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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2026№4

Possibilities for the risk prediction of severe locomotive syndrome in 50–60-year-old women with climacteric syndrome

DOI
https://dx.doi.org/10.18565/aig.2026.117

Dobrokhotova Yu.E., Khashukoeva A.Z., Naumov A.V., Nosova L.A., Proskuryakova A.S., Kuznetsov D.A.

1) Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia; 2) Russian Gerontological Scientific and Clinical Center, Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Rationale: Ageing of population makes maintaining mobility in postmenopausal women a public health priority. Locomotive syndrome (LS) is known to be an integrated indicator of locomotor system disorders, which is found in 88% of women during this period. Existing tools (FRAX, SARC-F) assess bone or muscle tissue separately, disregarding the pathogenetic link between menopause and locomotor disorders.
Objective: To develop a prognostic model for the risk assessment of severe mobility impairments in musculoskeletal diseases in women with climacteric syndrome (CS).
Materials and methods: The study included 180 patients with CS aged 50–60. We conducted CS and LS severity assessment along with a comprehensive examination: GLFS-25, REMS densitometry, and bioimpedance analysis. A classification tree method was used to construct the model, ensuring the interpretability of risk classes. To assess the quality, we used ROC analysis (AUC, sensitivity, specificity).
Results: Stage III LS was detected in 24.4% of women. We identified six risk classes with the risk for severe mobility impairments development ranging from 3.5 to 66.7%. The extremely high-risk group (66.7%) is associated with a combination of moderate CS severity, postmenopausal duration ≥5 years, and a decrease in the REMS T-score < -1.5. Unlike FRAX, which assesses fracture risk, the model predicts the risk of functional loss (stage III LS) (AUC=0.82), which clinical significance appears earlier than that of a fracture. 
Conclusion: For the first time, a model has been developed that combines the severity of cesarean section, clinical and history data, and musculoskeletal parameters to predict the risk of locomotor autonomy loss. The model allows gynecologists to perform screening in an outpatient setting.

Authors’ contributions: Dobrokhotova Yu.E., Khashukoeva A.Z., Naumov A.V., Nosova L.A. – study concept and design; Nosova L.A., Proskuryakova A.S., Kuznetsov A.D. – material collection and processing, data statistical processing; Khashukoeva A.Z., Nosova L.A. – manuscript conduction; Dobrokhotova Yu.E., Khashukoeva A.Z., Naumov A.V. – manuscript editing.
Conflicts of interest: The authors declare no possible conflict of interests.
Funding: The study had no financial support. 
Ethical Approval: The study was approved by the independent Ethics Committee of the Pirogov Russian National Research Medical University, Ministry of Health of Russia (Protocol No. 213 of December 13, 2021).
Patient Consent for Publication: The patients signed informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Dobrokhotova Yu.E., Khashukoeva A.Z., Naumov A.V., Nosova L.A., Proskuryakova A.S., Kuznetsov D.A. Possibilities for the risk prediction of severe locomotive syndrome in 50–60-year-old women with climacteric syndrome. 
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (4): 134-142 (in Russian)
https://dx.doi.org/10.18565/aig.2026.117

Keywords

climacteric syndrome
menopause
locomotive syndrome
osteoporosis
osteoarthritis
sarcopenia
Full text (in Russian)

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Received 08.04.2026

Accepted 23.04.2026

About the Authors

Yulia E. Dobrokhotova, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Institute of Surgery, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 117997, Russia, Moscow, Ostrovityanova str., 1, pr.dobrohotova@mail.ru, https://orcid.org/0000-0002-7830-2290
Asiyat Z. Khashukoeva, Dr. Med. Sci., Professor, Professor at the Department of Obstetrics and Gynecology, Institute of Surgery, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 117997, Russia, Moscow, Ostrovityanova str., 1; obstetrician-gynecologist, Russian Gerontological Research and Clinical Center, 129226, Russia, Moscow, 1st Leonova str., 16, azk05@mail.ru, https://orcid.org/0000-0001-7591-6281
Anton V. Naumov, Dr. Med. Sci., Professor at the Department of Diseases of Aging, Faculty of Additional Professional Education, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 117997, Russia, Moscow, Ostrovityanova str., 1; Head of the Laboratory of Diseases of the Musculoskeletal System, Russian Gerontological Research and Clinical Center, 129226, Russia, Moscow, 1st Leonova str., 16, nanton@mail.ru, https://orcid.org/0000-0002-6253-621X
Lilia A. Nosova, Teaching Assistant at the Department of Obstetrics and Gynecology, Institute of Surgery, Pirogov Russian National Research Medical University,
Ministry of Health of Russia, 117997, Moscow, Ostrovityanova str., 1, karelina_lilia@mail.ru, https://orcid.org/0000-0002-0925-3755
Arina S. Proskuryakova, Student, Medical Faculty, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 117997, Moscow, Ostrovityanova str., 1, 2368618al@mail.ru, https://orcid.org/0009-0004-6128-8420
Dmitriy A. Kuznetsov, Resident at the Department of Obstetrics and Gynecology, Institute of Surgery, Pirogov Russian National Research Medical University,
Ministry of Health of Russia, 117997, Moscow, Ostrovityanova str., 1, kda7117@yandex.ru, https://orcid.org/0009-0003-9230-1109
Corresponding author: Asiyat Z. Khashukoeva, azk05@mail.ru

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