Asymptomatic bacteriuria in pregnancy: a modern approach to therapy
Objective: To evaluate the efficiency of combination therapy for asymptomatic bacteriuria in pregnant women, its impact on pregnancy outcomes and the course of the perinatal period.Tyutyunnik V.L., Mikhailova O.I., Kan N.E., Mirzabekova D.D.
Materials and methods: The clinical study involved 44 patients who had experienced an episode of asymptomatic bacteriuria in the first trimester of pregnancy. There were two equal groups: a study group of 22 women who received therapy with antibacterial and immunomodulatory drugs and a comparison group of 22 patients who had monotherapy with an antibacterial drug. The efficiency of different treatment regimens for asymptomatic bacteriuria was evaluated, by analyzing the results of laboratory tests, such as clinical urinalysis and urine microbiological examination; the duration of a relapse and an interval between exacerbations; and the course of labor and perinatal outcomes.
Results: The patients treated with a combination of an antibacterial drug and an immunomodulatory agent for asymptomatic bacteriuria in pregnancy had the best therapy results. This was confirmed by a considerable reduction in the growth of pathogenic microorganisms during microbiological examination, a substantially longer interval between relapses, and a decrease in their duration. The study group showed the most favorable obstetric and perinatal outcomes.
Conclusion: The immunomodulator Superlymph can be recommended for use in combination with an antibacterial drug in the treatment of asymptomatic bacteriuria in pregnant women. In the authors’ opinion, this combination is effective in achieve a high therapeutic effect.
Keywords
asymptomatic bacteriuria
pregnancy
immunomodulatory therapy
Superlymph
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Received 28.10.2022
Accepted 03.11.2022
About the Authors
Victor L. Tyutyunnik, Professor, MD, PhD, Leading Researcher at the Center for Scientific and Clinical Research, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(903)969-50-41, tioutiounnik@mail.ru, Researcher ID: B-2364-2015, SPIN-код: 1963-1359, Authors ID: 213217, Scopus Author ID: 56190621500, https://orcid.org/0000-0002-5830-5099, 117997, Russia, Moscow, Ac. Oparina str., 4.Olga I. Mikhailova, PhD, Researcher, 1 Maternity Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(926)564-68-13, omikhaylova@gmail.com, https://orcid.org/0000-0001-7569-8704, 117997, Russia, Moscow, Ac. Oparina str., 4.
Natalia E. Kan, Professor, MD, PhD, Deputy Director of Science, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(926)220-86-55, kan-med@mail.ru, Researcher ID: B-2370-2015, SPIN-код: 5378-8437, Authors ID: 624900,
Scopus Author ID: 57008835600, https://orcid.org/0000-0001-5087-5946, 117997, Russia, Moscow, Ac. Oparina str., 4.
Dzhamilia D. Mirzabekova, graduate student, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health
of Russia, +7(906)110-51-13, +7(920)984-94-07, Jamilya1705@yandex.ru, https://orcid.org/0000-0002-2391-3334, 117997, Russia, Moscow, Ac. Oparina str., 4.
Authors’ contributions: Tyutyunnik V.L., Mikhailova O.I., Kan N.E., Mirzabekova D.D. – development of the design of the investigation, obtaining the data to be analyzed, reviewing publications on the topic of the article, statistical analysis of the findings, writing the text of the manuscript.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation has not been sponsored.
Ethical Approval: The investigation has been approved by the Ethics Committee, V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors’ Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Tyutyunnik V.L., Mikhailova O.I., Kan N.E., Mirzabekova D.D. Asymptomatic bacteriuria in pregnancy: a modern approach to therapy.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 11: 165-170 (in Russian)
http://dx.doi.org/10.18565/aig.2022.11.165-170
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