Ectopic pregnancy associated with fallopian tube adenocarcinoma
Background. Fallopian tube cancer (FTC) is an extremely rare, difficult diagnostic malignant disease of the female reproductive system. The world literature describes single cases of FTC concurrent with tubal pregnancy.Levakov S.A., Sheshukova N.A., Bolshakova O.V., Tigieva A.V., Dobryakov A.V., Obukhova E.A.
Description. The paper describes a clinical case of diagnosed FTC after surgical treatment for tubal pregnancy. Patient P., aged 34 years, who had complained of vaginal bleeding and tensive pain in the right iliac region, was admitted to the Bakhrushins Brothers City Clinical Hospital. After complete clinical and laboratory examinations diagnosed right ectopic pregnancy, emergency surgical treatment was performed as laparoscopy and right-sided tubectomy. The postoperative period was uncomplicated; the patient was discharged home in satisfactory condition. Histological examination revealed the growth of well-differentiated fallopian tube adenocarcinoma and confirmed the diagnosis of ectopic pregnancy. The diagnosis was verified by immunohistochemical study
Conclusion. Preoperative diagnosis of FTC is extremely difficult; therefore the elaboration of a clear algorithm for the diagnosis and treatment of this condition is one of the important tasks in gynecologic oncology.
Keywords
fallopian tube adenocarcinoma
ectopic pregnancy
Supplementary Materials
- Fig. 1. Adenocarcinoma of the fallopian tube. HE staining, ×200
- Fig. 2. Adenocarcinoma of the fallopian tube. HE staining, ×400
- Fig. 3. Chorionic villi in the lumen of the fallopian tube, HE staining, ×200
- Fig. 4. Chorionic villi in the lumen of the fallopian tube, HE staining, ×200
- Fig. 5. Tubar adenocarcinoma with reaction to cytokeratin 7. Diffuse expression of cytokeratin 7. Immunostaining with anti-CK7 antibodies, ×200
- Fig. 6. Tubar adenocarcinoma with reaction to mucin 1. Diffuse expression of mucin 1, Immunostaining with anti-MUC1 antibodies, ×200
- Fig. 7. Tubar adenocarcinoma with reaction to PAX-8. Diffuse expression of PAX-8. Immunostaining with anti- PAX-8 antibodies, ×200
- Fig. 8. Tubar adenocarcinoma with reaction to WT-1. Diffuse expression of WT-1. Immunostaining with anti- WT-1 antibodies, ×200
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Received 06.06.2017
Accepted 23.06.2017
About the Authors
Sergey Levakov, MD, PhD, professor, head of the Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University.119991, Russia, Moscow, Trubetskaya str. 8, bld. 2
Natalya Sheshukova, MD, PhD, professor of the Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University.
119991, Russia, Moscow, Trubetskaya str. 8, bld. 2
Olesya Bolshakova, MD, PhD, associate professor of the Department of Obstetrics and Gynecology, Federal Research and Clinical Center
of Specialized Types of Medical Care and Medical Technologies, FMBA of Russia. 115682, Russia, Moscow, Orekhovy b-r 28
Anna Tigieva, MD, PhD, gynecologist of the Division of Gynecology, Bakhrushins Brothers City Clinical Hospital, Moscow Healthcare Department.
107014, Russia, Moscow, Stromynka str. 7
Andrey Dobryakov, MD, PhD, head of the Division of Pathology, Bakhrushins Brothers City Clinical Hospital, Moscow Healthcare Department.
107014, Russia, Moscow, Stromynka str. 7
Elizaveta Obukhova, resident of the Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University.
119991, Russia, Moscow, Trubetskaya str. 8, bld. 2
For citations: Levakov S.A., Sheshukova N.A., Bolshakova O.V., Tigieva A.V., Dobryakov A.V., Obukhova E.A. Ectopic pregnancy associated with fallopian tube adenocarcinoma. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (1): 142-7. (in Russian)
https://dx.doi.org/10.18565/aig.2018.1.142-147
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