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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2025№6
Diagnosis of fetal central nervous...

Diagnosis of fetal central nervous system anomalies in the first trimester of pregnancy

DOI
https://dx.doi.org/10.18565/aig.2025.49

Talolinа O.V., Chugunova L.A., Gus A.I.

1) Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia; 2) Patrice Lumumba Peoples’ Friendship University of Russia, Moscow, Russia

Background: Early detection of central nervous system (CNS) anomalies is of great importance due to the substantial impact of such anomalies on the development of the CNS, often resulting in the onset of neuropsychiatric disability and cognitive impairment. Congenital pathology of CNS development is one of the main causes of perinatal and early infant mortality. Echographic evaluation of the CNS in the first trimester of pregnancy is extremely challenging due to the active development of brain structures during this period. However, scientific and technological progress in the last decade has expanded the diagnostic possibilities for obtaining new information about the characteristics and nature of pathological changes.
Objective: To analyze scientific publications reporting early detection of fetal CNS anomalies using volumetric ultrasound imaging.
Materials and methods: The literature search was performed in Scopus, Medline (PubMed), and eLibrary databases. The relevant sources were analyzed. Forty-seven scientific papers were used.
Results: The data on modern possibilities of ultrasonic diagnostics in the first trimester of pregnancy for early detection of fetal CNS anomalies were obtained.
Conclusion: The scientific literature highlights the clinical value and relevance of the development and implementation of expert multiparametric fetal neurosonography in the first trimester, according to the methodology recommended for specialised examination in the second trimester of pregnancy. The effectiveness of combining three-dimensional echography with genetic research methods and the application of machine analysis of echograms was confirmed.

Authors’ contributions: Talolina O.V. – developing the idea and concept of the study, collecting and analyzing literary data, writing the text; Chugunova L.A., Gus A.I. – developing the concept, analyzing literary data, editing the text.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was carried out without sponsorship.
For citation: Talolinа O.V., Chugunova L.A., Gus A.I. Diagnosis of 
fetal central nervous system anomalies in the first trimester of pregnancy.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (6): 5-12 (in Russian)
https://dx.doi.org/10.18565/aig.2025.49

Keywords

first trimester of pregnancy
CNS anomalies
neurosonography
three-dimensional echography
machine analysis of echograms
Full text (in Russian)

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Received 26.02.2025

Accepted 15.05.2025

About the Authors

Oksana V. Talolina, doctor-expert at the Department of Ultrasound and Functional Diagnostics, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4, +7(495)438-22-92, o_talolina@oparina4.ru, o.talolina@mail.ru,
https://orcid.org/0000-0001-8031-0962
Liliyana A. Chugunova, PhD, Senior Researcher at the Department of Ultrasound and Functional Diagnosis, Academician V.I. Kulakov National Medical Research Center
for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4, +7(495)438-22-92, l_chugunova@oparina4.ru
Aleksandr I. Gus, Dr. Med. Sci., Professor, Chief Researcher at the Department of Ultrasound and Functional Diagnostics, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4; Head of the Department of Ultrasound Diagnostics of the Faculty of Continuing Medical Education of the Medical Institute, Patrice Lumumba Peoples’ Friendship University of Russia,
+7(495)438-22-92, a_gus@oparina4.ru, https://orcid.org/0000-0003-1377-3128
Corresponding author: Oksana V. Talolinа, o.talolina@mail.ru

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