Biochemical tests for the diagnosis of premature rupture of membranes

Baev O.R., Dikke G.B.

1 National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia, Moscow; 2 F.I. Inozemtsev Academy of Medical Education, St. Petersburg, Russia
According to the results of clinical studies published in English-language and Russian literatures in open-access databases, the author has determined the importance and efficiency of biochemical tests for the diagnosis of premature rupture of membranes. Placental alpha microglobulin-1 (PAMG-1) has a lower detection limit of amniotic fluid than insulin-like growth factor binding protein-1 (IGFBP-1), with increased sensitivity (at 1:40 and 1:80 dilutions; p < 0.05), shorter response time, and better reproducibility (p < 0.05). The specificity and positive predictive value of PAMG-1 are considerably higher than those of IGFBP-1. The test kit for PAMG-1 is most effective, as compared to that for IGFBP-1, and can help avoid misdiagnosis and unnecessary hospitalization.

Keywords

premature rupture of membranes
fetal fibronectin (fFN)
insulin-like growth factor binding protein-1 (IGFBP-1)
placental alpha microglobulin-1 (PAMG-1)

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Received 08.06.2018

Accepted 22.06.2018

About the Authors

Baev, Oleg R., MD, professor, head of the maternity department, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named
after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381188. E-mail: o_baev@oparina4.ru
Dikke, Galina B., MD, Professor of the Department of Obstetrics and Gynecology with the course of reproductive medicine, F.I. Inozemtsev Academy of Medical Education. 190013, Russia, St. Petersburg, Moscow Ave, 22, letter M. Tel.: +78123347650. E-mail: galadikke@yandex.ru

For citations: Baev O.R., Dikke G.B. Biochemical tests for the diagnosis of premature rupture of membranes. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (9): 132-6. (in Russian)
https://dx.doi.org/10.18565/aig.2018.9.132-136

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