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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2023№11
The effect of stress on...

The effect of stress on the female reproductive system: pathophysiology and neuroendocrine interactions

DOI
https://dx.doi.org/10.18565/aig.2023.175

Biryukova D.A., Amyan T.S., Gavisova A.A., Durinyan E.R., Gardanova Zh.R., Nikolaeva M.A., Krasnova N.A.

1) Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia; 2) Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Stress is an important factor that influences the work of many systems, and it can cause an imbalance in the human body. The issue of stress and its consequences is extremely important, since there is a rapid increase in behavior disorders caused by stress and stress-associated diseases all over the world (various forms of neuroses and depressions) which affect from 25 to 35% of the population. The impact of stress on the female reproductive system is of particular interest. Stress can be considered to be one of the most common and underestimated factors which contribute to the female infertility. The main aspect of scientific research is the study of the work and interaction of the nervous, immune and endocrine systems under the influence of external stimuli, namely stress factors. The analysis of the literature data indicates the adverse impact of stress factors on the outcomes of assisted reproductive technology programs, the processes of oogenesis and embryogenesis. Our literature review systematizes the data on the close relationship between the central nervous system, immune and endocrine systems; each of these systems contributes to the female reproductive health at various levels.
Conclusion: The optimal functioning of the female reproductive system under stress directly depends on the function of the central nervous system, endocrine and immune systems, as well as their direct interaction. It is necessary to search and develop new personalized approaches to the prevention and treatment of stress-related conditions. Further studies devoted to this problem can be beneficial not only for scientific researchers, but they can also have a high practical significance for clinicians.

Authors’ contributions: Biryukova D.A., Amyan T.S., Gavisova A.A., Durinyan E.R., Gardanova Zh.R., Nikolaeva M.A., Krasnova N.A. – review on the topic of publication, writing the article, final approval of the publication version.
Conflicts of interest: The authors declare no conflict of interest.
Funding: The study was conducted without sponsorship.
For citation: Biryukova D.A., Amyan T.S., Gavisova A.A., Durinyan E.R., Gardanova Zh.R., Nikolaeva M.A., Krasnova N.A. The effect of stress on the female reproductive system: pathophysiology and neuroendocrine interactions. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (11): 36-42 (in Russian)
https://dx.doi.org/10.18565/aig.2023.175

Keywords

stress
hypothalamic-pituitary-adrenal axis
hypothalamic-pituitary-ovarian axis
autonomic nervous system
immune system
endocrine system
reproductive function
infertility
assisted reproductive technologies
Full text (in Russian)

References

  1. Cannon W.B. Stresses and strains of homeostasis. Am. J. Med. Sci. 1935; 189(1): 13-4. https://dx.doi.org/10.1097/00000441-193501000-00001.
  2. Selye H. Stress and the general adaptation system. Br. Med J. 1950; 1(4667): 1383-92. https://dx.doi.org/10.1136/bmj.1.4667.1383.
  3. Turner A.L., Tillburg A.J. Stress, cortisol and reproduction in female pigs. Soc. Reprod. Fertil. Suppl. 2006; 62: 191-203.
  4. Einarsson S., Brandt Y., Lundeheim N., Madej A. Stress and its influence on reproduction in pigs: a review. Acta Vet. Scand. 2008; 50(1): 48. https://dx.doi.org/10.1186/1751-0147-50-48.
  5. Spiess J., Rivier J., Rivier C., Vale W. Primary structure of corticotropin- releasing factor from ovine hypothalamus. Proc. Natl. Acad. Sci. USA. 1981; 78(10): 6517-21. https://dx.doi.org/10.1073/pnas.78.10.6517.
  6. Won E., Kim Y. Stress, the autonomic nervous system, and the immune-kynurenine pathway in the etiology of depression. Curr. Neuropharmacol. 2016; 14(7): 665-73. https://doi.org/10.2174/1570159x14666151208113006.
  7. Weber B., Lewicka S., Deuschle M., Colla M., Heuser I. Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression. Psychoneuroendocrinology. 2000; 25(8):765-71. https://dx.doi.org/10.1016/s0306-4530(00)00023-8.
  8. Maharjan D.T., Syed A.A.S., Lin G.N., Ying W. Testosterone in female depression: a meta-analysis and Mendelian randomization study. Biomolecules. 2021; 11(3): 409. https://dx.doi.org/0.3390/biom11030409.
  9. Garg D., Berga S.L. Neuroendocrine mechanisms of reproduction. Handb. Clin. Neurol. 2020; 171: 3-23. https://dx.doi.org/10.1016/B978-0-444-64239-4.00001-1.
  10. Чернуха Г.Е., Бобров А.Е., Гусев Д.В., Табеева Г.И., Никитина Т.Е., Агамамедова И.Н. Психопатологические особенности и эндокринно-метаболический профиль пациенток с функциональной гипоталамической аменореей. Акушерство и гинекология. 2019; 2: 105-12. [Chernukha G.E., Bobrov A.E., Gusev D.V., Tabeeva G.I., Nikitina T.E., Agamamedova I.N. Psychopathological features and endocrine and metabolic profile in patients with functional hypothalamic amenorrhea. Obstetrics and Gynecology. 2019; (2): 105-12. (in Russian)]. https://dx.doi.org/10.18565/aig.2022.193.
  11. Чернуха Г.Е., Табеева Г.И., Гусев Д.В., Кузнецов С.Ю. Оценка показателей жировой ткани при функциональной гипоталамической аменорее. Акушерство и гинекология. 2018; 2: 74-80. [Chernukha G.E., Tabeeva G.I., Gusev D.V., Kuznetsov S.Yu. Estimation of adipose tissue indicators in functional hypothalamic amenorrhea. Obstetrics and Gynecology. 2018; (2): 74-80. (in Russian)]. https://dx.doi.org/10.18565/aig.2018.2.74-80.
  12. De Souza M.J., Nattiv A., Joy E., Mirsa M., Williams N.J., Mallinson R.J. et al. Female Athlete Triad Coalition consensus statement on treatment and return to play of the female athlete triad: 1st International Conference held in San Francisco, CA, May 2012, and 2nd International Conference held in Indianapolis, IN, May 2013. Clin. J. Sport. Med. 2014; 24(2): 96-119. https://dx.doi.org/10.1097/JSM.0000000000000085.
  13. Redman L.M., Loucks A.B. Menstrual disorders in athletes. Sports Med. 2005; 35(9): 747-55. https://dx.doi.org/10.2165/00007256-200535090-00002.
  14. Shufelt C.L., Torbati T., Dutra E. Hypothalamic Amenorrhea and the Long-Term Health Consequences. Semin. Reprod. Med. 2017; 35(3): 256-62. https://dx.doi.org/10.1055/s-0037-1603581.
  15. Чернуха Г.Е., Гусев Д.В., Табеева Г.И., Прилуцкая В.Ю. Современные принципы терапии функциональной гипоталамической аменореи. Акушерство и гинекология. 2018; 6: 11-7. [Chernukha G.E., Gusev D.V., Tabeeva G.I., Prilutskaya I.Y. Current principles of therapy for functional hypothalamic amenorrhea. Obstetrics and Gynecology. 2018; (6): 11-7 (in Russian)]. https://dx.doi.org/10.18565/aig.2018.6.11-17.
  16. Sadigh A.R., Mihanfar A., Fattahi A., Latifi Z., Akbazadeh M., Hajipour H. et al. S100 protein family and embryo implantation. J. Cell. Biochem. 2019; 120(12): 19229-44. https://dx.doi.org/10.1002/jcb.29261.
  17. Suter D.E., Schwartz N.B. Effects of glucocorticoids on secretion of luteinizing hormone and follicle-stimulating hormone by female rat pituitary cells in vitro. Endocrinology. 1985; 117(3): 849-54. https://dx.doi.org/10.1210/endo-117-3-849.
  18. Fateh M., Ben‐Rafeal Z., Benadiva C.A., Mastroianni L., Flickinger G.L. Cortisol level in human follicular fluid. Fertil. Steril. 1989; 51: 538–41. https://dx.doi.org/10.1016/s0015-0282(16)60572-1.
  19. Barroso G., Oehninger S., Monzó A., Kolm P., Gibbons W.E., Muasher S.J. High FSH:LH ratio and low LH levels in basal cycle day 3: impact on follicular development and IVF outcome. J. Assist. Reprod. Genet. 2001; 18(9): 499–505. https://dx.doi.org/10.1023/a:1016601110424.
  20. Santa-Cruz D.C., Agudo D. Impact of underlying stress in infertility. Curr. Opin. Obstet. Gynecol. 2020; 32(3): 233-6. https://dx.doi.org/10.1097/gco.0000000000000628.
  21. Nik Hazlina N.H., Norhayati M.N., Shaiful Bahari I., Nik Muhammad Arif N.A. Worldwide prevalence, risk factors and psychological impact of infertility among women: a systematic review and meta-analysis. BMJ Open. 2022; 12(3): e057132. https://dx.doi.org/10.1136/bmjopen-2021-057132.
  22. Simionescu G., Doroftei B., Maftei R., Obreja B.E., Anton E., Grab D. et al. The complex relationship between infertility and psychological distress (Review). Exp. Ther. Med. 2021; 21(4): 306. https://dx.doi.org/10.3892/etm.2021.9737.
  23. Всемирная организация здравоохранения. Бесплодие. https://www.who.int/news-room/fact-sheets/detail/infertility. [WHO. Infertility. https://www.who.int/news-room/fact-sheets/detail/infertility].
  24. Wang X., Wang Y. The Effectiveness of Mindfulness-Based Intervention on Emotional States of Women Undergoing Fertility Treatment: A Meta-Analysis. J. Sex Marital Therapy. 2023; 49(3): 249-58. https://dx.doi.org/10.1080/0092623x.2022.2109542.
  25. Sharma A., Shrivastava D. Psychological problems related to infertility (Review). Cureus. 2022; 14(10): e30320. https://dx.doi.org/10.7759/cureus.30320.
  26. Гохберг Я.А., Макарова Н.П., Бабаян А.А., Калинина Е.А. Роль различных факторов воздействия на эндометрий в повышении эффективности программ вспомогательных репродуктивных технологий. Акушерство и гинекология. 2021; 1: 28-34. [Gokhberg Ya.A., Makarova N.P., Babayan A.A., Kalinina E.A. The role of various factors affecting the endometrium in enhancing the effectiveness of assisted reproductive technology programs. Obstetrics and Gynecology. 2021; (1): 28-34 (in Russian)]. https://dx.doi.org/10.18565/aig.2021.1.28-34.
  27. Киракосян Е.В., Назаренко Т.А., Павлович С.В. Поиск причин формирования нарушений репродуктивной системы: обзор научных исследований. 2021; 11: 18-25. [Kirakosyan E.V., Nazarenko T.A., Pavlovich S.V. Search for the causes of reproductive system disorders: a research review. Obstetrics and Gynecology. 2021; (11): 18-25 (in Russian)]. https://dx.doi.org/10.18565/aig.2021.11.18-25.
  28. Ebbesen S.M.S., Zachariae R., Mehlsen M.Y., Thomsen D., Hojgaard A., Ottosen L. et al. Stressful life events are associated with a poor in-vitro fertilization (IVF) outcome: a prospective study. Hum. Reprod. 2009; 24(9): 2173-82. https://dx.doi.org/10.1093/humrep/dep185.
  29. Meldrum D.R. Introduction: examining the many potential reasons why euploid blastocysts do not always result in viable pregnancies: part 1. Fertil. Steril. 2016; 105(3): 545-7. https://dx.doi.org/10.1016/j.fertnstert.2015.12.007.
  30. Николаева М.А., Бабаян А.А., Арефьева А.С., Чаговец В.В., Стародубцева Н.Л, Франкевич В.Е., Калинина Е.А., Кречетова Л.В., Сухих Г.Т. Влияют ли половые контакты в цикле ЭКО/ИКСИ на толщину эндометрия при наличии иммуногормональных маркеров стресса в семенной плазме? 2022; 10: 103-14. [Nikolaeva M.A., Babayan A.A., Arefieva A.S., Chagovets V.V., Starodubtseva N.L, Frankevich V.E., Kalinina E.A., Krechetova L.V., Sukhikh G.T. Does sexual intercourse during IVF/ICSI cycle affect endometrial thickness in the presence of immunohormonal markers of stress in the seminal plasma? Obstetrics and Gynecology. 2022; (10): 103-14 (in Russian)]. https://dx.doi.org/10.18565/aig.2022.10.103-114.
  31. Massey A.J., Campbell B., Raine-Fenning N., Aujla N., Vedhara K. The association of physiological cortisol and IVF treatment outcomes: a systematic review. Reprod. Med. Biol. 2014; 13(4): 161-76. https://dx.doi.org/10.1007/s12522-014-0179-z.
  32. Keay S.D., Harlow C.R., Wood P.J., Jenkins J.M., Cahill D.J. Higher cortisol: cortisone ratios in the preovulatory follicle of completely unstimulated IVF cycles indicate oocytes with increased pregnancy potential. Hum. Reprod. 2002; 9: 2410-4. https://dx.doi.org/10.1093/humrep/17.9.2410.
  33. Stalder T., Steudte-Schmiedgen S., Alexander N., Klucken T., Vater A., Wichmann S. et al. Stress-related and basic determinants of hair cortisol in humans: a meta-analysis. Psychoneuroendocrinology. 2017; 77: 261-74. https://dx.doi.org/10.1016/j.psyneuen.2016.12.017.
  34. Massey A.J., Campbell B.K., Raine-Fenning N., Pincott-Allen C., Perry J., Vedhara K. Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF. Psychoneuroendocrinology. 2016; 74: 397-405. https://dx.doi.org/10.1016/j.psyneuen.2016.08.027.

Received 20.07.2023

Accepted 17.10.2023

About the Authors

Daria A. Biryukova, medical resident, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of
the Russian Federation, +7(968) 511-20-02, dasha4465@yandex.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.
Tatiana S. Amyan, Ph.D., Researcher at the 1st Gynecology Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and
Perinatology, Ministry of Health of the Russian Federation, +7(926)163-28-33, t_amyan@oparina4.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.
Alla A. Gavisova, Ph.D., Leading Researcher at the 1st Gynecology Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, +7(916)829-05-90, gavialla@yandex.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.
Evelina R. Durinyan, Ph.D., Senior Researcher at the 1st Gynecology Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, +7(916)612-99-30, evelina_durinyan@mail.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.
Zhanna R. Gardanova, Dr. Med. Sci., Professor, Head of the Psychiatric Department ICPSW, Pirogov Russian National Research Medical University, Ministry of Health of
the Russian Federation, +7(965)277-35-09, zanna7777@inbox.ru, 117997, Russia, Moscow, Ostrovityanova str., 1.
Marina A. Nikolayeva, Ph.D., Leading Researcher at the Laboratory of Clinical Immunology, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, +7(495)438-11-83, MNikolaeva@oparina4.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.
Natalya A. Krasnova, Ph.D., employee of the 1st Gynecology Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, +7(915)355-42-03, n_krasnova@oparina4.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.

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