Psychoemotional state of women undergoing in vitro fertilization treatment
Yasnaya D.V., Likhacheva V.V., Proskuryakova L.A., Alontseva V.V., Azarova O.V.
Background: A combination of factors causing infertility and consisting of somatic, mental and social determinants of health, requires a comprehensive study of strategies to improve the effectiveness of assisted reproductive technologies (ART). At the same time, exploration of the psychoemotional state of patients undergoing ART treatment, requires both psychophysiological and psychodiagnostic research methods to obtain more objective data.
Objective: To explore specific characteristics of the psychoemotional state of women undergoing in vitro fertilization (IVF) treatment.
Materials and methods: The psycho-emotional state of women was assessed using psychophysiological methods (electroencephalography (EEG) analysis), psychodiagnostic methods: Psychological Stress Measure (PSM-25) (R. Tessier, L. Lemyre, L. Fillion, adapted by N.E. Vodopyanova) and Anxiety and Depression Questionnaire – a shortened version of the Clinical Questionnaire for Identification and Assessment of Neurotic States (K.K. Yakhin, D.M. Mendelevich), as well as statistical methods.
Results: Data analysis found statistically significant differences in the properties of EEG alpha rhythm frequency, as well as in manifestation of irritative changes — diffuse asynchronous beta activity in the group of women undergoing repeated IVF cycles. Nonconforming data were also found between objective (EEG) and subjective (psychodiagnostic methods) assessment of the psychoemotional state of women undergoing repeated IVF treatment. Objective assessment showed that regardless of the number of IVF attempts, the signs of stress were present in women in both groups and became more intense with repeated IFV failures. According to subjective assessment, women in both groups did not report experiencing stress, anxiety, or depression, even after failed IVF attempts.
Conclusion: The obtained data indicate the necessity to use objective methods, such as EEG analysis for assessment of the psychoemotional state in women undergoing IVF treatment for infertility. This approach will allow timely correction of the identified impairments, improved adherence of infertile patients to continue treatment, and will improve the effectiveness of ART programs.
Authors' contributions: Yasnaya D.V., Likhacheva V.V., Proskuryakova L.A., Alontseva V.V., Azarova O.V. – the concept and design of the study, obtaining data for analysis, literature review, material processing and analysis on the topic of the article, manuscript writing and editing.
Conflicts of interest: The authors confirm that they have no conflict of interest to declare.
Funding: The study was carried out without any sponsorship.
Acknowledgment: The authors express their deep gratitude to I.D. Martynov, Ph.D., for EEG interpretation.
Ethical Approval: The study was approved by the local Ethics Committee of Novokuznetsk State Institute of Postgraduate Medical Education – a branch of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia/Kuzbass Humanitarian and Pedagogical Institute of Kemerovo State University
Patient Consent for Publication: The patients have signed informed consent for publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Yasnaya D.V., Likhacheva V.V., Proskuryakova L.A., Alontseva V.V., Azarova O.V.
Psychoemotional state of women undergoing in vitro fertilization treatment.
Akusherstvo i Gynekologiya/Obstetrics and Gynecology. 2025; (3): 136-143 (in Russian)
https://dx.doi.org/10.18565/aig.2024.310
Keywords
infertility
in vitro fertilization (IVF)
electroencephalography
stress
anxiety
depression
IVF failure
beta rhythm
References
- Adamsom G.D., de Mouzon J., Chambers G.M., Zegers-Hochschild F. International Committee for Monitoring Assisted Reproductive Technology: world report on assisted reproductive technology, 2011. Fertil. Steril. 2018; 110(6): 1067-80. https://dx.doi.org/10.1016/j.fertnstert.2018.06.039.
- Бирюкова А.М., Мартиросян Я.О., Ковальчик А.И., Хубаева Д.Г. Диагностика и лечение бесплодия. Клиническая лекция. Медицинский оппонент. 2021; 2(14): 41-5. [Birukova A.M., Martirosyan Ya.O., Kovalchuk A.I., Khubaeva D.G. Infertility diagnosis and treatment. Clinical lecture. Medical Opponent. 2021; 2(14): 41-5. (in Russian)].
- Паскарь С.С., Калугина А.С., Ткачук А.Г. Оценка удовлетворенности качеством лечения пациенток с бесплодием с помощью вспомогательных репродуктивных технологий. Российский вестник акушера-гинеколога. 2019; 19(5): 77-82. [Paskar S.S., Kalugina A.S., Tkachuk A.G. Evaluating patient satisfaction regarding assisted reproductive technologies. Russian Bulletin of Obstetrician-Gynecologist. 2019; 19(5): 77 82. (in Russian)]. https://dx.doi.org/10.17116/rosakush20191905177.
- Purewal S., Chapman S.C.E., van den Akker O.B.A. A systematic review and meta‐analysis of psychological predictors of successful assisted reproductive technologies. BMC Res. Notes. 2017; 10(1): 711. https://dx.doi.org/10.1186/s13104-017- 3049-z.
- Purewal S., Chapman S.C.E, van den Akker O.B.A. Depression, anxiety and lifestyle factors and outcomes from IVF. Reproductive Biomed. Online. 2018; 36(6): 646-57. https://dx.doi.org/10.1016/j.rbmo.2018.03.010.
- Maroufizadeh S., Navid B., Omani-Samani R., Amini P. The effects of depression, anxiety and stress symptoms on the clinical pregnancy rate in women undergoing IVF treatment. BMC Res. Notes. 2019; 12(1): 256. https://dx.doi.org/10.1186/s13104-019-4294-0.
- Филиппова Г.Г. Психологические аспекты вспомогательных репродуктивных технологий: обзор зарубежных и Российских исследований. Современная зарубежная психология. 2022; 11(1): 26-38. [Filippova G.G. Psychological aspects of assisted reproductive technologies: a review of foreign and Russian studies. Modern Foreign Psychology. 2022; 11(1): 26-38. (in Russian)]. https://dx.doi.org/10.17759/jmfp.2022110103.
- Tuncay G., Yıldız S., Karaer A., Reyhani I., Özgöcer T., Ucar C. et al. Stress in couples undergoing assisted reproductive technology. Arch. Gynecol. Obstet. 2020; 301(6):1561-7. https://dx.doi.org/10.1007/s00404-020-05549-8.
- Rooney K., Domar A. The relationship between stress and infertility. Dialogues Clin. Neurosci. 2018; 20(1): 41-7. https://dx.doi.org/10.31887/DCNS.2018.20.1/klrooney.
- Гаврилова Е.А. Стресс и патология сердца. М.: ГЭОТАР-Медиа; 2024. 237 с. [Gavrilova E.A. Stress and heart pathology. Moscow: GEOTAR-Media; 2024. 237 p. (in Russian)].
- Vanhollebeke G., De Smet S., De Raedt R., Baeken C., van Mierlo P., Vanderhasselt M.A. The neural correlates of psychosocial stress: A systematic review and meta-analysis of spectral analysis EEG studies. Neurobiol. Stress. 2022; 18: 100452. https://dx.doi.org/10.1016/j.ynstr.2022.100452.
- Ясная Д.В., Проскурякова Л.А., Мартынов И.Д., Лихачева В.В. Электроэнцефалографические показатели переживания стресса у женщин, проходящих подготовку к процедуре экстракорпорального оплодотворения. Современные вопросы биомедицины. 2024; 8(3): 18. [Yasnaya D.V., Proskuryakova L.A., Martynov I.D., Likhachyova V.V. Electroencephalographic indicators of stress of women in preparation for in vitro fertilization procedure. Modern Issues of Biomedicine. 2024; 8(3): 18. (in Russian)]. https://dx.doi.org/10.24412/2588-0500-2024_08_03_18.
- Приказ Минздрава РФ от 31.07.2020 № 803Н «О порядке использования вспомогательных репродуктивных технологий, противопоказаниях и ограничениях к их применению». Доступно по: https://normativ.kontur.ru/document?moduleId=1&documentId=373901 [Order of the Ministry of Health of the Russian Federation No. 803N dated 07/31/2020 «On the procedure for using assisted reproductive technologies, contraindications and restrictions on their use. Available at: https://normativ.kontur.ru/document?moduleId=1&documentId=373901 (in Russian)].
- Мартынов И.Д., Ямщикова А.В., Флейшман А.Н., Петровский С.А. Эффективность транскраниальной магнитной стимуляции в лечении профессиональной полинейропатии. Гигиена и санитария. 2023; 102(4): 351-5. [Martynov I.D., Yamshchikova A.V., Fleishman A.N., Petrovskiy S.A. Efficiency of the transcranial magnetic stimulation in the treatment of occupational polyneuropathy. Hygiene and Sanitation. 2023; 102(4): 351-5. (in Russian)]. https://dx.doi.org/10.47470/0016-9900-2023-102-4-351-355.
- Александров М.В., ред. Электроэнцефалография: руководство. 3-е изд. Санкт-Петербург: СпецЛит; 2019. 200 с. [Alexandrov M.V., ed. Electroencephalography: a guide. 3 ed. St. Petersburg: SpetsLit; 2019. 200 p. (in Russian)].
- Simionescu G., Doroftei B., Maftei R., Obreja B.E., Anton E., Grab D. et al. The complex relationship between infertility and psychological distress (review). Exp. Ther. Med. 2021; 21(4): 306. https://dx.doi.org/10.3892/etm.2021.9737.
- Воронина И.Д., Бохан Т.Г., Терехина О.В., Малых С.Б., Ковас Ю.В. Демографические показатели, образ жизни и здоровье в семьях с естественной и индуцированной беременностью в России и Великобритании. Теоретическая и экспериментальная психология. 2017; 9(4): 63-76. [Voronina I.D., Bohan T.G., Terekhina O.V., Malykh S.B., Kovas Yu.V. Demographic indicators, lifestyle, and health in families with natural and induced pregnancies in Russia and Great Britain. Theoretical and Experimental Psychology. 2017; 9(4): 63-76. (in Russian)].
- Гончаров Г.В., Ильина О.В., Труфанова Н.Г., Воликова Г.А. Ритмическая организация ЭЭГ-коррелятов устойчивости к эмоциональному стрессу у женщин фертильного возраста. Вестник Волгоградского государственного медицинского университета. 2010; 7(4): 79-82. [Goncharov G.V., Il'ina O.V., Trufanova N.G., Volikova G.A. Rhythmic organization of EEG-correlates of stability to emotional stress at reproductive age in women. Journal of Volgograd State Medical University. 2010; 7(4): 79-82. (in Russian)].
- Rockliff H., Lightman S., Rhidian E., Buchanan H., Gordon U., Vedhara K. A systematic review of psychosocial factors associated with emotional adjustment in in vitro fertilization patients. Hum. Reprod. Update. 2014; 20(4): 594-613. https://dx.doi.org/10.1093/humupd/dmu010.
Received 05.12.2024
Accepted 13.03.2025
About the Authors
Darya V. Yasnaya, Senior Lecturer at the Department of Psychology and General Pedagogy, Kuzbass Humanitarian and Pedagogical Institute, Kemerovo State University, 654041, Russia, Kemerovo Oblast – Kuzbass, Novokuznetsk, Tsiolkovsky str., 23, st1daria@ya.ru, https://orcid.org/0009-0004-0659-7183Viktoria V. Likhacheva, Dr. Med. Sci., Professor, Department of Obstetrics and Gynecology, Novokuznetsk State Institute for Further Training of Physicians – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia, 654005, Russia, Kemerovo Oblast – Kuzbass, Novokuznetsk,
Stroiteley Ave., 5, Higher Category Obstetrician-Gynecologist, viroli@mail.ru, https://orcid.org/0000-0002-5637-7590
Larisa A. Proskuryakova, Dr. Bio. Sci., Professor, Department of Psychology and General Pedagogy, Kuzbass Humanitarian and Pedagogical Institute, Kemerovo State University, 654041, Russia, Kemerovo Oblast – Kuzbass, Novokuznetsk, Tsiolkovsky str., 23; Associate Professor, Department of Hygiene, Epidemiology and Healthy Living, Novokuznetsk State Institute for Further Training of Physicians – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia, 654005, Russia, Kemerovo Oblast – Kuzbass, Novokuznetsk, Stroiteley Ave., 5, lora-al@yandex.ru, Researcher ID: AAE-5730-2022, SPIN: 5636-0613,
Scopus Author ID: 57200689936, https://orcid.org/0000-0002-9583-9161
Valeriya V. Alontseva, 6th year student, Medical Faculty, Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia, 197022, Russia, Saint Petersburg, Leo Tolstoy str., 6-8, leral2612@mail.ru
Olga V. Azarova, Obstetrician-Gynecologist, Reproductive Specialist, Head of the ART Department, Expert LLC, 654041, Russia, Kemerovo Oblast – Kuzbass, Novokuznetsk, Kutuzov str., 17a, az.o@mail.ru, https://orcid.org/0000-0002-2954-7494
Corresponding author: Larisa A. Proskuryakova, lora-al@yandex.ru
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