Cardiovascular risk assessment tools for optimizing pregravid preparation: the results of the study on working women of reproductive age
Salov I.A., Malinova L.I., Tolstov S.N., Zhuk A.A., Denisova T.P.
Objective: To assess the possibilities of cardiovascular risk assessment tools for optimizing pregravid preparation of working women of reproductive age.
Materials and methods: A comprehensive analysis of employees at three commercial and manufacturing enterprises was conducted. The study included women with normal menstrual function planning pregnancy or who did not exclude the probability of getting pregnant within the next year. Age group classification adjusted for the study sample was used: Group 1 (peak fertility), Group 2 (reduced fertility), and Group 3 (perimenopause). The 10-year risk of fatal cardiovascular events (CVEs), total cardiovascular risk (TCR), and the parameters of cardiovascular health were assessed.
Results: The highest scores of total cardiovascular risk and the risk of fatal cardiovascular events were in perimenopause group – 1/20 (0/87; 2.01)% and 0.30 (0.22; 0.50)%, respectively, p=0.000. The highest cardiovascular health score was in the group of peak fertility – 575 (525; 600) (р=0.025, and had an inverse correlation with gestational hypertension in history (τ=-0.352; p=0.011), which, in turn, was distinguished by the highest population attributable risk of arterial hypertension (23.55%, p=0.002).
Conclusion: In the sample of working women of reproductive age, who were planning pregnancy or did not exclude the probability of getting pregnant, routine use of traditional cardiovascular risk assessment tools is not advisable. Integral assessment of cardiovascular health is associated with age-related fertility and can be used for risk stratification of hypertensive disorders at the stage of pregravid preparation.
Authors' contributions: Salov I.A., Malinova L.I., Tolstov S.N., Denisova T.P. – the concept and design of the study; Zhuk A.A., Malinova L.I. – material collection and processing; Malinova L.I., Denisova T.P. – statistical data processing, Malinova L.I., Tolstov S.N., Denisova T.P. – analysis and interpretation of the results. Malinova L.I., Zhuk A.A. – article writing; Salov I.A., Malinova L.I., Tolstov S.N., Denisova T.P. – article editing.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted in the frames of research initiative.
Ethical Approval: The study was approved by the local Ethics Committee of Saratov State Medical University named
after V.I. Razumovsky, Ministry of Health of Russia.
Patient Consent for Publication: The patients have signed informed consent for publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Salov I.A., Malinova L.I., Tolstov S.N., Zhuk A.A., Denisova T.P. Cardiovascular risk assessment tools for optimizing pregravid preparation: the results of the study on working women of reproductive age.
Akusherstvo i Gynecologia/Obstetrics and Gynecology. 2024; 11: 155-161 (in Russian)
https://dx.doi.org/10.18565/aig.2024.230
Keywords
cardio-obstetrics
pregravid preparation
risk assessment tools
arterial hypertension
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Received 13.09.2024
Accepted 28.10.2024
About the Authors
Igor A. Salov, Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia, https://orcid.org/0000-0002-1926-5418Lidia I. Malinova, Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia, lidia.malinova@yandex.ru, https://orcid.org/0000-0002-0951-9314
Sergey N. Tolstov, Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia, https://orcid.org/0000-0002-4546-9449
Alena A. Zhuk, Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia, https://orcid.org/0000-0002-5236-0871
Tatyana P. Denisova, Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia; https://orcid.org/0000-0003-4931-0969
Corresponding author: Lidia I. Malinova, lidia.malinova@yandex.ru
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