Impact of chemotherapy on the health of babies born to mothers with lymphomas and breast cancer
Aim. To investigate the health status of infants born to mothers with lymphomas and breast cancer undergoing chemotherapy (CT) during pregnancy. Materials and methods. The study comprised 223 newborn infants. Group 1A included 108 offspring of mothers who underwent CT. Group 1B consisted of 52 babies whose mothers did not receive CT. Group 2 comprised 63 babies born to healthy women. Results of follow-up were analyzed in 71 and 29 babies from groups 1A and 1B, respectively. Results. In groups 1A and 1B, 44.4% and 59.6% of infants, respectively, were born preterm (p = 0.051). The high percent of preterm infants was associated with maternal disease activity and the need to start/continue antitumor therapy after childbirth. The leading cause of infant morbidity was bronchopulmonary diseases, which was mainly associated with their prematurity. The rate of low birth weight deliveries (<10th percentile) did not significantly differ between the groups ((p = 0.20). The incidence of congenital malformations and minor developmental anomalies were comparable in the groups (p = 0.676 and p = 0.703) and did not differ from that in the general population. Conclusion. Prematurity is the primary cause of early neonatal morbidity in infants undergoing exposure to maternal CT. Prolonging pregnancy to full-term during CT reduces the incidence of preterm birth, which contributes to lowering infant mortality rates.Akhmedova A.I., Shmakov R.G., Polushkina E.S., Miroshina E.D., Makieva M.I., Zubkov V.V., Parokonnaya A.A., Sukhikh G.T.
Keywords
pregnancy
breast cancer
lymphomas
chemotherapy
antitumor therapy
newborn infants
prematurity
References
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Received 27.11.2019
Accepted 29.11.2019
About the Authors
Aminat I. Akhmedova, postgraduate student, FSBI National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov. E-mail: akhmedovag@yandex.ruAddress: 117997, Russia, Moscow, Oparina st., 4.
Roman G. Shmakov, MD, Ph.D, professor RAS, Director of the Institute of Obstetrics, FSBI National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov. E-mail: r_shmakov@oparina4.ru
Address: 117997, Russia, Moscow, Oparina st., 4.
Evgeniya S. Polushkina, Ph.D, senior researcher, FSBI National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov. E-mail: e_polushkina@oparina4.ru
Address: 117997, Russia, Moscow, Oparina st., 4.
Ekaterina D. Miroshina, postgraduate student, FSBI National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov. E-mail: lapshulchik@gmail.com
Address: 117997, Russia, Moscow, Oparina st., 4.
Mziya I. Makieva, neonatologist, head of the neonatal department FSBI National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov. E-mail: m_makieva@oparina4.ru
Address: 117997, Russia, Moscow, Oparina st., 4.
Viсtor V. Zubkov, MD, Ph.D, professor of the RAS, Director of the Institute of of neonatology and pediatrics, FSBI National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov. E-mail: v_zubkov@oparina4.ru
Address: 117997, Russia, Moscow, Oparina st., 4.
Anastasia A. Parоkonnaya, MD, Ph.D, Department of breast pathology FSBI National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov; senior researcher, department of Radiosurgery, FSBI N. N. Blokhin National Medical Research Centre of oncology of Ministry of Healthcare of Russian Federation, Moscow. E-mail: anapar1@yandex.ru
Address: 117997, Russia, Moscow, Oparina st., 4; 115478, Russia, Moscow, Kashirskoye shosse, d. 24.
Gennagy T. Sukhikh, MD, Ph.D, professor, academician of the RAS, director of FSBI National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov. V. I. Kulakov. E-mail: g_sukhikh@oparina4.ru
Address: 117997, Russia, Moscow, Oparina st., 4.
For citation: Akhmedova A.I., Shmakov R.G., Polushkina E.S., Miroshina E.D., Makieva M.I., Zubkov V.V., Parokonnaya A.A., Sukhikh G.T. Impact of chemotherapy on the health of babies born to mothers with lymphomas and breast cancer.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 3:155-63.(In Russian).
https://dx.doi.org/10.18565/aig.2020.3.155-163
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