, for their growth to the FSH-dependent stage, for the inhibition of FSH receptor mRNA expression in granulosa cells, thereby preventing the premature luteinization of follicles, as well as for early steroidogenesis and regulation of apoptotic processes in primordial follicles.
Conclusion: Knowledge of candidate genes underlying the genesis of POF, as well as the possibility of performing whole exome sequencing in clinical practice will be of defined value not only in understanding the physiology of the ovaries, but also for genetic counseling to make an early (preclinical) diagnosis of POF.

candidate genes

neхt-generation sequencing

premature ovarian failure

Full text (in Russian)

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Received 25.06.2021

Accepted 14.10.2021

Galina E. Chernukha, Dr. Med. Sci., Professor, Department of Endocrinological Gynecology, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Healthcare of Russian Federation, g_chernukha@oparina4.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.
Gyuzyal I. Tabeeva, Senior Researcher of the Department of Gynecological Endocrinology, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Healthcare of Russian Federation, +7(903)199-72-82, doctor.gtab@gmail.com, 117997, Russia, Moscow, Ac. Oparina str., 4.
Sandra D. Rshtuni, postgraduate student, Department of Endocrinological Gynecology, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Healthcare of Russian Federation, rshtunisandra@gmail.com, 117997, Russia, Moscow, Ac. Oparina str., 4.
Roza I. Mashaeva, postgraduate student, Department of Endocrinological Gynecology, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Healthcare of Russian Federation, mashaevarosa@gmail.com, 117997, Russia, Moscow, Ac. Oparina str., 4.
Vyacheslav B. Chernykh, Dr. Med. Sci., Bochkov Research Centre for Medical Genetics, Pirogov Russian National Research Medical University, chernykh@med-gen.ru,
https://orcid.org/0000-0003- 2719-503, 115522, Russia, Moscow, Moskvorechye str., 1.
Larisa A. Marchenko, Dr. Med. Sci., Professor, Department of Endocrinological Gynecology, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Healthcare of Russian Federation, l_marchenko@yandex.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.

Authors’ contributions: Mashaeva R.I., Rshtuni S.D. – review of literature; Marchenko L.A., Rshtuni S.D., Mashaeva R.I. – writing the text; Chernykh V.B., Chernukha G.E., Tabeeva G.I. – editing the text.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The article has been written within the framework of the state assignment “Elaboration of innovative approaches to the prediction and preclinical diagnosis of premature ovarian failure, by identifying molecular genetic and clinical hormonal markers in the female representatives of the Russian population in different age periods”, No. 121032500121-8, Internal No. 17-A21.
For citation: Chernukha G.E., Tabeeva G.I., Rshtuni S.D., Mashaeva R.I., Chernykh V.B., Marchenko L.A. Genes involved in premature ovarian failure.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 11: 71-80 (in Russian)
https://dx.doi.org/10.18565/aig.2021.11.71-80

Genes involved in premature ovarian failure

Chernukha G.E., Tabeeva G.I., Rshtuni S.D., Mashaeva R.I., Chernykh V.B., Marchenko L.A.

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