Diagnostic and predictive significance of standardized placental weight and birth weight percentiles for gestational age
Rodionov V.E., Zarubin E.A., Nichiporov A.I., Tiumeneva E.A., Chernov I.A., Kirillov Yu.A.
Objective. To develop gender-specific distribution of placental weight percentiles based on newborn’s birth weight and gestational age, perform preliminary analysis of influencing factors and assess the possibility of using these percentiles as regional standards.
Materials and methods. A retrospective analysis of 2039 cases of singleton pregnancy was performed. The following parameters were analyzed: newborn’s weight and height, placental weight, newborn’s gender, gestational age, maternal age and weight, parity. The Kolmogorov–Smirnov test was used to check the quantitative variables for normal distribution. The Mann–Whitney U test was used to compare independent groups. Spearman’s rank correlation coefficient was used to assess the strength of relationship between two ranked variables. The main product of the study consists of percentile standards, which were calculated using statistical modeling.
Results. The median weight of newborns was 3450 g (interquartile range (IQR) 3060–3860 g). The median gestational age was 39 weeks (IQR 38–40 weeks). Correlation analysis confirmed strong relationship between newborn’s weight and height (ρ=0.901; p<0.001), as well as between newborn’s weight and placental weight (ρ=0.716; p<0.001). As a result of statistical modeling, the tables of percentiles were created (the 3rd, 10th, 50th, 90 and 97th percentiles) reflecting distribution of placental weight based on newborn’s weight and gestational age.
Conclusion. The developed gender-specific standardized placental weight percentiles represent an instrument for standardized placental assessment. Implementation of standardized placental weight percentiles into clinical practice will contribute to more objective diagnostics, improve early detection of risks associated with placental dysfunction, and provide improved personalized approach to management of pregnancy.
Authors' contributions. Rodionov V.E., Kirillov Yu.A., Chernov I.A. – the study concept and design; Rodionov V.E., Zarubin E.A., Nichiporov A.I., Tiumeneva E.A. – material collection and processing; Rodionov V.E. – statistical data processing; Rodionov V.E., Kirillov Yu.A. – manuscript writing; Zarubin E.A., Kirillov Yu.A., Chernov I.A. – manuscript editing.
Conflicts of interest. The authors have no conflicts of interest to declare that are related to publication of this article.
Funding. The study was carried out without any sponsorship.
Ethical Approval. The study was approved by the local Ethics Committee of Moscow Multidisciplinary Clinical Center “Kommunarka” of Moscow Healthcare Department (protocol No. 6 of August 08, 2023).
Authors' Data Sharing Statement. The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Rodionov V.E., Zarubin E.A., Nichiporov A.I., Tiumeneva E.A., Chernov I.A., Kirillov Yu.A. Diagnostic and predictive significance of standardized placental weight and birth weight percentiles for gestational age.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (5): 71-77 (in Russian)
https://dx.doi.org/10.18565/aig.2026.32
Keywords
placental weight
fetal weight
newborn’s weight
fetal length
newborn’s height
standardized percentiles
placental morphometry
prenatal diagnosis
placenta
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Received 02.02.2026
Accepted 09.04.2026
About the Authors
Vladimir E. Rodionov, Pathologist, Moscow Multidisciplinary Clinical Center «Kommunarka», Moscow City Healthcare Department, 108814, Russia, Moscow,Sosenskoye village, Kommunarka village, Sosensky Stan str., 8, build. 3, TiNAO; Lecturer at the Department of Pathological Anatomy and Forensic Medicine, Tyumen State Medical University, Ministry of Health of Russia, 625023, Russia, Tyumen, Odesskaya str., 54, +7(916)323-88-24, rodionov.ve@mail.ru, https://orcid.org/0000-0003-0842-4169
Egor A. Zarubin, PhD, Pathologist, Moscow Multidisciplinary Clinical Center «Kommunarka», Moscow City Healthcare Department, 108814, Russia, Moscow,
Sosenskoye village, Kommunarka village, Sosensky Stan str., 8, build. 3, TiNAO, +7(916)019-00-30, zarubean@gmail.com, https://orcid.org/0000-0002-2548-9506
Andrey I. Nichiporov, Laboratory Research Assistant, Moscow Multidisciplinary Clinical Center «Kommunarka», Moscow City Healthcare Department, 108814, Russia, Moscow, Sosenskoye village, Kommunarka village, Sosensky Stan str., 8, build. 3, TiNAO, andrei.ni4iporov@yandex.ru, https://orcid.org/0009-0006-6895-5278
Evgeniia A. Tiumeneva, Pathologist, Moscow Multidisciplinary Clinical Center «Kommunarka», Moscow City Healthcare Department, 108814, Russia, Moscow,
Sosenskoye village, Kommunarka village, Sosensky Stan str., 8, build. 3, TiNAO, +7(916)232-22-60, eugenie.tyumenev@yandex.ru, https://orcid.org/0009-0001-0338-7453
Igor A. Chernov, PhD, Associate Professor, Head of the Department of Pathological Anatomy and Forensic Medicine, Tyumen State Medical University, Ministry of Health of the Russia, 625023, Russia, Tyumen, Odesskaya str., 54, Chernov@tyumsmu.ru, https://orcid.org/0000-0002-6475-5731
Yuri A. Kirillov, Dr. Med. Sci., Professor, Pathologist, Moscow Multidisciplinary Clinical Center «Kommunarka», Moscow City Healthcare Department, 108814, Russia, Moscow, Sosenskoye village, Kommunarka village, Sosensky Stan str., 8, build. 3, TiNAO; Professor, Department of Pathological Anatomy and Forensic Medicine, Tyumen State Medical University, Ministry of Health of Russia, 625023, Russia, Tyumen, Odesskaya str., 54; Leading Researcher at the Clinical Morphology Laboratory, Research Institute of Human Morphology, 117418, Russia, Moscow, Tsyurupy str., 3, youri_kirillov@mail.ru, https://orcid.org/0000-0003-3555-0902
Corresponding author: Vladimir E. Rodionov, rodionov.ve@mail.ru
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