Modern methods of treatment and prevention of pelvic inflammatory diseases

DOI

https://dx.doi.org/10.18565/aig.2025.337

Khashukoeva A.Z., Markova E.A., Burdenko M.V., Khashukoeva I.Z., Proskuryakova A.S.
1) N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia; 2) H.M. Berbekov Kabardino-Balkarian State University, Nalchik, Russia

Pelvic inflammatory diseases (PID), including endometritis, salpingitis, oophoritis, tubo-ovarian abscess, and pelvioperitonitis, can cause a wide range of problems in women of reproductive age. These conditions can significantly affect reproductive outcomes later in life. The need for gynecologists to pay close attention to the problem of pelvic inflammatory disease (PID) is associated not only with the possibility of severe complications that require urgent surgical intervention, but also with complex, multi-component, and expensive treatment regimens. Additionally, there are obvious risks of long-term undesirable consequences, such as infertility. The assessment of our ability to help patients with these conditions is the focus of today’s discussion.
Objective: To conduct a review of literature on the effectiveness of complex therapy with broad-spectrum antibiotics and to consider relevant strategies for preventing the development of PID.
Materials and methods: A literature review of published sources on the pharmacotherapy of PID over the past decade was conducted using the PubMed database.
Results: Combination therapy with tetracycline-type drugs (Doxycycline EXPRESS) in instant form and suppositories for vaginal administration containing benzyldimethyl-myristoylamino-propylammonium (Miramistin) shows high clinical efficacy in the treatment and prevention of PID of both specific and non-specific etiology.
Conclusion: Rational pharmacotherapy for inflammatory processes in the pelvic organs using drugs with proven effectiveness will lead to a rapid and positive clinical outcome in the treatment of patients with PID of different etiologies, providing a favorable prognosis and giving hope for the restoration of reproductive function, even in patients with tubo-peritoneal infertility.

Authors' contributions: Khashukoeva A.Z., Markova E.A., Burdenko M.V. – developing the concept and design of the study; Khashukoeva I.Z., Proskuryakova A.S. – collecting and processing the material; Khashukoeva A.Z., Markova E.A. – writing the text; Khashukoeva A.Z. – editing the article.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was conducted without sponsorship.
For citation: Khashukoeva A.Z., Markova E.A., Burdenko M.V., Khashukoeva I.Z., Proskuryakova A.S.
Modern methods of treatment and prevention of pelvic inflammatory diseases.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (12): 19-26 (in Russian)
https://dx.doi.org/10.18565/aig.2025.337

pelvic inflammatory diseases

PID

antibacterial therapy

broad-spectrum antibiotic

doxycycline

Doxycycline EXPRESS

antiseptic

benzyldimethyl-myristoilamine-propylammonium

Miramistin

sexually transmitted infections

infertility

Full text (in Russian)

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Received 17.11.2025

Accepted 09.12.2025

Asiyat Z. Khashukoeva, Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology of the Institute of Surgery, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 129226, Russia, Moscow, 1st Leonova str., 16, +7(499)187-12-54, azk05@mail.ru, https://orcid.org/0000-0001-7591-6281
Eleonora A. Markova, PhD, Assistant at the Department of Obstetrics and Gynecology of the Institute of Surgery, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 105187, Russia, Moscow, Fortunatovskaya str., 1, +7(499)166-97-41, +7(915)275-25-60, markova.eleonora@mail.ru,
https://orcid.org/0000-0002-9491-9303
Marina V. Burdenko, PhD, Associate Professor at the Department of Obstetrics and Gynecology of the Institute of Surgery, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 105187, Russia, Moscow, Fortunatovskaya str., 1, +7(499)166-97-41, +7(925)248-16-16, bmv-0306@rambler.ru,
https://orcid.org/0000-0002-0304-4901
Ilona Z. Khashukoeva, student at Medical Academy, H.M. Berbekov Kabardino-Balkarian State University, Nalchik, Russia, +7(905)436-11-51, ilona_1017@mail.ru,
https://orcid.org/0009-0000-4378-910X
Arina S. Proskuryakova, student, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 105187, Russia, Moscow, Fortunatovskaya str., 1, +7(916)236-86-18, 2368618al@mail.ru, https://orcid.org/0009-0004-6128-8420

Modern methods of treatment and prevention of pelvic inflammatory diseases

Khashukoeva A.Z., Markova E.A., Burdenko M.V., Khashukoeva I.Z., Proskuryakova A.S.

Keywords

References

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