Adenomyosis: from scientific discoveries to the practical aspects of prescribing drug therapy

Yarmolinskaya M.I., Shalina M.A., Khachaturyan A.R., Netreba E.A., Florova M.S., Mekhtikhanova S.V.

1) D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, Saint Petersburg, Russia; 2) I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg, Russia; 3) Saint Petersburg State University, Saint Petersburg, Russia
Objective. To assess and analyze the results of 6-68-month treatment with dienogest 2 mg in patients with adenomyosis.
Subjects and methods. Sixty-two reproductive-aged patients diagnosed with adenomyosis received therapy with dienogest 2 mg for 6 months, of whom 24.2% continued to take the drug for a longer period.
Results. Diffuse adenomyosis was observed in most (87.1%) patients; focal or nodular adenomyosis was seen in 24.2% of patients. During a 6-month dienogest treatment cycle, 53.4% of patients showed a decrease in pain intensity, 31% had complete pain relief; 70.7% of patients had significant uterine volume reduction. All the patients were noted to have a decrease in the intensity, frequency, and duration of bloody vaginal discharge.
Conclusion. The authors’ own studies have established that the use of dienogest eliminates pain and abnormal uterine bleeding and decreases uterine volume in most patients. The therapy is characterized by good tolerance and can be used for a long time.

Keywords

adenomyosis
genital endometriosis
signaling pathways
dienogest
treatment of adenomyosis

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Received 06.02.2020

Accepted 07.02.2020

About the Authors

Maria I. Yarmolinskaya, professor of Russian Academy of Sciences, Doctor of medical sciences, professor, head of department of gynecology and endocrinology, head of center Diagnostics and treatment of endometriosis FSBSI The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott; professor at the Department of obstetrics and gynecology North-Western state medical University named after I.I. Mechnikov. e-mail: m.yarmolinskaya@gmail.com.
https://orcid.org/0000-0002-6551-4147
Address: 199034, Russian Federation, Saint-Petersburg, Mendeleevskaya liniya, 3.
Maria A. Shalina, Phd, senior researcher of Department Gynecology and Endocrinology, Head of the Center «Menopause and Women’s Health». FSBSI The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott. e-mail: amarus@inbox.ru. https://orcid.org/0000-0002-5921-3217
Address: 199034, Russian Federation, Saint-Petersburg, Mendeleevskaya liniya, 3.
Armine R.Khachaturian, PhD, senior researcher of the department of gynecology and endocrinology, FSBSI The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott, associate professor of the department of obstetrics, gynecology and reproductology. e-mail: armine2709@mail.ru,
https://orcid.org/0000-0003-2141-6307
Address: 199034, Russian Federation, Saint-Petersburg, Mendeleevskaya liniya, 3.
Elena A. Netreba, resident physician of the FSBSI The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott.
E-mail: dr.netlenka@yandex.ru. https://orcid.org/0000-0002-0485-3612
Address: 199034, Russian Federation, Saint-Petersburg, Mendeleevskaya liniya, 3.
Margarita S. Florova, junior researcher of the department of gynecology and endocrinology, FSBSI The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott. E-mail: fm.sergeevna@gmail.com https://orcid.org/0000-0003-4569-3827
Address: 199034, Russian Federation, Saint-Petersburg, Mendeleevskaya liniya, 3.
Svetlana V. Mehtihanova, resident physician of the FSBSI The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott.
E-mail: svetlana-demb@mail.ru. Address: 199034, Russian Federation, Saint-Petersburg, Mendeleevskaya liniya, 3.

For citation: Yarmolinskaya M.I., Shalina M.A., Khachaturyan A.R., Netreba E.A., Florova M.S., Mekhtikhanova S.V. Adenomyosis: from scientific discoveries to the practical aspects of prescribing drug therapy.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 3: 182-190. (In Russian).
https://dx.doi.org/10.18565/aig.2020.3.182-190

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