Non-hormonal methods of climacteric syndrome correction: the effectiveness of “Mabelle Plus” complex in the clinical practice according to the results of “Mirabella” observational study
Apolikhina I.A., Boris D.A.
Objective. To evaluate the effect of the "Mabelle Plus" dietary supplement on the climacteric symptoms change, given the stage of aging of the reproductive system according to the STRAW+10 scale over 6 months.
Materials and methods. A non-interventional prospective study was conducted including 50 patients aged 45–60 years (diagnosis N95.1) with vasomotor and other mild/moderate climacteric symptoms. Patients in the main group (n=25) received Mabell Plus (1 tab. 3 times a day), in the comparison group (n=25) – red clover isoflavones (1 capsule 3 times a day) for 6 months. Efficacy and safety were assessed at 1 and 6 months by the dynamics of hot flashes, the severity of climacteric syndrome (according to the Green Climacteric Scale), the vaginal health index (VHI), body mass index (BMI), and the absence of adverse reactions.
Results. The groups were comparable in age and anthropometry. The main group had a higher initial total Green scale score (25.80 vs. 18.40; p=0.0057). After 2 days, a decrease in the number of hot flushes was noted in this group, and after 30 days, a statistically significant decrease in the number of hot flushes was recorded (-3.04 vs. -1.67; p<0.05); after 6 months, there was a significant improvement on the Green scale: the overall score decreased by 20.72 (vs. -4.76 in the comparison group; p<0.00001), complaints of sleep disorders disappeared, vasomotor manifestations decreased by 3 times, and mood improved. BMI decreased (-0.61 vs. +0.04; p<0.05) and VHI improved (+4.88 vs. +1.08; p<0.00001). No adverse reactions were registrated.
Conclusion. The use of the Mabell Plus complex in peri- and postmenopausal women provided a significant decrease in the frequency of hot flashes and the severity of climacteric syndrome, normalization of sleep, improved vaginal health and a decrease in BMI. Mabelle Plus has a favorable safety profile and can be considered as an effective non-hormonal alternative in patients with climacteric manifestations and contraindications to menopausal hormonal therapy or when non-hormonal methods are preferred.
Authors' contributions. Boris D.A., Apolikhina I.A. – study design, obtaining data for analysis, review of publications with regard to the article, manuscript writing.
Conflicts of interest. The authors declare no possible conflict of interests.
Funding. The publication of the article is supported by AO Nizhfarm. Authors’ opinion may differ from the opinion of the Company.
Use of generative artificial intelligence. While conducting the manuscript, the authors used an artificial intelligence tool (DeepSeek) for stylistic editing and paraphrasing of individual text fragments. The final editing of the manuscript and responsibility for the content rest fully with the authors. No key scientific data, results, or conclusions were generated using AI.
Patient Consent for Publication. All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement. The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Apolikhina I.A., Boris D.A. Non-hormonal methods of climacteric syndrome correction: the effectiveness of “Mabelle Plus” complex in the clinical practice according to the results of “Mirabella” observational study.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (5): 165-173 (in Russian)
https://dx.doi.org/10.18565/aig.2026.155
Keywords
climacteric syndrome
menopause
non-hormonal therapy
phytoestrogens
beta-alanine
hot flashes
sleep disorders
Mabelle Plus
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Received 05.05.2026
Accepted 22.05.2026
About the Authors
Inna A. Apolikhina, Dr. Med. Sci., Professor, Head of the Department of Aesthetic Gynecology and Rehabilitation, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4; Professor, Department of Obstetrics, Gynecology, Perinatology and Reproductology, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), i_apolikhina@oparina4.ru,SPIN: 6282-7435, https://orcid.org/0000-0002-4581-6295
Daiana A. Boris, PhD, obstetrician-gynecologist, doctor of ultrasound diagnostics, Senior Researcher at the Department of Aesthetic Gynecology and Rehabilitation, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia,
117997, Russia, Moscow, Ac. Oparin str., 4, dayana_boris@mail.ru, SPIN: 4832-0643, https://orcid.org/0000-0002-0387-4040
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