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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2024№11
Modern aspects of pathophysiology, diagnosis...

Modern aspects of pathophysiology, diagnosis and treatment of chronic endometritis

DOI
https://dx.doi.org/10.18565/aig.2024.223

Tabeeva G.I., Elovenko A.A., Dumanovskaya M.R., Asaturova A.V., Kuzemin A.A.

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia

Chronic endometritis is a chronic inflammatory disease of the endometrium characterized by the presence of plasma cells in the endometrial stroma.   The prevalence of this condition can vary, but its diagnosis presents significant challenges. These challenges are due to the non-specificity of its clinical symptoms, as well as the absence of unambiguous criteria for diagnosis. In addition, there is a lack of clinical guidelines in medical practice regarding the management of patients with this pathology. All these factors led to a detailed analysis of the currently available literature on chronic endometritis. This review provides key information that covers various aspects of this disease, including its etiology, pathogenesis, and approaches to diagnosis and treatment. The focus of this study is to examine the etiological factors of chronic endometritis. These include the colonization of various microorganisms and the release of endogenous molecules during endometrial trauma and ischemia. These factors lead to aberrant activation of innate immunity, alteration of immunocompetent cells, and increased production and release of inflammatory cytokines. The article presents the findings of studies conducted to evaluate the efficacy of various antibiotic regimens in the treatment of chronic endometritis. The results of other treatments, such as intrauterine infusion of autologous platelet-rich plasma and the use of lactoferrin, are also described. The review pays special attention to the current literature data on molecular biological markers (inflammasomes, extracellular vesicles, etc.) that play an important role in the pathogenesis of the disease. These markers have the potential to be promising tools for the diagnosis of chronic endometritis and the development of innovative therapeutic approaches in the future.
Conclusion: This review highlights the need to study chronic endometritis and its molecular mechanisms, which may open new horizons to improve the diagnosis and treatment of this pathological condition.

Authors’ contributions: Tabeeva G.I. – developing the concept and design of the review; Tabeeva G.I., Elovenko A.A. – writing the text; Dumanovskaya M.R., Asaturova A.V., Kuzemin A.A. – editing the article.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was carried out within the framework of State Assignment to the Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology (№122020900122-7).
For citation: Tabeeva G.I., Elovenko A.A., Dumanovskaya M.R., Asaturova A.V., Kuzemin A.A. 
Modern aspects of pathophysiology, diagnosis and treatment of chronic endometritis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (11): 12-20 (in Russian)
https://dx.doi.org/10.18565/aig.2024.223

Keywords

chronic endometritis
plasma cell
endometrium
hysteroscopy
histological study
immunohistochemistry
Full text (in Russian)

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Received 06.09.2024

Accepted 29.10.2024

About the Authors

Gyuzyal I. Tabeeva, PhD, Senior Researcher, Department of Gynecological Endocrinology, V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 4, Oparina str., Moscow, 117997, Russia, +7(903)199-72-82, g_tabeeva@oparina4.ru, https://orcid.org/0000-0003-1498-6520
Alina A. Elovenko, Resident, V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia,
4, Oparina str., Moscow, 117997, Russia, alina.elovenko@gmail.com
Madina R. Dumanovskaya, PhD, Senior Researcher, Department of Gynecological Endocrinology, V.I. Kulakov National Medical Research Center of Obstetrics,
Gynecology and Perinatology, Ministry of Health of Russia, 4, Oparina str., Moscow, 117997, Russia, dumanovskaya@gmail.com, https://orcid.org/0000-0001-7286-6047
Alexandra V. Asaturova, Dr. Med. Sci., Head of the 1st Pathological Anatomy Department, V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 4, Oparina str., Moscow, 117997, Russia, a_asaturova@oparina4.ru, https://orcid.org/0000-0001-8739-5209
Andrey A. Kuzemin, PhD, Head of the Day Hospital, V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 4, Oparina str., Moscow, 117997, Russia, a_kuzemin@oparina4.ru, https://orcid.org/0000-0002-7559-0629
Corresponding author: Gyuzyal I. Tabeeva, g_tabeeva@oparina4.ru

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