Empirical therapy for vulvovaginitis in reproductive-aged women in routine clinical practice

Radzinsky V.E., Anufrieva V.G., Belinina A.A., Bespalaya A.V., Dolgushina V.F., Zhilno E.Yu., Zazerskaya I.E., Katkova N.Yu., Klimova O.I., Korotkikh I.N., Kravchenko E.N., Kutsenko I.G., Lebedenko E.Yu., Loseva V.V., Mingaleva N.V., Molchanova I.V., Ordiyants I.M., Padrul M.M., Pashov A.I., Protopopova N.V., Rosyuk E.A., Rymashevsky M.A., Sablina N.V., Salov I.A., Sokolova T.M., Spiridonova N.V.

1) Peoples’ Friendship University of Russia, Moscow, Russia; 2) Rostov State Medical University, Rostov-on-Don, Russia; 3) Altai Territorial Clinical Perinatal Center, Barnaul, Russia; 4) Rostov Perinatal Center, Rostov-on-Don, Russia; 5) South Ural State Medical University, Chelyabinsk, Russia; 6) V.I. Razumovsky Saratov State Medical University, Saratov, Russia; 7) V.A. Almazov National Medical Research Center, Saint Petersburg, Russia; 8) Volga Research Medical University, Nizhny Novgorod, Russia; 9) N.N. Burdenko Voronezh Medical University, Voronezh, Russia; 10) Omsk State Medical University, Omsk, Russia; 11) Siberian State Medical University, Tomsk, Russia; 12) Immanuel Kant Baltic Federal University, Kaliningrad, Russia; 13) Kuban State Medical University, Krasnodar, Russia; 14) Academician E.A. Vagner Perm State Medical University, Perm, Russia; 15) Irkutsk State Medical University, Irkutsk, Russia; 16) Ural State Medical University, Yekaterinburg, Russia; 17) S.P. Botkin City Clinical Hospital, Moscow, Russia; 18) Novosibirsk State Medical University, Novosibirsk, Russia; 19) Samara State Medical University, Samara, Russia

Objective. To evaluate the efficiency of empirical therapy with tergynan in reproductive-aged women in routine clinical practice.
Subjects and methods. The TERRA multicenter post-registration observational study enrolled 430 reproductive-aged patients diagnosed with acute vulvovaginitis. Based on their complaints, clinical symptoms, and objective examination, the patients received empirical therapy with the combination antimicrobial drug Tergynan as a single vaginal tablet once daily for 10 days. Gynecological examination, pH-metry, and bacterioscopic and bacteriological examinations of discharge (Femoflor-16) were performed, and the time course of changes in clinical symptoms evaluated.
Results. There was less vaginal discharge, a complete disappearance of unpleasant odor, and a feeling of vaginal itching and burning (74.5 and 67.1%, respectively). There were increases in the detection rate of Lactobacillus spp. by 2 times with a dissemination level of 106-107 CFU/ml, in the suppression of obligate anaerobic representatives (associations of Gardnerella vaginalis + Prevotella bivia + Porphyromonas spp., as well as Eubacterium spp.) by 5 times, facultative anaerobic bacteria (Enterobacteriaceae and Streptococcus spp.) by 3 times, and yeast-like fungi of the genus Candida by 2 times.
Conclusion. This investigation demonstrated the high clinical (96.5%) and microbiological (97.3%) efficiency of empirical therapy with tergynan in 430 reproductive-aged women with acute nonspecific vulvovaginitis

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References

About the Authors

Victor E. Radzinskiy, Merit scientist of the Russian Federation, corresponding member RAS, Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology with a course of perinatology of the Medical Institute of RUDN University. Tel.: +7 (499) 936-87-87, E-mail: radzinsky@mail.ru
117198 Russia, Moscow, Miklukho-Maklaya str, 6.
Vitaliya G. Anufrieva, obstetrician-gynecologist,  gynecologic department, Rostov State Medical University, Ministry of Health of Russia. Tel.: 8(863)2343866.  
E-mail: vitaliya@list.ru
344022, Russia, Rostov-on-Don, per. Nahichevanskiy, 29.
Antonina A. Belinina, candidate of medical sciences, assistant of the Department of Obstetrics and Gynecology with a course DPO FSBEI HE “Altai State Medical University”, deputy chief physician for quality control and safety of medical activities, KGBUZ “Altai Regional Clinical Perinatal center. Tel.: +7 (3852) 566-946
656019, Russia, Altayskiy kray, Barnaul, ul. Fomina, 154.
Angelina V. Bespalaya, оbstetrician-gynecologist of the birth Department, State Perinatal center of the Rostov region. Tel.: +7(863)235-50-18.
E-mail: angelina-koshka@yandex.ru
344068, Russia, Rostov-on-Don, Bodraya st, 90.
Valentina F. Dolgushina, Doctor of Medicine, professor, Head of the Department of Obstetrics and Gynecology, South Ural State Medical University, the Main freelance obstetrician-gynecologist for children and adolescents of the Ministry of Health of the Chelyabinsk Region. Tel.:+7 (351)7412283. E-mail: dolgushinavf@yandex.ru
454092, Russia, Chelyabinsk, ul. Vorovskogo, 15V.
Ekaterina Y. Zhilno, Candidate of Medical Sciences, Assistant of the Department of the Saratov State Medical University. Tel.:+7 (845-2)66-97-00
410012, Russia Volga Federal District, Saratov Region. Saratov, ul. Big Cossack, 112.
Irina E Zazerskaya., Doctor of Medicine, Professor, Head of the Department of Obstatrics and Gynecology, FSBISRC named after V.A. Almazova, St. Petersburg,
Tel.:+7 (812) 702-37-49. E-mail: zazerskaya@almazovcentre.ru
197341, Russia, St. Petersburg, ul. Akkuratova, 2.
Nadezhda Y. Katkova, Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology, Volga Research Medical University, Volga Research Medical University. Tel.:+7 (831) 4657575, katkova_nu@inbox.ru
603005, Russia, Nizhny Novgorod, pl. Minin and Pozharsky, d10 / 1.
Olga I Klimova., Candidate of Medical Sciences, Associate Professor, Department of Obstetrics, Gynecology and Reproductive Medicine1 FNMO.
Tel.:+7 (499) 936-87-87. E-mail: koiv01@mail.ru
117198, Russia, Moscow, Miklukho-Maklaya str, 6
Irina N. Korotkikh, Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology No. 1, Faculty of Medicine, FSBEI HE“Voronezh State Medical University named after N.N. Burdenko. Tel.:+7 (473) 257-96-74. E-mail: korotkikh_1950@mail.ru
394066 Russia,Voronezh, Moskovsky pr., 151.
Elena N. Kravchenko, Doctor of Medicine, professor, Head of the Department of Obstetrics and Gynecology, DPO Omsk State Medical University. Tel.:+7 (381)2 -957-012. E-mail: kravchenko.en@mail.ru
644099, Russia, Оmsk region, Omsk, Lenina ul, 12,
Irina G. Kutsenko, Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology, Siberian State Medical University. Tel.:+7 (3822) 901-101.
E-mail: irinakutcenko@mail.ru
634050,  Russia, Томsk, Моscow tract, 2.
Elizaveta Lebedenko Yu., Doctor of Medicine, Professor of the Department of Obstetrics and Gynecology, Rostov State Medical University, Ministry of Health of Russia.
Tel.:+7 (863) 252-24-65. E-mail: Lebedenko08@mail.ru
344022, Russia, Rostov-on-Don, per. Nahichevanskiy, 29.
Natalia V. Mingalyova, MD, pMD, professor of the Department of Obstetrics and gynecology FPK and PPS KubSMU, chief freelance specialist for outpatient obstetric and gynecological care of the Ministry of Health of the Krasnodar Krai, Tel.:+7 (861) 222-01-14.E-mail: mingalevan008@yandex.ru
350012, Russia, Krasnodar, st. Red Partisans, 6.
Irina V. Molchanova, Chief freelance specialist in obstetrics and gynecology of the Altai Territory, Chief physician of the Altai Territory Perinatal Center. E-mail: Molcanova2008@yandex.ru.
656045, Russia, Altayskiy kray, Barnaul, st. Fomina, 154. Tel.: +7 (3852)56-93-11
Irina M. Ordiyants, MD, professor of the Department of Obstetrics and Gynecology with a course of perinatolo gy of the Medical Institute of RUDN University.
Tel.:+7 (499) 936-87-87, E-mail: ordiyantc@mail.ru
117198, Russia, Moscow, st. Miklukho-Maklaya, 6.
Mikhail M. Padrul, Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology, Perm State Medical University named
after Academician E.A. Wagner. Tel.:+7 (342) 217-20-20, E-mail: m-padrul@mail.ru
614000, Russia, Perm, Petropavlovskaya St 26.
Alexander I. Pashov, MD, professor, head of the Department of Obstetrics and Gynecology, BFU im. Kant. GAU KO Regional Perinatal Center.
Tel.:+7 (4012) 313-233. E-mail: pachov@mail.ru
236023, Russia, Kaliningrad, Kaliningrad region, al. Kashtanov, 145.
Natalia V. Protopopova,MD, professor, Head of the Department of Obstetrics and Gynecology IGMAPO - branch of FSBEI DPO RMANPO, Honored doctor of RF.
Tel.:+7 (3952)40-79-10. E-mail: doc_protopopova@mail.ru
664079 Russia, Irkutsk, m/r Yubileyniy, 100,
Elena A. Rosyuk, candidate of medical sciences, associate professor of the Department of Obstetrics and Gynecology FSBEI HE «UMMU». Tel.: +7 (343) 214 86 52.
E-mail: elenakdc@yandex.ru.
620028, Russia, Yekaterinburg, ul. Repina, 3
Igor A. Salov, MD, professor. chief freelance specialist in obstetrics and gynecology of the Saratov region, chief doctor of the State Health Institution Saratov City Clinical Hospital No. 1 named after Yu. Y. Gordeeva. (8452) 51-51-28, E-mail: salov.i.a@mail.ru
410056, Russia, Saratov, st. Khuslyanova, 19.
Tatyana M. Sokolova, MD, professor of the Department of Obstetrics and Gynecology of the medical faculty of NSMU; Tel.:+7(383) 222-32-04. E-mail: tatyana3965@mail.ru
630087, Russia, Siberian Federal District, Novosibirsk Region, Novosibirsk, Krasny prospect, 130.
Natalya V. Spiridonova, Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology IPO Samara State Medical University, Chief freelance specialist in Obstetrics and Gynecology of the Samara region, Tel.:+7 (846) 333-01-56, E-mail: nvspiridonova@mail.ru
443099, Samara, ul. Polevaya 80.
Rymashevskkii Mikhail A., assistant of the Department of Obstetrics and Gynecology, Rostov State Medical University, Ministry of Health of Russia.
Tel.: +7(863)285-32-13, mikhail.rymashevskiy@mail.ru
344022, Russia, Rostov-on-Don, per. Nahichevanskiy, 29.
Natalya V. Sablina, obstetrician-gynecologist,  gynecologic department, City Clinical Hospital named after S.P. Botkin, Department of Health in Moscow.
Tel.: +7 (495) 677-16-11, natalie_sablina@yahoo.de
125284, Russia, Moscow, 2nd Botkinsky Prospect, 5.

For citation: Radzinsky V.E., Anufrieva V.G., Belinina A.A., Bespalaya A.V., Dolgushina V.F., Zhilno E.Yu., Zazerskaya I.E., Katkova N.Yu., Klimova O.I., Korotkikh I.N., Kravchenko E.N., Kutsenko I.G., Lebedenko E.Yu., Loseva V.V., Mingaleva N.V., Molchanova I.V., Ordiyants I.M., Padrul M.M., Pashov A.I., Protopopova N.V., Rosyuk E.A., Rymashevsky M.A., Sablina N.V., Salov I.A., Sokolova T.M., Spiridonova N.V.
Empirical therapy for vulvovaginitis in reproductive-aged women in routine clinical practice.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 2: 160-168. (In Russian).
https://dx.doi.org/10.18565/aig.2020.2.161-168

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