Impact of sperm DNA fragmentation on the outcomes of pregnancies following natural conception and assisted reproductive techniques
Berdnikova A.I., Ushakova I.V., Gavisova A.A., Ibragimova M.Kh., Durinyan E.R.
The male factor can be responsible for the inability of couples to conceive a child in 50% of the cases. The standard semen analysis does not completely reflect impaired integrity of spermatozoa genetic material, which may be associated with difficulties in achieving natural conception or with poorer outcomes of IVF programs. Therefore, sperm DNA fragmentation is increasingly used by clinicians to assess male infertility, especially in couples with repeated reproductive losses.
This review presents the analysis of the results reported in the literature on the effect of sperm DNA fragmentation on the outcomes of ART programs; the relationship between DNA fragmentation parameters and early reproductive losses in couples with male factor infertility was determined. A high level of sperm DNA fragmentation has been shown to have a negative effect on the fertilizing ability of spermatozoa. Sperm DNA damage may provide a reliable biomarker of sporadic and habitual miscarriage after natural or assisted conception, as well as provide new guidelines for future approaches to fertility restoration.
Conclusion: Impaired integrity of ejaculate DNA structure has a significant impact on both the natural conception and outcomes of ART programs. In order to achieve effective outcomes of IVF cycles and reduce the risk of early reproductive losses, it is necessary to introduce sperm DNA fragmentation testing into routine practice for specific groups of couples.
Authors’ contributions: All authors equally participated in preparing the publication: Berdnikova A.I. – developing the concept and design of the study, collecting literary data, writing the article; Gavisova A.A., Ushakova I.V., Popova A.Yu. – developing the concept and design of the study, editing the article; Ibragimova M.Kh., Durinyan E.R. – editing the article.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The study was carried out without sponsorship.
For citation: Berdnikova A.I., Ushakova I.V., Gavisova A.A., Popova A.Yu., Ibragimova M.Kh., Durinyan E.R.
Impact of sperm DNA fragmentation on the outcomes of pregnancies following natural conception and
assisted reproductive techniques.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (12): 12-18 (in Russian)
https://dx.doi.org/10.18565/aig.2024.191
Keywords
male factor infertility
semen analysis
TUNEL
DNA fragmentation
reproductive function
early reproductive losses
assisted reproductive techniques
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Received 02.08.2024
Accepted 18.11.2024
About the Authors
Anastasia I. Berdnikova, PhD student, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology,Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4, berdnikova8002@mail.ru
Irina V. Ushakova, PhD, Researcher at the 1st Gynecological Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4, irisun77@mail.ru
Alla A. Gavisova, Dr. Med. Sci., Head of the 1st Gynecological Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4, gavialla@yandex.ru
Alina Yu. Popova, PhD, Senior Researcher at the Department of Andrology and Urology, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4, alina-dock@ya.ru
Muminat Kh. Ibragimova, PhD, obstetrician-gynecologist-reproduktologist at the 1st Gynecological Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4, m_ibragimova@oparina4.ru
Evelina R. Durinyan, PhD, obstetrician-gynecologist-reproduktologist at the 1st Gynecological Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4, e_durinyan@oparina4.ru
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