A possibility for health improvement in overweight and obese women at the stage of pregravid preparation
About half of women planning pregnancy have too much adipose tissue, insulin resistance, hypothalamic-pituitary-ovarian axis disorders, and consequently anovulation and infertility. Objective: To assess the results of using the biologically active dietary supplement Dikirogen (myo-inositol and D-chiroinositol in a ratio of 5:1) in conjunction with combination therapy for anovulation in overweight and obese women. Materials and methods: During 2021–2022, a descriptive study assessing the results of lifestyle changes (in diet and exercises) and nutritional support (a combination of myo-inositol 1000 mg and D-chiroinositol 200 mg, folic acid 200 μg, and manganese 5 mg (Dikirogen) was conducted in the clinics of Moscow, Nizhny Novgorod, Novosibirsk, Krasnodar, Yekaterinburg, and Voronezh in 197 reproductive-aged women who had overweight or obesity and anovulation for 2–4 months. Results: The use of the biologically active dietary supplement Dikirogen in conjunction with combination therapy (diet + exercises) caused decreases in body weight by 2.5 kg, body mass index (BMI) by 0.5 kg/m2, and waist circumference by 1.75 cm. The normal menstrual cycle was 1.41 times more often observed at Visit 2. There were reductions in LH levels from 8.45 (3.91) to 6.4 (4.9; 8.8) mU/ml and in the LH/FSH ratio from 1.4 (0.9; 2.0) to 1.2 (0.8; 1.6) (p<0.0001). There were also significant decreases in fasting glucose levels from 5.0 (4.5; 5.5) to 4.8 (4.2; 5.0) mmol/l (p<0.0001) and on the number of women with fasting glucose levels above 5.1 mmol/ml by 3.07 times. During 80–90 follow-up days, pregnancy occurred in 30 (15.2%) patients; at Visit 2, the ovulation test was positive in 96 (48.73%) women. Conclusion: The results of the study can recommend Dikirogen containing myo-inositol and D-chiroinositol in a ratio of 5:1, folic acid, and manganese in conjunction with combination therapy (diet, exercises) to obese and overweight women with complaints of anovulation and failure to achieve pregnancy, Authors' contributions: Radzinsky V.E. – concept and design of the study, approval of the final version of the article; Solovyeva A.V. – material collection and processing, text writing, editing; Kuleshov V.M., Katkova N.Yu., Mingaleva N.V., Korotkikh I.N., Oboskalova T.A., Vorontsova A.V. – material collection and processing. Conflicts of interest: The authors declare that there are no conflicts of interest. Funding: The investigation has not been sponsored. Patient Consent for Publication: The patients have signed an informed consent form to the publication of their data. Authors' Data Sharing Statement: The data supporting the conclusions of this investigation are available upon request from the corresponding author after approval by the principal investigator. For citation: Radzinsky V.E., Solovyeva A.V., Kuleshov V.M., Katkova N.Yu., Mingaleva N.V., Korotkikh I.N., Oboskalova T.A., Vorontsova A.V. A possibility for health improvement in overweight and obese women at the stage of pregravid preparation. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; 1: 83-90 (in Russian). https://dx.doi.org/10.18565/aig.2022.292Radzinsky V.E., Solovyeva A.V., Kuleshov V.M., Katkova N.Yu., Mingaleva N.V., Korotkikh I.N., Oboskalova T.A., Vorontsova A.V.
Keywords
pregravid preparation
obese and overweight women
anovulation
myo-inositol
D-chiroinositol
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Received 08.12.2022
Accepted 24.01.2023
About the Authors
Viktor Е. Radzinsky, Corresponding Member of the RAS, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology with the Course of Perinatology, Medical Institute of Peoples’ Friendship University of Russia (RUDN University), radzinsky@mail.ru, https://orcid.org/0000-0003-4956-0466,117198, Russia, Moscow, Miklukho-Maklaya str., 6.
Alina V. Solovyeva, Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology with the Course of Perinatology, Medical Institute of Peoples’ Friendship University of Russia (RUDN University), av_soloveva@mail.ru, https://orcid.org/0000-0001-6711-1563, 117198, Russia, Moscow, Miklukho-Maklaya str., 8.
Vitaliy M. Kuleshov, Dr. Med. Sci., Professor, Professor at the Obstetrics and Gynecology Department, Novosibirsk State Medical University, Ministry of Health of Russia, kuleshov_vm@mail.ru, 630091, Russia, Novosibirsk, Krasny prospect, 52.
Nadezhda Yu. Katkova, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Faculty of Additional Vocational Education, Privolzhsky Research Medical University, Ministry of Health of Russia, katkova_nu@inbox.ru, SPIN-код: 7967-5759, Author ID: 340045, 603005, Russia, Nizhny Novgorod,
Minin and Pozharsky sqr., 10/1.
Natalya V. Mingaleva, Dr. Med. Sci., Chief Freelance Specialist in Outpatient Obstetric and Gynecological Care of the Ministry of Health of the Krasnodar Territory; Professor, Department of Obstetrics, Gynecology and Perinatology, Kuban State Medical University, Ministry of Health of Russia, mingalevaN008@yandex.ru,
https://orcid.org/0000-0001-5440-3145, 350063, Russia, Krasnodar, M. Sedin str., 4.
Irina N. Korotkikh, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Faculty of Medicine, N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia, korotkikh_1950@mail.ru, 394066, Russia, Voronezh, Moskovsky Ave., 151.
Tatyana A. Oboskalova, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Ural State Medical University, Ministry of Health of Russia, oboskalova.tat@yandex.ru, https://orcid.org/0000-0003-0711-7896, SPIN: 9364-2321, 620219, Russia, Ekaterinburg, Repin str., 3.
Anna V. Vorontsova, PhD, Associate Professor, Department of Obstetrics and Gynecology, Ural State Medical University, Ministry of Health of Russia,
a_valerevna@mail.ru, https://orcid.org/0000-0002-0509-3328620219, 620219, Russia, Ekaterinburg, Repin str., 3.
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