Extramammary Paget’s disease
Background: Extramammary Paget’s disease (EPD) is a rare tumor that most commonly affects the anogenital region. The foci often bear similarities to chronic dermatoses, which can make timely diagnosis difficult. A skin biopsy with histological and immunohistochemical studies is needed to verify the diagnosis of EPD. Most cases are treated with surgical resection, but the recurrence rate remains quite high.Grekova Yu.N., Zilberberg N.V., Kuznetsova E.I.
Case report: The paper describes a case of an EPD patient whose diagnosis was established 9 years after the onset of the disease.
Conclusion: Rare localization, prolonged course, resistance to previous therapy, and pronounced subjective sensations (itching and pain) necessitate a morphopathological study.
Keywords
extramammary Paget’s disease
vulva
clinical presentation
morphopathology
treatment
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Received 16.03.2022
Accepted 12.05.2022
About the Authors
Yulia N. Grekova, Dr. Med. Sci., Leading Researcher at the Department of Syphilidology and Sexually Transmitted Infections, Ural Research Institute of Dermatovenereology and Immunopathology, +7(908)630-26-00, kjn@mail.ru, https://orcid.org/0000-0001-7345-3068, 620076, Russia, Yekaterinburg, Shcherbakova str., 8.Natalya V. Zilberberg, Dr. Med. Sci., Professor, Deputy Director for Research, Ural Research Institute of Dermatovenereology and Immunopathology, +7(982)623-91-38, zilberberg@mail.ru, https://orcid.org/0000-0002-7407-7575, 620076, Russia, Yekaterinburg, Shcherbakova str., 8.
Ekaterina I. Kuznetsova, general practitioner, Verkhnepyshminskaya Central City Hospital named after P.D. Borodin, +7(908)630-30-01, kksk9@rambler.ru,
https://orcid.org/0000-0003-3785-7481, 624090, Russia, Sverdlovsk region, Verkhnyaya Pyshma, Tchaikovsky str., 32.
Corresponding author: Yulia N. Grekova, kjn@mail.ru
Authors' contributions: Grekova Yu.N., Kuznetsova E.I. – concept and design of the investigation, data collection and analysis and results interpretation, writing the article; Zilberberg N.V. – concept and design of the investigation, making a significant (important) correction to the manuscript in order to increase the scientific value of the article. All the authors have approved the final version of the article before publication, agreed to be responsible for all aspects of the work, which implies the proper study and resolution of issues related to the accuracy or good faith of any part of the work.
Conflicts of interest: The authors declare that there are no manifest and potential conflicts of interest related to the contents of this article.
Funding: The investigation has been conducted at the expense of planned research.
Ethical Approval: The investigation has been approved by the Ural Research Institute of Dermatovenereology and Immunopathology.
Patient Consent for Publication: The patient provided informed consent for the publication of her data and associated images.
For citation: Grekova Yu.N., Zilberberg N.V., Kuznetsova E.I. Extramammary Paget’s disease.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 6: 176-179 (in Russian)
https://dx.doi.org/10.18565/aig.2022.6.176-179
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