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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
ArchiveEthical StandardsSubscription
For authors
InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
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Obstetrics and Gynegology2025№12

Association between extradiol and progesterone levels and chronic endometritis in women with reproductive disorders

DOI
https://dx.doi.org/10.18565/aig.2025.225

Ievleva K.D., Danusevich I.N., Sholokhov L.F., Suturina L.V., Kolesnikova L.I.

1) Scientific Center of Family Health Problems and Human Reproduction, Irkutsk, Russia; 2) Irkutsk State University, Irkutsk, Russia

Objective: To identify between and progesterone levels and chronic endometritis (CE) in women with reproductive disorders.
Materials and methods: A retrospective analysis of data that were obtained in the previously conducted study involving the patients with miscarriage/infertility, who had CE (n=49) or had no CE (n=42), and 24 healthy women, was performed. All patients underwent general and gynecological examination, pelvic ultrasound, endometrial pipelle biopsy for pathomorphological assessment of the endometrial samples. The diagnostic tests for serum levels of estradiol and progesterone were performed. The levels of pro-inflammatory and anti-inflammatory cytokines in endometrial samples were detected. 
Results: Serum estradiol concentrations and estradiol/progesterone (E/P) ratio were higher, and progesterone levels were lower, as well the levels of IL-1, IL-6, IL-4, IL-8, TNF-α, and IFN-γ in endometrial cells were higher in patients with CE and miscarriage/infertility compared with healthy women. In patients with miscarriage/infertility, and without CE, serum progesterone levels were lower, and the levels of IL-6, IL-8, IL-10 and TNF-α in endometrial cells were higher compared with healthy women. It was found that with increased E/P ratio, the risk of chronic endometritis was by 1,5 times higher in women with miscarriage/infertility compared with healthy women (OR 1.525; 95% CI 1.247–2.026).  
Conclusion: Without regard to the presence or absence of CE, there was an imbalance in steroid hormone concentrations in the blood and cytokines in the endometrium in the patients with miscarriage/infertility, and it was severe in the presence of CE. The patients with miscarriage/infertility, and with a  high E/P ratio, had a higher risk of developing CE.

Authors' contributions: Ievleva K.D. – the concept of the study, statistical data processing, manuscript writing; Danusevich I.N. – the concept of the study, manuscript; Sholokhov L.F., Suturina L.V., Kolesnikova L.I. – manuscript editing. 
Conflicts of interest: The authors confirm that they have no conflict of interest to declare.
Funding: The study was conducted within the framework of the State budgetary task on the topic “Pathophysiological mechanisms and genetic and metabolic predictors for maintaining reproductive health and longevity in different age, gender, and ethnic groups” (FGMZ-2021-0002).
Ethical Approval: The study was approved by the local Ethics Committee of the Scientific Center of Family Health Problems and Human Reproduction.
Patient Consent for Publication: The patients have signed informed consent publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Ievleva K.D., Danusevich I.N., Sholokhov L.F., Suturina L.V., Kolesnikova L.I. Association
between extradiol and progesterone levels and chronic endometritis in women with reproductive disorders.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (12): 88-96 (in Russian)
https://dx.doi.org/10.18565/aig.2025.225

Keywords

miscarriage
infertility
chronic endometritis
estradiol
progesterone
cytokines
Full text (in Russian)

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Received 21.08.2025

Accepted 26.11.2025

About the Authors

Kseniia D. Ievleva, PhD, Researcher at the Laboratory of Gynecological Endocrinology, Scientific Center for Family Health and Human Reproduction Problems,
664003, Russia, Irkutsk, Timiryazev str., 16, +7(3952)20-76-36, asiy91@mail.ru, https://orcid.org/0000-0002-0177-234X
Irina N. Danusevich, Dr. Med. Sci., Head of the Laboratory of Gynecological Endocrinology, Scientific Center for Family Health and Human Reproduction Problems,
664003, Russia, Irkutsk, Timiryazev str., 16, +7(3952)20-76-36, irinaemails@gmail.com, https://orcid.org/0000-0002-8862-5771
Leonid F. Sholokhov, Dr. Med. Sci., Professor, Head of the Laboratory of Physiology and Pathology of Endocrine System, Scientific Center for Family Health and Human Reproduction Problems, 664003, Russia, Irkutsk, Timiryazev str., 16, +7(3952)20-76-36, lfshol@mail.ru, https://orcid.org/0000-0003-3588-6545
Larisa V. Suturina, Dr. Med. Sci., Professor, Head of the Department of Reproductive Health Protection, Scientific Center for Family Health and Human Reproduction Problems, 664003, Russia, Irkutsk, Timiryazev str., 16, +7(3952)20-76-36, lsuturina@mail.ru, https://orcid.org/0000-0002-6271-7803
Lubov I. Kolesnikova, Academician of the RAS, Dr. Med. Sci., Professor, Scientific Supervisor, Scientific Center for Family Health and Human Reproduction Problems,
664003, Russia, Irkutsk, Timiryazev str., 16; Professor at the Department of Physiology and Psychophysiology, Irkutsk State University, +7(3952)20-76-36, iphr@sbamsr.irk.ru, https://orcid.org/0000-0003-3354-2992
Corresponding author: Kseniia D. Ievleva, asiy91@mail.ru

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