Study the modifying effect of obesity on uterine fibroid’s clinical characteristics in Syrian women
Alali O.M., Churnosov M.I.
Objective: To evaluate the modifying effect of obesity on clinical manifestations of uterine fibroids (UF) in Syrian women.
Materials and methods: 1,000 Syrian women, ages 22–83, from different cities participated in the study, which ran from June 2023 to August 2024. They were divided based on obesity and disease into two groups: with obesity BMI ≥30 kg/m2 (160 patients and 146 controls), and without obesity BMI <30 kg/m2 (340 patients and 354 controls). The study employed a questionnaire consisting of 65 items that provided information on the clinical features and risk factors for the development of UF. Version 30 of SPSS was used to analyze data.
Results: Revealed the features of the clinical characteristics of the non-obese group that were statistically significant in patients compared to controls: an older age, a shorter menstrual cycle length and a lower rate of endometrial ablation, and didn't reveal specific features in the obese group. In both studied groups, obese and non-obese, in patients compared to controls, the age of menopause was earlier, and by the time elapsed since the last birth, the percentage was lower in the categories: ≤5 years and 11–15 years, while within the categories: 6–10 years, 16–19 years, and ≥20 years, it was higher.
Conclusion: This study demonstrated the modifying effect of obesity on clinical manifestations of UF in Syrian women. That will provide additional clarification of the impact of obesity on the risk/prevalence of UF, which will be beneficial for both its prevention and diagnosis.
Authors' contributions: Alali O.M., Churnosov M.I. – conception and design of the study; Alali O.M. – data collection and analysis, manuscript drafting; Churnosov M.I. – manuscript editing.
Conflicts of interest: The authors have no conflicts of interest to declare.
Funding: There was no funding for this study.
Ethical Approval: The study was reviewed and approved by the Research Ethics Committee of the Belgorod State National Research University.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available upon request from the corresponding author after approval from the principal investigator.
For citation: Alali O.M., Churnosov M.I. Study the modifying effect of obesity on
uterine fibroid’s clinical characteristics in Syrian women.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (11): 120-128 (in Russian)
https://dx.doi.org/10.18565/aig.2025.193
Keywords
uterine fibroid
leiomyoma
body mass index
obesity
overweight
risk factor
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Received 15.07.2025
Accepted 15.10.2025
About the Authors
Ola Mohamad Alali, PhD student, Homs, Syria, Belgorod State National Research University, Belgorod, Russia, alali@bsuedu.ru, https://orcid.org/0000-0003-4370-6719Mikhail I. Churnosov, Dr. Med. Sci., Professor, Belgorod State National Research University, Belgorod, Russia, churnosov@bsuedu.ru, https://orcid.org/0000-0003-1254-6134
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