BRCA-associated breast cancer during pregnancy
Bakhova L.A., Shevlyukova T.P., Keln A.A., Shvedsky M.S., Mateykovich E.A., Nekrasova O.V., Shkuratova V.V., Karmaeva O.S.
Background: Breast cancer (BC) is the most common breast form diagnosed during pregnancy (from 1:3,000 to 1:10,000 cases) and is about 3% of all forms of BC. Physiological changes during pregnancy can hide the early signs of BC and, thereby, delay the diagnosis. When planning treatment during pregnancy, in each case, it is inevitable to discuss the gestation period, stage and form of BC. Case report: The paper describes a clinical case of a 28-year-old pregnant woman with malignant breast neoplasm diagnosed at 9.1 weeks’ gestation, with a family history, BRCA1 gene mutation, and HER2neи amplification. Due to the patient's refusal to terminate the pregnancy, resection of the left breast with a nodular mass and biopsy of the sentinel lymph node biopsy were performed. A postoperative histological examination confirmed high-grade invasive ductal carcinoma; no metastases were found in the distant lymph nodes. A consultation of doctors recommended adjuvant chemotherapy according to the AS regimen with an inter-cycle drug administration period of 21 days and subsequent targeted therapy with trastuzumab after delivery. Conclusion: The discussed case reflects the complexities of diagnosis and combination treatment in pregnant patients with BC.
Authors' contributions: Bakhova L.A., Nekrasova O.V., Shkuratova V.V. – writing and designing the manuscript; Shevlyukova T.P., Mateykovich E.A. – editing the manuscript; Shvedsky M.S. – analyzing the literature sources; writing the manuscript; Keln A.A., Karmaeva O.S. – finally editing the manuscript.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has not been sponsored.
Patient Consent for Publication: The female patient provided informed consent for the publication of their data and associated images.
For citation: Bakhova L.A., Shevlyukova T.P., Keln A.A., Shvedsky M.S., Mateykovich E.A., Nekrasova O.V., Shkuratova V.V., Karmaeva O.S. BRCA-associated breast cancer during pregnancy. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (10): 199-203 (in Russian) https://dx.doi.org/10.18565/aig.2023.97
Keywords
breast cancer
pregnancy
diagnosis
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Received 13.04.2023
Accepted 09.06.2023
About the Authors
Lilia A. Bakhova, Senior Lecturer, Department of Oncology, Radiology and Radiotherapy, Institute of Clinical Medicine, Tyumen State Medical University,Ministry of Health of Russia, lilya8913@mail.ru, eLibrary.Ru SPIN: 8832-3547, https://orcid.org/0000-0002-8918-6264, 625041, Russia, Tyumen, Barnaulskaya str., 32a.
Tatiana P. Shevlyukova, Dr. Med. Sci., Professor, Department of Obstetrics and Gynecology, Institute of Maternity and Childhood, Tyumen State Medical University,
Ministry of Health of Russia, tata21.01@mail.ru, eLibrary.Ru SPIN: 5035-7233, https://orcid.org/0000-0002-7019-6630, 625023, Russia, Tyumen, Odesskaya str., 54.
Artem A. Keln, PhD, Associate Professor, Department of Oncology, Radiology and Radiotherapy, Institute of Clinical Medicine, Tyumen State Medical University,
Ministry of Health of Russia, Artyom-keln@yandex.ru, eLibrary.Ru SPIN: 9633-0276, https://orcid.org/0000-0002-5071-0604, 625023, Russia, Tyumen, Odesskaya str., 54.
Maxim S. Shvedsky, 6th year student, Institute of Clinical Medicine, Tyumen State Medical University, Ministry of Health of Russia, Shvedsky99@gmail.com,
eLibrary.Ru SPIN: 2797-1965, https://orcid.org/0000-0002-8854-2773, 625023, Russia, Tyumen, Odesskaya str., 54.
Elena A. Mateykovich, PhD, Associate Professor, Department of Obstetrics and Gynecology, Director of the Institute of Maternity and Childhood, Tyumen State Medical University, Ministry of Health of Russia, mat-maxim@yandex.ru, eLibrary.Ru SPIN: 5864-8031, AuthorID: 744233, https://orcid.org/0000-0002-2612-7339,
625023, Russia, Tyumen, Odesskaya str., 54.
Oksana V. Nekrasova, Head of OPLT Department No. 2, ICMC Medical City, kuban.ksu@mail.ru, 32a Barnaulskaya St., Tyumen, 625032, Russia.
Vlada V. Shkuratova, doctor, OPLT No. 2, ICMC "Medical City", shkuratovavv@mail.ru, 625032, Russia, Tyumen, Barnaulskaya str., 32a.
Olga S. Karmaeva, Head of the Department of Molecular Genetics and Oncochemistry, Pathology Bureau, ICMC "Medical City", oskormina@mail.ru,
625032, Russia, Tyumen, Yury Semovskikh str., 12.
Corresponding author: Maxim S. Shvedsky, Shvedsky99@gmail.com
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