Diagnosis and topical therapy of lichen ruber planus in women
The term lichen ruber planus (LRP) is understood as a chronic inflammatory disease of the skin and mucous membranes, including the genitals, which is caused by CD8+ cytotoxic T lymphocytes. Despite the fact that the dermatosis was described more than 100 years ago, the exact causes of its development have not been identified to date. There is an increase in the number of cases of genital LRP concurrent with lichen sclerosus, focal neurodermatitis, atrophic vulvovaginitis, genitourinary syndrome, vulvar candidiasis, desquamative vaginitis, herpetic and papillomavirus infections. The review summarizes an update on the сlinical presentations of genital LRP, diagnosis, treatment approaches, drug dosage regimens, and its duration. Taking into account the fact that the pathogenesis of LRP is based on the formation of an inflammatory infiltrate, topical glucocorticosteroids are the drugs of choice for the treatment of LRP in the anogenital area.Chernova N.I., Maiorova E.M., Tapilskaya N.I., Novikova D.B., Atabieva A.Ya.
Conclusion: Genital LRP is a disease associated with a large number of causes and precipitating factors. Numerous studies have shown the efficiency of topical glucocorticosteroid therapy in combination with moisturizing and emollient agents. When properly administered and used, current topical corticosteroids are safe for patients with genital LRP.
Keywords
diagnosis
symptoms
local therapy
vulva
lichen ruber planus
corticosteroids
combined glucocorticosteroids
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Received 08.08.2022
Accepted 09.09.2022
About the Authors
Nadezhda I. Chernova, Dr. Med. Sci., Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, +7(499)558-58-28, d.chernova@mail.ru,https://orcid.org/0000-0002-4111-6670, 127473, Russia, Moscow, Seleznevskaya str., 20.
Elena M. Maiorova, Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, +7(499)558-58-28, eml20@mail.ru, Scopus Author ID 6603932226, ORCID 0000-0001-5942-6442, 127473, Russia, Moscow, Seleznevskaya str., 20.
Natalya I. Tapilskaya, Dr. Med. Sci., Professor, Professor at the Department of Obstetrics and Gynecology, Saint Petersburg State Pediatric Medical University,
Ministry of Health of Russia, +7(812)328-98-22, tapnatalia@yandex.ru, https://orcid.org/0000-0001-5309-0087, 194100, Russia, Saint Petersburg, Litovskaya str., 2.
Daria B. Novikova, Resident at the Department of Dermatology and Venereology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health
of Russia, +7(495)609-67-00, dari07@bk.ru, https://orcid.org/0000-0002-9264-1926, 127473, Russia, Moscow, Delegatskaya str., 20.
Aminat Ya. Atabieva, Junior Researcher, Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, amina-9308@mail.ru,
https://orcid.org/0000-0001-7467-7725, 127473, Russia, Moscow, Seleznevskaya str., 20.
Authors’ contributions: Chernova N.I. – selection of topics of the review; determination of its goals and objectives, material collection, writing the text; Maiorova E.M. – search for literature sources; Tapilskaya N.I., Atabieva A.Ya. – editing the text; Novikova D.B. – editing the references.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has not been sponsored.
Patient Consent for Publication: All patients provided informed consent for the publication of their data and associated images.
For citation: Chernova N.I., Maiorova E.M., Tapilskaya N.I., Novikova D.B., Atabieva A.Ya. Diagnosis and topical therapy of lichen ruber planus in women.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 12: 188-194 (in Russian)
https://dx.doi.org/10.18565/aig.2022.184
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