Malignant neoplasms and thromboses

Schulman S., Makatsaria N.A., Vorobyev A.V., Bitsadze V.O., Khizroeva D.Kh., Solopova A.G.

1) Research Institute of Thrombosis and Atherosclerosis, Faculty of Medicine, McMaster University, Hamilton, Ontario, Canada; 2) Obstetrics and Gynecology Department Two, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Objective. To carry out a systems analysis of data on the relationship between cancer and thrombotic events and to analyze risk factors for thrombosis in cancer patients.
Material and methods. The review includes data from foreign and Russian articles published on this topic in the past 10 years, which were found in e-Library and Pubmed.
Results. The paper presents data on the possibilities of using anticoagulant therapy in cancer patients. It analyzes the features of managing patients with recurrent thromboses: a change in the dosage of low molecular weight heparin or the need for implantation of a cava filter into the inferior vena cava.
Conclusion. Activated coagulation may increase the risk of cancer and, conversely, the effect of anticoagulants may reduce the risk of developing certain types of cancer.


malignant neoplasms
thrombotic events
hemostatic disorders
pathogenesis of thrombotic events
prevention of thromboses
anticoagulant therapy


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Received 30.03.2019

Accepted 19.04.2019

About the Authors

Sam Schulman, MD, PhD, Professor of the Thrombosis and Atherosclerosis Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada, professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University; E-mail:
Makatsariya Aleksander, MD, corresponding member of the Russian Academy of Sciences, Professor, Head of the Department of Obstetrics and Gynecology,
The First I.M. Sechenov Moscow State Medical University; E-mail:
Vorobev Alexander, PhD, Associate Professor of the Department of Obstetrics and Gynecology of the Faculty of Medical and Preventive, The First I.M. Sechenov Moscow State Medical University; E-mail:
Bitsadze Viktoria, MD, Professor of the Russian Academy of Sciences, Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University; E-mail:
Khizroeva Jamilya, MD, Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University; E-mail:
Solopova Antonina, MD, Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University;

For citations: Schulman S., Makatsaria N.A., Vorobyev A.V., Bitsadze V.O., Khizroeva D.Kh., Solopova A.G. Malignant neoplasms and thromboses. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (7): 14-23 (in Russian).

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